Abstract:
:Peptides influence cardiac dysfunction; however, peptidergic modulation of contractile performance remains relatively uncharacterized. We identified a novel human peptide that modulates mammalian contractile performance. Members of the FMRFamide-related peptide (FaRP) family contain a C-terminal RFamide but structurally variant N-terminal extension. We report human RFamide-related peptide-1 (hRFRP-1) and rat RFRP-1 rapidly and reversibly decreased shortening and relaxation in isolated mammalian cardiac myocytes in a dose dependent manner. The mammalian FaRP, 26RFa, structurally related to RFRP-1 by only an RFamide did not influence myocyte contractile function. The protein kinase C (PKC) inhibitor bisindolylmaleimide-1 blocked hRFRP-1 activity. Pretreatment with pertussis toxin (PTX) did not diminish hRFRP-1 influence on contractile function. In addition, intravenous injection of hRFRP-1 in mice decreased heart rate, stroke volume, ejection fraction, and cardiac output. Collectively these findings are consistent with the conclusion RFRP-1 is an endogenous signaling molecule that activates PKC and acts through a PTX-insensitive pathway to modulate cardiac contractile function. Taken together these negative chronotropic, inotropic, and lusitropic effects of hRFRP-1 are significant; they suggest direct acute cellular and organ-level responses in mammalian heart. This is the first known study to identify a mammalian FaRP with cardio-depressant effects, opening a new area of research on peptidergic modulation of contractile performance. The high degree of RFRP structure conservation from amphibians to mammals, and similarity to invertebrate cardioinhibitory peptides suggests RFRP-1 is involved in important physiological functions. Elucidation of mechanisms involved in hRFRP-1 synthesis, release, and signaling may aid the development of strategies to prevent or attenuate cardiac dysfunction.
journal_name
Peptidesjournal_title
Peptidesauthors
Nichols R,Demers LA,Larsen BM,Robinson D,Converso K,Russell MW,Westfall MVdoi
10.1016/j.peptides.2010.07.012subject
Has Abstractpub_date
2010-11-01 00:00:00pages
2067-74issue
11eissn
0196-9781issn
1873-5169pii
S0196-9781(10)00324-4journal_volume
31pub_type
杂志文章相关文献
PEPTIDES文献大全abstract::Biological and immunological relationships between molt-inhibiting hormone (MIH) activity in eyestalk ganglia extracts of the crab, Cancer antennarius Stimpson, and peptides of the vasopressin-oxytocin family were assessed. Lysine vasopressin (LVP), arginine vasopressin (AVP), vasotocin (VT), and oxytocin (OT) mimicke...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(85)90166-4
更新日期:1985-07-01 00:00:00
abstract::Tachykinins are multifunctional neuropeptides that have been identified in vertebrates as well as invertebrates. The C-terminal FXGXRa-motif constitutes the consensus active core region of invertebrate tachykinins. In Drosophila, two putative G protein-coupled tachykinin receptors have been cloned: DTKR and NKD. This ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2006.06.014
更新日期:2007-01-01 00:00:00
abstract::The definitive function of pancreatic polypeptide in mammalian physiology remains unknown. The identification of specific PP target tissues should be helpful to further investigations into the possible regulatory actions of this peptide. An in vivo radioreceptor assay was used in the rat to locate potential binding si...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(97)00372-0
更新日期:1998-01-01 00:00:00
abstract::Beta-amyloid (Aβ) peptides are secreted from neurons, resulting in extracellular accumulation of Aβ and neurodegeneration of Alzheimer's disease. Because neuronal secretion is fundamental for the release of neurotransmitters, this study assessed the hypothesis that Aβ undergoes co-release with neurotransmitters. Model...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2013.04.020
更新日期:2013-08-01 00:00:00
abstract::Obesity is a chronic inflammatory disease significantly risen worldwide, especially among children. Adipokines, secreted from adipose tissue, are hormones involved in various cellular processes such as energy metabolism and inflammation. Among the others, adiponectin is gaining increasing interest for its insulin-sent...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2014.11.007
更新日期:2015-01-01 00:00:00
abstract::Ethanol (ETOH) has been shown to have pronounced effects on reproductive endocrinology in humans as well as laboratory animals. We have studied the effects of ETOH on the hypothalamic-pituitary-luteinizing hormone (LH) axis, using the male rat as an animal model. In order to better understand the method by which ETOH ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(84)90278-x
更新日期:1984-01-01 00:00:00
