Cardiovascular actions of neuropeptide Y and social stress.

abstract：:Thyroglobulin (Tg) is cleaved into several peptides during thyroid hormone synthesis, an oxidative process. P40, an iodinated C-terminal peptide from human Tg, has a molecular weight of about 40 kDa and contains two hormonogenic sites. P40 is the smallest peptide that is still recognized by monoclonal antibodies from ...

journal_title：Peptides

authors： El Hassani RA,Estienne V,Blanchin S,Durand-Gorde JM,Mallet B,De Micco C,Carayon P,Lalaoui K,Ruf J

更新日期：2004-06-01 00:00:00

abstract：:The effects of iontophoretically applied human pancreatic growth hormone-releasing factor (hpGRF), peptide histidine isoleucine (PHI-27), and somatostatin (SS) on the extracellular activity of single cells in the hypothalamus, thalamus, and cortex of the rat brain were studied in urethane-anesthetized, male rats. Neur...

journal_title：Peptides

authors： Twery MJ,Moss RL

更新日期：1985-07-01 00:00:00

abstract：:We tested the effects of intra-lateral septal infusions of neuropeptide Y (NPY) combined with systemic injections of topiramate in the DRL-72s paradigm and the elevated plus-maze test in male Wistar rats. Intra-lateral septal infusions of desipramine (5.0 microg/microl; P<0.05) or intra-lateral septal infusions of NPY...

journal_title：Peptides

authors： Molina-Hernández M,Téllez-Alcántara NP,Olivera-Lopez JI,Jaramillo MT

更新日期：2010-06-01 00:00:00

abstract：:The elevated T-maze was combined with a free exploration protocol, which, in contrast to the conventional procedure, dispenses with handling of the animals during the experimental sessions. This allows measurement of fear indexes derived from the elevated plus-maze as well as assessment of acquisition of open arm avoi...

journal_title：Peptides

authors： Echeverry MB,Hasenöhrl RU,Huston JP,Tomaz C

更新日期：2001-07-01 00:00:00

abstract：:Immunohistochemical studies were conducted on sections of cat hypothalamus in order to determine the distribution of neurons containing alpha-melanocyte stimulating hormone and beta-endorphin immunoreactivity. A large number of neurons in the arcuate nucleus were stained after incubation of sections with antisera to e...

journal_title：Peptides

authors： Micevych PE,Elde RP

更新日期：1982-07-01 00:00:00

abstract：:The localization of endozepine-like immunoreactivity in the brain of the frog Rana ridibunda was investigated by indirect immunofluorescence, using an antiserum against synthetic rat octadecaneuropeptide (ODN). A specific immunoreaction was detected in ependymal cells lining the ventricular system of the brain and in ...

journal_title：Peptides

authors： Malagon M,Vaudry H,Vallarino M,Gracia-Navarro F,Tonon MC

更新日期：1992-01-01 00:00:00

abstract：:A 41 amino acid peptide, probably identical in structure to human corticotropin releasing factor, was isolated from 70 equine hypothalami by methanol extraction, immunoaffinity chromatography and single step of reverse phase HPLC. The amino acid sequence was determined by gas phase sequence analysis. Probable carboxyl...

journal_title：Peptides

authors： Livesey JH,Carne A,Irvine CH,Ellis J,Evans MJ,Smith R,Donald RA

更新日期：1991-11-01 00:00:00

abstract：:Early-life stress is a key predisposing factor to the development of functional gastrointestinal (GI) disorders. Thus, changes in stress-related molecular substrates which influence colonic function may be important in understanding the pathophysiology of such disorders. Activation of peripheral corticotropin-releasin...

journal_title：Peptides

authors： O'Malley D,Dinan TG,Cryan JF

更新日期：2010-04-01 00:00:00

abstract：:Trefoil factors (TFFs) 1, 2 and 3 are small polypeptides that are co-secreted with mucin throughout the body. They are up-regulated in cancer and inflammatory processes in the gastrointestinal system, where they are proposed to be involved in tissue regeneration, proliferation and protection. Our aim was to explore th...

journal_title：Peptides

authors： Viby NE,Nexø E,Kissow H,Andreassen H,Clementsen P,Thim L,Poulsen SS

更新日期：2015-01-01 00:00:00

abstract：:The aims of these studies were to determine the precise molecular nature of immunoreactive (IR-) vasopressin (AVP) in the ovine hypothalamo-pituitary axis and to examine a possible role for glucocorticoids in regulating both AVP processing and levels in this axis. The IR-AVP in extracts of paraventricular nucleus, med...

