Abstract:
:Defensins are essentially ancient natural antibiotics with potent activity extending from lower organisms to humans. They can inhibit the growth or virulence of micro-organisms directly or indirectly enhance the host's immune system. The successful prediction of defensin peptides will provide very useful information and insights for the basic research of defensins. In this study, by selecting the N-peptide composition of reduced amino acid alphabet (RAAA) obtained from structural alphabet named Protein Blocks as the feature parameters, the increment of diversity (ID) is firstly developed to predict defensins family and subfamily. The jackknife test based on 2-peptide composition of reduced amino acid alphabet (RAAA) with 13 reduced amino acids shows that the overall accuracy of prediction are 91.36% for defensin family, and 94.21% for defensin subfamily. The results indicate that ID_RAAA is a simple and efficient prediction method for defensin peptides.
journal_name
Peptidesjournal_title
Peptidesauthors
Zuo YC,Li QZdoi
10.1016/j.peptides.2009.06.032subject
Has Abstractpub_date
2009-10-01 00:00:00pages
1788-93issue
10eissn
0196-9781issn
1873-5169pii
S0196-9781(09)00273-3journal_volume
30pub_type
杂志文章相关文献
PEPTIDES文献大全abstract::Previous corticotropin releasing factor 1 (CRF1) receptor characterization has been performed using radiolabeled agonists, which bind predominantly the receptor-G-protein complex. The pharmacological profile of other receptor states, and their abundance, remain poorly characterized. Here we investigated the affinity s...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2003.09.002
更新日期:2003-12-01 00:00:00
abstract::We studied circulating levels of endothelin-1, catecholamines and nitric oxide after a mental arithmetic test in 14 patients with early ischemic lesions of the extremities due to systemic sclerosis and slightly impaired peripheral vascular flow. The test induced an increase (P<0.01) in blood pressure, heart rate, endo...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2005.06.001
更新日期:2005-12-01 00:00:00
abstract::The rat central and peripheral nervous system contains a widespread distribution of BPP-like immunoreactive neurons. Some of these neurons coexist with a catecholamine, probably mostly NE. This peptide appears to be releaseable by nerve stimulation. Catecholamine releasing agents such as reserpine do not appear to dep...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(82)90128-0
更新日期:1982-05-01 00:00:00
abstract::We demonstrated the production and release of a peptide structurally identical with porcine and bovine VIP-28 in human neuroblastoma NB-OK-1 cell line. In the cells, VIP-like immunoreactive (IR-VIP) components of 8 K dalton (Kd), 11 Kd, 18 Kd and 30 Kd were also detected and the 8 Kd and 18 Kd components were apparent...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(84)90199-2
更新日期:1984-03-01 00:00:00
abstract::We evaluated behavior and cognitive performance in a line of transgenic mice that overexpress the rat gene for vasopressin. Open field testing revealed greatest habituation in homozygous mice. Passive avoidance performance indicated equal learning and memory ability of transgenic compared to normal mice. Drinking beha...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(95)02047-0
更新日期:1995-01-01 00:00:00
abstract::To identify male-specific genes that could be involved in male development, we screened a subtracted male reproductive tract library and isolated a novel gene named Mar-Mrr (M. rosenbergii male reproduction-related gene). The Mar-Mrr cDNA sequence consists of 683 nucleotides with a 333 nucleotide open reading frame, e...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2005.09.004
更新日期:2006-04-01 00:00:00
abstract::Previous studies have shown that the nervous system and other tissues of molluscs contain a number of peptides that potently excite molluscan hearts. Two such peptides, termed small cardioactive peptides A and B (SCPA and SCPB) are present in large quantities in the nervous system of Aplysia. These peptides are widely...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(87)90184-7
更新日期:1987-01-01 00:00:00
abstract::A comparison of the conformational characteristics of the related hormones [Nle(15)] gastrin-17 and [Tyr(9)-SO(3)] cholecystokinin-15, in membrane-mimetic solutions of dodecylphosphocholine micelles and water, was undertaken using NMR spectroscopy to investigate the possibility of a structural motif responsible for th...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2007.09.008
更新日期:2007-11-01 00:00:00
abstract::Heat-stable enterotoxin b (STb) of Escherichia coli is a 48-amino acid basic, disulfide-bonded peptide that causes intestinal secretion in experimental animal models. Recent evidence suggests that the in vivo mechanism of STb action involves release of 5-hydroxytryptamine (5-HT) and production of prostaglandin E2 (PGE...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(96)00033-2
更新日期:1996-01-01 00:00:00
abstract::Pituitary Adenylate-Cyclase Activating Polypeptide (PACAP) and Tac1 gene-encoded tachykinins (substance P: SP, neurokinin A: NKA) are expressed in capsaicin-sensitive nerves, but their role in nociception, inflammation and vasoregulation is unclear. Therefore, we investigated the function of these neuropeptides and th...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2013.03.003
更新日期:2013-05-01 00:00:00
abstract::We recently reported the direct inhibitory effect of adrenomedullin on caecal circular smooth muscle cells via cAMP system. This study was designed to determine whether the structurally related peptides to adrenomedullin (i.e.; calcitonin gene-related peptide (CGRP), calcitonin, and amylin) can inhibit the cholecystok...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(01)00416-8
更新日期:2001-06-01 00:00:00
abstract::Cone snails have evolved an assortment of venom peptides as an evolutionary strategy for rapid prey immobilization and defence. Earlier studies estimated approximately 100 conopeptides per species. In this study we optimized liquid chromatography and electrospray ionization mass spectrometry for the detection of conop...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2009.03.019
更新日期:2009-07-01 00:00:00
