Abstract:
:In lieu of H-Dmt-Tic-OH, H-Dmt-analogues included 2-amino-3(1H-benzoimidazol-2-yl)-propionic acid, N(Bzl)Gly, L-octahydroindole-2-carboxylic acid, [3S-(3alpha,4abeta, 8abeta)]-decahydro-3-isoquinoline carboxylic acid, benzimidazole-, pyridoindole- or spiroinden-derivatives, or C-terminally modified. L- or D-Ala, Sar, or Pro were spacers between aromatic nuclei. Only H-Dmt-(Xaa-)-pyridoindole exhibited high affinities with delta and mu antagonism. The peptides competed equally against [3H]DPDPE (delta agonist) or [3H]N,N(CH3)2-Dmt-Tic-OH (delta antagonist) signaling a single delta binding site. The data confirm the importance of Tic for delta affinity and antagonism, while heterocyclic or heteroaliphatic nuclei, or spacer exert effects on mu- and delta-receptor properties.
journal_name
Peptidesjournal_title
Peptidesauthors
Balboni G,Salvadori S,Guerrini R,Bianchi C,Santagada V,Calliendo G,Bryant SD,Lazarus LHdoi
10.1016/s0196-9781(00)00315-6subject
Has Abstractpub_date
2000-11-01 00:00:00pages
1663-71issue
11eissn
0196-9781issn
1873-5169pii
S0196-9781(00)00315-6journal_volume
21pub_type
杂志文章相关文献
PEPTIDES文献大全abstract::Hypocretin-1 (hcrt-1) and hypocretin-2 (hcrt-2) are two recently discovered hypothalamic neuropeptides. In the present study, using double immunofluorescent techniques, the co-localization of hcrt-1 and hcrt-2 was examined in neuronal soma and fibers/terminals located, respectively, in the cat hypothalamus and brainst...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(02)00084-0
更新日期:2002-08-01 00:00:00
abstract::We examined the mechanism through which leptin increases Na(+), K(+)-ATPase activity in the rat kidney. Leptin was infused under anaesthesia into the abdominal aorta proximally to the renal arteries and then Na(+), K(+)-ATPase activity was measured in the renal cortex and medulla. Leptin (1mug/kgmin) increased Na(+), ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2006.08.010
更新日期:2006-12-01 00:00:00
abstract::A newly developed system of isolated rat colonic epithelial cells was utilized for a comprehensive study of protein synthesis influenced by gastrin. We found that synthetic human gastrin (0.01-100 nM) increased the incorporation of [35S]methionine into proteins within 2 hours. Peak incorporation was observed with 10 n...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(91)90168-o
更新日期:1991-01-01 00:00:00
abstract::Effects of pentobarbital, chlordiazepoxide and ethanol were studied alone and in combination with thyrotropin-releasing hormone (TRH), IM, on punished behavior. Key-peck responses of pigeons were maintained by food presentation under a fixed-interval 3-min schedule in which every 30th response produced shock. Moderate...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(84)90026-3
更新日期:1984-07-01 00:00:00
abstract::Heat-stable enterotoxin b (STb) of Escherichia coli is a 48-amino acid basic, disulfide-bonded peptide that causes intestinal secretion in experimental animal models. Recent evidence suggests that the in vivo mechanism of STb action involves release of 5-hydroxytryptamine (5-HT) and production of prostaglandin E2 (PGE...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(96)00033-2
更新日期:1996-01-01 00:00:00
abstract::The purpose of this study is to elucidate the mechanism of action and site of action of calcitonin gene-related peptide (CGRP) and its effects on calcium concentrations in two types of cardiomyocytes, neonatal and adult, by employing real-time fluorescence imaging. CGRP caused an increase in intramyocytic calcium with...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2005.04.021
更新日期:2005-11-01 00:00:00
abstract::The 41-residue corticotropin releasing factor (CRF) was synthesized by the solid phase method. The synthetic CRF and arginine vasopressin (AVP) were examined for ACTH releasing activity and effects on the release of 5 other pituitary hormones in vivo and in vitro. Injection of the CRF into pharmacologically blocked ra...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(81)80099-x
更新日期:1981-01-01 00:00:00