journal_title：Peptides

authors： Shen PJ,Clarke IJ,Funder JW,Smith AI

更新日期：1993-07-01 00:00:00

abstract：:In the present study we used intracerebral microdialysis techniques to examine whether angiotensin II (ANG II) modulates the release of serotonin (5-hydroxytryptamine, 5-HT) in the subfornical organ (SFO) in freely moving rats. Extracellular concentrations of 5-HT and its metabolite 5-hydroxyindoleacetic acid (5-HIAA)...

journal_title：Peptides

authors： Tanaka J,Kariya K,Nomura M

更新日期：2003-06-01 00:00:00

abstract：:CRF injected into the third cerebral ventricle (0.5-2.5 micrograms) caused dose-related reductions in fever induced in rabbits by IV administration of leukocytic pyrogen. Control injections of CRF when the same animals were afebrile did not alter normal body temperature. Intravenous injections of 5 and 20 micrograms C...

journal_title：Peptides

authors： Bernardini GL,Richards DB,Lipton JM

更新日期：1984-01-01 00:00:00

abstract：:Urinary tract infections (UTI) are important health problems and predisposing causes of UTI are not entirely known. Neuro-immune interactions play an important role in human health and disease. Capsaicin-sensitive sensory nerves which in nerve bladder extensively regulate immune system through neuropeptides such as su...

journal_title：Peptides

authors： Altuntaş SÇ,Ipekçi T,Yakupoğlu G,Erin N

更新日期：2014-06-01 00:00:00

abstract：:The aim was to study the effects of C-type natriuretic peptide (CNP) on mean arterial pressure (MAP) and the cardiovascular nitric oxide (NO) system in spontaneously hypertensive rats (SHR), and to investigate the signaling pathways involved in this interaction. SHR and WKY rats were infused with saline or CNP. MAP an...

journal_title：Peptides

authors： Caniffi C,Elesgaray R,Gironacci M,Arranz C,Costa MA

更新日期：2010-07-01 00:00:00

abstract：:We have studied the in vitro effect of VIP and histamine on ultrastructure of the parietal cells in isolated guinea pig fundic glands. The morphological changes induced by histamine in the parietal cells can be compared to those observed after histamine stimulation in vivo or in vitro on gastric mucosa preparations. I...

journal_title：Peptides

authors： Anteunis A,Gespach C,Astesano A,Emami S,Robineaux R,Rosselin G

更新日期：1984-03-01 00:00:00

abstract：:Although enterostatin (VPDPR) inhibited morphine-induced analgesia, it had no affinity for mu-opioid receptors. VPDPR administration was reported to elevate serum corticosterone levels. We found that corticosterone exhibited a similar anti-analgesic effect selective for mu-opioid. Furthermore, the anti-analgesic effec...

journal_title：Peptides

authors： Takenaka Y,Nakamura F,Usui H,Lipkowski AW,Toth G,Yoshikawa M

更新日期：2003-05-01 00:00:00

abstract：:A series of Locusta adipokinetic hormone I (AKH-I), < QLNFTPNWGTa, analogues, were synthesized with modifications at the C-terminal threonine residue using a combination of solid- and liquid-phase methodology and evaluated in Locusta migratoria, in a lipid mobilization assay in vivo and an acetate uptake assay in vitr...

journal_title：Peptides

authors： Lee MJ,Goldsworthy GJ,Poulos CP,Velentza A

更新日期：1996-01-01 00:00:00

abstract：:Solubilization of rat synaptic membranes by Triton X-100 followed by DEAE-cellulose chromatography allowed the separation of a phosphoramidon-sensitive endopeptidase that cleaved CCK-8. This enzymatic activity revealed similar if not identical to "enkephalinase A." A major cleavage point, at the Trp30-Met31 bond, and ...

journal_title：Peptides

authors： Deschodt-Lanckman M,Koulischer D,Przedborski S,Lauwereys M

更新日期：1984-05-01 00:00:00

abstract：:We have developed a semi-intact preparation-consisting of an isolated oviduct with abdominal ganglia VII and VIII intact and attached-with which to characterize the effects on oviduct contraction, of peptides that are bath applied to CNS tissues. The work presented here offers a qualitative analysis of the central eff...

journal_title：Peptides

authors： Kwok R,Orchard I

更新日期：2002-11-01 00:00:00

abstract：:This study aimed to examine the effects of CPB on salusin-α, salusin-β and apelin-36 bioactive peptides in people who are planned to undergo coronary artery bypass graft (CABG) operation due to coronary artery disease and to explore whether these peptides are produced in human aortic, saphenous and arterial tissues. T...

journal_title：Peptides

authors： Aydin S,Eren MN,Aydin S,Ozercan IH,Dagli AF

更新日期：2012-10-01 00:00:00

abstract：:An identical CRF-related diuretic peptide (Musca-DP) was isolated and characterized from whole-body extracts of the house fly, Musca domestica, and stable fly, Stomoxys calcitrans. The peptide stimulates cyclic AMP production in Manduca sexta Malpighian tubules and increases the rate of fluid secretion by isolated Mus...

