Abstract:
:The presence of immunoreactive endothelin (IR-ET) in human saliva and rat parotid gland was investigated by radioimmunoassay. The IR-ET concentration (mean +/- SEM) in saliva taken from normal volunteers was 2.0 +/- 0.2 pmol/l (n = 15). The IR-ET concentration in rat parotid gland was 19.2 +/- 2.2 fmol/g wet weight (n = 10). Fast protein liquid chromatography (FPLC) of human saliva extract revealed 6 peaks; one peak eluting in the void volume, one in a position between ET-1 and -3, and the other four in the positions of synthetic ET-1, -2, -3 and big ET(1-38), respectively. A similar pattern of rat parotid gland extract was noted with FPLC, except that there was no peak after the void volume. Presence of endothelin, a potent growth factor, in saliva and salivary gland points to a role in maintaining the integrity of the oral and gastrointestinal tract mucosa.
journal_name
Peptidesjournal_title
Peptidesauthors
Lam HC,Takahashi K,Ghatei MA,Suda K,Kanse SM,Bloom SRdoi
10.1016/0196-9781(91)90151-esubject
Has Abstractpub_date
1991-07-01 00:00:00pages
883-5issue
4eissn
0196-9781issn
1873-5169pii
0196-9781(91)90151-Ejournal_volume
12pub_type
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