abstract::Bradykinin (BK) has been proposed as the principal mediator of hypersensitivity reactions (HSR) in patients dialyzed using negatively charged membranes and concomitantly treated with angiotensin-converting enzyme (ACE) inhibitors. We investigated the metabolism of exogenous BK added to the sera of 13 patients dialyzed...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(99)00020-0
更新日期:1999-01-01 00:00:00
abstract::Mussels have diverse groups of cysteine rich, cationic antimicrobial peptides (AMPs) (defensins, mytilins, myticins, and mytimycin) that constitute an important component of their innate immune defence. Despite the identification and characterization of these AMPs in mussels, the underlying genetic mechanisms that mai...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2008.03.007
更新日期:2008-07-01 00:00:00
abstract::Spasmolytic polypeptide (SP) and intestinal trefoil factor (ITF) are trefoil peptides expressed by gut mucus cells. Using specific antisera we have quantified and characterized the molecular forms and distribution of these peptides in the rat gut. SP predominates in the gastric antrum as a 12 kDa form. ITF (7 kDa) is ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(95)00070-z
更新日期:1995-01-01 00:00:00
abstract::The effect of vasoactive intestinal peptide (VIP) on the nerve-stimulated contraction, tissue oxygenation, lipid peroxidation and antioxidant enzymes activities-superoxide dismutase and catalase was investigated in the rat gastrocnemius muscle exposed to 4 h ischemia-4hr reperfusion. Ischemia caused significant decrea...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(96)00289-6
更新日期:1997-01-01 00:00:00
abstract::In addition to wasp kinins, the wasp venom contains a series of hydrophobic peptides, mastoparans and chemotactic peptides as major peptidergic components. The first major component in the venom is mastoparam. The peptides in the mastoparan family are tetradecapeptide amides which cause degranulation of the mast cells...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(85)90409-7
更新日期:1985-01-01 00:00:00
abstract::We investigated the ability of sulfated cholecystokinin (26-33) (CCK-8) and cholecystokinin (30-33) (CCK-4) to induce taste aversion or avoidance conditioning (TAC) in a one-bottle testing paradigm after either intravenous (i.v.), intracerebroventricular (i.c.v.), or intraperitoneal (i.p.) administration. Significant ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(98)00025-4
更新日期:1998-01-01 00:00:00
abstract::An immunohistochemical mapping study in the brain and upper spinal cord of the turtle Testudo hermanni Gmelin revealed a wide distribution of somatostatin perikarya and fibres. Within the telencephalon, somatostatin perikarya are present in the anterior olfactory nucleus, in the medial, dorsomedial and dorsal cortex, ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(84)90268-7
更新日期:1984-01-01 00:00:00
abstract::A variant form of the vasoactive intestinal polypeptide (VIP) has been isolated. It was found to consist of a molecule which instead of the C-terminal asparagine amide of VIP has a C-terminal extension of Gly-Lys-Arg. This VIP variant displaces VIP in a VIP receptor assay, reacts with N-terminally-directed antisera in...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(88)90149-0
更新日期:1988-05-01 00:00:00
abstract::As the frequent emergence of the resistant bacteria, the development of new agents with a new action mode attracts a great deal of interest. It is now widely accepted that antimicrobial peptides (AMPs) are promising alternatives to conventional antibiotics. In this study, antimicrobial peptide polybia-MPI and its anal...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.11.002
更新日期:2013-01-01 00:00:00
abstract::The presence of the proenkephalin A-derived peptide Met5-enkephalin-Arg6-Gly7-Leu8 was demonstrated throughout the human gastrointestinal tract. Highest concentrations of Met5-enkephalin-Arg6-Gly7-Leu8, as assessed by radioimmunoassay, were measured in the separated muscularis externa, while lower levels were found in...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(86)90087-2
更新日期:1986-09-01 00:00:00
abstract::Although many studies have demonstrated the action of motilin on migrating motor complex by using human subjects and relatively large animals, the precise physiological mechanisms of motilin remain obscure. One reason for the lack of progress in this research field is that large animals are generally not suitable for ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2008.10.006
更新日期:2009-02-01 00:00:00
abstract::Immunohistochemical studies were conducted on sections of cat hypothalamus in order to determine the distribution of neurons containing alpha-melanocyte stimulating hormone and beta-endorphin immunoreactivity. A large number of neurons in the arcuate nucleus were stained after incubation of sections with antisera to e...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(82)90167-x
更新日期:1982-07-01 00:00:00