journal_title：Peptides

authors： Clottens FL,Holman GM,Coast GM,Totty NF,Hayes TK,Kay I,Mallet AI,Wright MS,Chung JS,Truong O

更新日期：1994-01-01 00:00:00

abstract：:C-type natriuretic peptide (CNP) was recently found in the myocardium, but possible insights into differences between atrium and ventricle production are so far lacking. Our aim was to evaluate, in an experimental model of pacing-induced heart failure (HF), plasma and tissue levels of CNP and mRNA expression of the pe...

journal_title：Peptides

authors： Del Ry S,Cabiati M,Lionetti V,Emdin M,Recchia FA,Giannessi D

更新日期：2008-12-01 00:00:00

abstract：:Apamin is a neurotoxic octadecapeptide from bee venom, which has been shown to inhibit the non-adrenergic, non-cholinergic inhibitory innervation of the smooth muscle of the gut. Since vasoactive intestinal polypeptide (VIP) has been proposed as a possible inhibitory neurotransmitter, the effect of apamin on the recep...

journal_title：Peptides

authors： Fahrenkrug J,Gammeltoft S,Staun-Olsen P,Ottesen B,Sjöquist A

更新日期：1983-03-01 00:00:00

abstract：:Glucagon-related peptides such as glucagon, glucagon-like peptide-1, and oxyntomodulin suppress food intake in mammals and birds. Recently, novel glucagon-like peptide (GCGL) was identified from chicken brain, and a comparatively high mRNA expression level of GCGL was detected in the hypothalamus. A number of studies ...

journal_title：Peptides

authors： Honda K,Saneyasu T,Yamaguchi T,Shimatani T,Aoki K,Nakanishi K,Kamisoyama H

更新日期：2014-02-01 00:00:00

abstract：:Recent pharmacological data strongly support the hypothesis of delta receptor subtypes as mediators of both supraspinal and spinal antinociception (delta 1 and delta 2 receptors). In vitro ligand binding data, which are fully supportive of the in vivo data, are still lacking. A previous study indicated that [3H][D-Ala...

journal_title：Peptides

authors： Xu H,Partilla JS,de Costa BR,Rice KC,Rothman RB

更新日期：1992-11-01 00:00:00

abstract：:Our previous findings that the degree of endotoxin-induced hypotension in the dog is inversely related to ambient temperature (19 degrees through 30 degrees C) and that only increased doses of naloxone are effective at 19 degrees C suggested that opioid activity is also influenced by ambient temperature, increasing in...

journal_title：Peptides

authors： Schoenfeld AD,Lox CD,Chen CH,Lutherer LO

更新日期：1985-01-01 00:00:00

abstract：:The analysis of the spectrum of circular dichroism (CD) of methionine-oxidized bovine parathyroid hormone peptide, bPTH(1-34) revealed that approximately 43% of the orderly conformation (alpha-helix and beta-sheet) was converted into random coil structure. This peptide failed to elicit any hypotensive response in rats...

journal_title：Peptides

authors： Hong BS,Yang MC,Liang JN,Pang PK

更新日期：1986-11-01 00:00:00

abstract：:The hypocretins (1 and 2) have emerged as key regulators of sleep and wakefulness. We developed a high-throughput enzyme immunoassay (EIA) to measure total brain hypocretin levels from large numbers of mice. Hypocretin levels were not altered by circadian time or age. However, significant differences in one or both hy...

journal_title：Peptides

authors： Lin L,Wisor J,Shiba T,Taheri S,Yanai K,Wurts S,Lin X,Vitaterna M,Takahashi J,Lovenberg TW,Koehl M,Uhl G,Nishino S,Mignot E

更新日期：2002-12-01 00:00:00

abstract：:The actions of a behaviorally active luteinizing hormone-releasing hormone fragment, Ac-LHRH(5-10), on CA1 pyramidal cells were studied utilizing conventional intracellular recordings from the in vitro rat hippocampal slice preparation. The behaviorally active fragment (10(-7) M) and the natural decapeptide [LHRH(1-10...

journal_title：Peptides

authors： Chen Y,Wong M,Moss RL

更新日期：1993-09-01 00:00:00

abstract：:Antibiotic therapy for methicillin-resistant Staphylococcus aureus (MRSA) infections is becoming more difficult in hospitals and communities because of strong biofilm-forming properties and multidrug resistance. Biofilm-associated MRSA is not affected by therapeutically achievable concentrations of antibiotics. Theref...

journal_title：Peptides

authors： Dosler S,Mataraci E

更新日期：2013-11-01 00:00:00