abstract::The functional help provided by four cross-linked synthetic peptides from HIV-1 Gag structural proteins was investigated in the mouse model. These peptides, selected upon non-self-criteria, are not predicted as T epitopes by classical prediction methods such as the Rothbard consensus or the amphipathy rule. Priming mi...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(94)90055-8
更新日期:1994-01-01 00:00:00
abstract::A 41 amino acid peptide, probably identical in structure to human corticotropin releasing factor, was isolated from 70 equine hypothalami by methanol extraction, immunoaffinity chromatography and single step of reverse phase HPLC. The amino acid sequence was determined by gas phase sequence analysis. Probable carboxyl...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(91)90230-m
更新日期:1991-11-01 00:00:00
abstract::The present study investigated the effects of neuropeptide Y (NPY) on food intake and body temperature (Tbo) in free-feeding unrestrained rats following injection into the medial hypothalamic paraventricular nucleus (PVN) or the lateral perifornical hypothalamus (PFH). NPY (78-235 pmol) or saline was infused unilatera...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(95)00020-k
更新日期:1995-01-01 00:00:00
abstract::Effects of rat and human calcitonin gene-related peptide (r alpha CGRP and h beta CGRP, respectively) upon uterine contractile force were investigated using uterine horns from nonpregnant rats, r alpha CGRP and h beta CGRP were equipotent (pD2 = 8.85-9.09) in inhibiting spontaneous and electrically evoked uterine cont...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(90)90006-q
更新日期:1990-09-01 00:00:00
abstract::The effects of CCK-8s and desulfated CCK-8 at concentrations ranging from 10(-14) to 10(-6) M were studied in vitro on several functions of human peripheral neutrophils: adherence to substrate, mobility (spontaneous and directed by a chemical gradient or chemotaxis), ingestion of inert particles (latex beads) or cells...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(96)00338-5
更新日期:1997-01-01 00:00:00
abstract::Expression of the two gonadotropin-releasing hormone homologue peptides GnRHI and GnRHII and their receptor GnRHR has been demonstrated in a number of malignancies. In hormone-dependent breast cancer, GnRH analogs are used for therapy in premenopausal women. Gene expression of GnRHI, II and R was studied in breast bio...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.12.016
更新日期:2013-04-01 00:00:00
abstract::Chronic administration of neuroleptics has been shown to affect the endogenous levels, mRNA, posttranslational processing, and metabolism of neuropeptides in specific regions of rat brain. Neutral endopeptidase 24.11 (NEP) is known to metabolize a variety of neuropeptide substrates, including the enkephalins and neuro...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(93)90080-z
更新日期:1993-09-01 00:00:00
abstract::Of twelve dipeptides tested, only the Trp containing peptides Val-Trp and its reverse peptide Trp-Val showed a xanthine oxidase (XO) inhibitory activity. Studies with Val and Trp revealed that XO inhibition was mainly attributed to the Trp residue. No significant difference (P ≥ 0.05) was found for the XO inhibitory p...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.07.030
更新日期:2012-10-01 00:00:00
abstract::Glucagon-like-peptide-1 (GLP-1) is a proglucagon-derived peptide expressed in the intestinal enteroendocrine-L cells and released after meal ingestion. GLP-1 reduces postprandial glycemia not only by its hormonal effects, but also by its inhibitory effects on gastrointestinal motility. Recently, we showed that GLP-1 a...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2010.09.028
更新日期:2011-01-01 00:00:00
abstract::Many animal studies show an enhancing effect of vasopressin (VP) on memory, but not all human studies could confirm this finding. This study examined the influence of post-learning administration of VP (40 IU, intranasally) on the consolidation of declarative memories in healthy humans during different intervals of sl...