abstract::The aim of our study was to determine whether a meal modifies the antisecretory response induced by PYY and the structural requirements to elicit antisecretory effects of analogue PYY(22-36) for potential antidiarrhea therapy. The variations in short-circuit current (Isc) due to the modification of ionic transport acr...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(95)02037-3
更新日期:1995-01-01 00:00:00
abstract::The Manduca allatotropin (Mas-AT) gene is expressed as at least three mRNA isoforms that differ from each other by alternative splicing. The location at which the alternative exons are included in the mature mRNAs occur within the open reading frame, so that three different propeptides are predicted as translation pro...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(00)00378-8
更新日期:2001-02-01 00:00:00
abstract::Using a one-bottle taste aversion conditioning paradigm, sulfated cholecystokinin(26-33) (CCK-8) has again been shown to induce taste aversion conditioning in rats. Even though the effective doses of CCK-8 are relatively high, they do not induce as strong an aversion as has been demonstrated with LiCl. This pharmacody...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(95)00001-z
更新日期:1995-01-01 00:00:00
abstract::alpha-MSH stimulates steroid secretion by rat adrenal zona glomerulosa cells and tissues but not fasciculata/reticularis cells when added to in vitro incubations. With glomerulosa cells from control animals on a normal sodium intake, production of corticosterone was significantly stimulated at an alpha-MSH concentrati...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(81)80026-5
更新日期:1981-07-01 00:00:00
abstract::In lieu of H-Dmt-Tic-OH, H-Dmt-analogues included 2-amino-3(1H-benzoimidazol-2-yl)-propionic acid, N(Bzl)Gly, L-octahydroindole-2-carboxylic acid, [3S-(3alpha,4abeta, 8abeta)]-decahydro-3-isoquinoline carboxylic acid, benzimidazole-, pyridoindole- or spiroinden-derivatives, or C-terminally modified. L- or D-Ala, Sar, ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(00)00315-6
更新日期:2000-11-01 00:00:00
abstract::Endogenous hemorphins, derived from degradation of the beta-chain of hemoglobin, lower arterial blood pressure and exert an antinociceptive action in experimental models of nociception. Hemopressin, derived from the alpha-chain of hemoglobin, also decreases blood pressure, but its effects on pain have not been studied...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2004.10.026
更新日期:2005-03-01 00:00:00
abstract::The renin-angiotensin system (RAS) is now recognized as an important modulator of body metabolic processes. The discovery of angiotensin-converting enzyme 2 (ACE2) has renewed interest in the potential therapeutic role of RAS modulation. Recent studies have pointed out the importance of the local balance between ACE/A...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2014.10.005
更新日期:2014-12-01 00:00:00
abstract::We investigated the effect of surgical castration of male rats on the binding of [Tyr(125I)10]VIP to receptors on the anterior pituitary gland, superior mesenteric artery, brain, liver, and prostate gland. In anterior pituitary membranes the maximum number of VIP binding sites was increased whereas binding affinity wa...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(90)90146-v
更新日期:1990-11-01 00:00:00
abstract::A functional study has been performed to characterise the Y receptors responsible for NPY, PYY and PP-stimulated responses in mouse colonic mucosal preparations. Electrogenic ion secretion was stimulated with VIP following which NPY, PYY and PP analogues were, to varying degrees, inhibitory. PYY(3-36), hPP, Gln(23)hPP...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(01)00355-2
更新日期:2001-03-01 00:00:00
abstract::C-type natriuretic peptide (CNP) is assuming increasing importance in cardiovascular disease, and in adults its plasma levels are related to clinical and functional disease severity. Data are scarce regarding the reference values for CNP in infancy. Aim of this study was to assess the reference intervals for CNP in hu...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2011.11.005
更新日期:2012-01-01 00:00:00
abstract::Chemerin is a novel peptide that was identified as a natural ligand for ChemR23. As it has been reported to be involved in the regulation of immune responses and adipogenesis, chemerin may have a variety of physiological functions. Chemerin is synthesized as a precursor (prochemerin) and is proteolytically activated a...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2009.05.030
更新日期:2009-08-01 00:00:00
abstract::This review describes the role of modulation of intracellular adhesion molecule-1 (ICAM-1)/leukocyte function-associated antigen-1 (LFA-1) interaction in controlling autoimmune diseases or inducing immunotolerance. ICAM-1/LFA-1 interaction is essential for T-cell activation as well as for migration of T-cells to targe...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/s0196-9781(03)00083-4
更新日期:2003-03-01 00:00:00