journal_title:Peptides
pub_type: 临床试验,杂志文章
doi:10.1016/s0196-9781(01)00625-8
更新日期:2002-03-01 00:00:00
abstract::Previous studies have shown that the nervous system and other tissues of molluscs contain a number of peptides that potently excite molluscan hearts. Two such peptides, termed small cardioactive peptides A and B (SCPA and SCPB) are present in large quantities in the nervous system of Aplysia. These peptides are widely...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(87)90184-7
更新日期:1987-01-01 00:00:00
abstract::Multiple-time regression analysis has been used to study the influx of radiolabeled peptides and polypeptides across the blood-brain barrier (BBB). This study used both tritiated and iodinated leptin to clarify several issues associated with these measurements. Recombinant murine leptin was radiolabeled with 3H by der...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(01)00569-1
更新日期:2001-12-01 00:00:00
abstract::Interdigestive migrating contractions (IMC) were analyzed for their occurrence interval, duration, migrating velocity, and frequently in long term records obtained by means of chronically implanted force transducers in the main stomach and the extrinsically denervated fundic pouches or in the intact jejunum and the ex...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(81)90035-8
更新日期:1981-01-01 00:00:00
abstract::Defensins are essentially ancient natural antibiotics with potent activity extending from lower organisms to humans. They can inhibit the growth or virulence of micro-organisms directly or indirectly enhance the host's immune system. The successful prediction of defensin peptides will provide very useful information a...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2009.06.032
更新日期:2009-10-01 00:00:00
abstract::The synthesis is described of an analogue of the locust CRF-like diuretic peptide in which methionine in positions 1,3, and 13 is replaced by isosteric methyl-homoserine residues. This analogue has been tested for biological activity on Malpighian tubules in vitro, and feeding behavior in vivo. It is highly active in ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2003.09.010
更新日期:2003-10-01 00:00:00
abstract::Short cell penetrating peptides (CPP) are widely used in vitro to transduce agents into cells. But their systemic effect has not been yet studied in detail. We studied the systemic effect of the cell penetrating peptides, penetratin, transportan and pro-rich, on rat hemodynamic functions. Intra-arterial monitoring of ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2011.09.017
更新日期:2011-12-01 00:00:00
abstract::An antifungal protein was isolated from the mushroom Tricholoma giganteum var. golden blessings. The protocol included ion exchange chromatography on DEAE-cellulose, affinity chromatography on Affi-gel blue gel, ion exchange chromatography on CM-cellulose, and gel filtration by fast protein liquid chromatography on Su...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2004.11.009
更新日期:2005-04-01 00:00:00
abstract::This report reviews the hypothesis that peptides play a role in appetite modulation, stressing that the available evidence is predominantly pharmacological and thus caution needs to be taken in assigning physiological significance at this time. Two peptide systems have been postulated--a peripheral satiety system, typ...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/0196-9781(85)90153-6
更新日期:1985-01-01 00:00:00
abstract::In this study we examined the effects of 2% saline loading (S), partial restriction of water consumption (R) or a combination of S or R with dexamethasone (DEX) treatment for 14 days on corticotropin releasing factor (CRF)-41 content of the neurointermediate lobe (NIL) and supraoptic nuclei (SON) of male Wistar rats. ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(90)90109-i
更新日期:1990-01-01 00:00:00
abstract::Antimicrobial peptides produced by multicellular organisms protect against pathogenic microorganisms, whereas such peptides produced by bacteria provide an ecological advantage over competitors. Certain antimicrobial peptides of metazoan origin are also toxic to eukaryotic cells, with preference for a variety of cance...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2010.04.010
更新日期:2010-07-01 00:00:00
abstract::Phalloidin staining F-actin was used to image muscle fiber arrangements present in the reproductive system of the adult female Rhodnius prolixus. A mesh of muscle fibers encircles the ovaries whereas a criss-cross pattern of finer muscle fibers covers each ovariole. Two layers of muscle fibers (arranged longitudinally...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2013.04.003
更新日期:2014-03-01 00:00:00
abstract::Previous studies have shown that different calcitonins interact with planar lipid membranes to form ion channels. In this study, glycosylation of eel calcitonin (eCt) at different positions (Ct3-GlcNAc, Ct14-GlcNAc, Ct20-GlcNAc, Ct26-GlcNAc) is shown to preserve molecular structure and slightly change the energy of in...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2005.09.011
更新日期:2006-04-01 00:00:00
abstract::The presence of alpha-hANP immunoreactive material in human heart and plasma was investigated with a specific and sensitive radioimmunoassay and immunohistochemical method. It was found that alpha-hANP immunoreactive staining of specific atrial granules was located around the nucleus of atrial cardiocytes. No immunore...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(86)90057-4
更新日期:1986-01-01 00:00:00