abstract::In a previous study, we found that calcitonin gene-related peptide (CGRP) could be induced by proinflammatory factor IL-1beta in A549 human type II alveolar (AEII) epithelial cells. We investigated the mechanism of IL-1beta-induced CGRP secretion and found that the PKC-p38 MAPK-NF-kappaB pathway was involved. In the p...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2007.03.021
更新日期:2007-06-01 00:00:00
abstract::Peptides have the potential to be potent pharmaceutical agents for the treatment of many central nervous system derived maladies. Unfortunately peptides are generally water-soluble compounds that will not enter the central nervous system, via passive diffusion, due to the existence of the blood-brain barrier. Peptides...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/s0196-9781(01)00537-x
更新日期:2001-12-01 00:00:00
abstract::The effect of melanin-concentrating hormone (MCH) on the release of alpha-melanocyte stimulating hormone (alpha-MSH) from the tilapia pituitary gland was studied in vitro. In a superfusion set up, 10 nM to 1 microM synthetic salmon MCH caused a concentration-dependent inhibition of alpha-MSH release from tilapia neuro...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(95)00063-p
更新日期:1995-01-01 00:00:00
abstract::Human bombesin receptors, GRPR and NMBR, are two of the most frequently overexpressed G-protein-coupled-receptors by lung-cancers. Recently, GRPR/NMBR are receiving considerable attention because they act as growth factor receptors often in an autocrine manner in different lung-cancers, affect tumor angiogenesis, thei...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2018.01.016
更新日期:2018-03-01 00:00:00
abstract::Macrophage foam cell formation, characterized by cholesterol ester accumulation catalyzed by acyl-CoA:cholesterol acyltransferase 1 (ACAT1), is the hallmark of early atherogenesis. We previously demonstrated the suppressive effects of incretins, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic poly...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2013.12.015
更新日期:2014-04-01 00:00:00
abstract::A novel peptide hormone, atrial natriuretic factor (ANF), was recently isolated and characterized in mammalian atria. This hormone has potent natriuretic diuretic and vasorelaxant activities. Since ANF bioactivity was initially found in atria but not in ventricles, it was assumed that the ANF gene is specifically expr...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(86)90145-2
更新日期:1986-11-01 00:00:00
abstract::Kallikrein-related peptidases (KLKs) are a group of serine proteases, expressed in several tissues. Their activity is regulated by inhibitors including members of the serine protease of Kazal-type (SPINK) family. Recently, we discovered that SPINK6 is expressed in human skin and inhibits KLK5, KLK7, KLK14 but not KLK8...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2011.03.009
更新日期:2011-06-01 00:00:00
abstract::We have examined the distributions of ACTH, CCK and enkephalin immunoreactive nerves in the rat central nervous system and compared the pattern obtained with that of opiate receptors. In addition, a radioreceptor assay has been employed for studying the possible functional interactions between these peptides and opiat...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/0196-9781(81)90050-4
更新日期:1981-01-01 00:00:00
abstract::We administered prolactin-releasing peptide (PrRP) or anti-PrRP antiserum to goldfish in fresh water and analyzed their effects on prolactin and osmoregulatory mechanisms. The pituitary mRNA level of prolactin increased by PrRP but decreased by anti-PrRP. The rate of water inflow in the gills decreased by PrRP and inc...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2005.06.034
更新日期:2006-05-01 00:00:00
abstract::Parasitic worms come from two very different phyla-Platyhelminthes (flatworms) and Nematoda (roundworms). Although both phyla possess nervous systems with highly developed peptidergic components, there are key differences in the structure and action of native neuropeptides in the two groups. For example, the most abun...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/s0196-9781(99)00093-5
更新日期:1999-01-01 00:00:00
abstract::This study evaluated the physiological importance of Angiotensin-(1-7) receptor Mas on reflex control of circulation. Experiments were performed in male Mas-knockout (Mas-KO) and Wild Type (WT) conscious mice (12-20 wk of age). Baroreceptor reflex was evaluated by the bradycardic response induced by phenylephrine (0.2...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2010.06.030
更新日期:2010-10-01 00:00:00
abstract::Rhoptries are specialized secretory organelles found in all members of the genus Plasmodium whose proteins have been considered as promising vaccine candidates due to their involvement in cell invasion and the formation of the parasitophorous vacuole (PV). The Plasmodium falciparum Pf34 protein was recently identified...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2010.07.009
更新日期:2010-11-01 00:00:00
abstract::The cell adhesion molecule, N-cadherin plays a pivotal role in many biological and disease processes. Drugs that modulate N-cadherin function should therefore be useful therapeutic agents. We have used phage display technology to identify amino acid sequences capable of binding to N-cadherin. All of these sequences ha...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2008.06.025
更新日期:2008-11-01 00:00:00
abstract::The distributions of neuropeptides in paraffin-embedded tissue sections (PETS) of the eyestalk, brain, and thoracic ganglia of the shrimp Penaeus monodon were visualized by imaging mass spectrometry (IMS). Peptide signals were obtained from PETS without affecting morphological features. Twenty-nine neuropeptides compr...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2011.03.021
更新日期:2012-03-01 00:00:00
abstract::Neurotensin exerts its actions in the central nervous system and the periphery through three identified receptors. Two of them, the NTS2 and NTS3, display unusual properties either because of their complex signal transduction mechanisms (NTS2) or because of their structural composition as a non-G-protein-coupled recep...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2006.04.026
更新日期:2006-10-01 00:00:00
abstract::Copeptin can reflect individual's stress state and are correlated with poor outcome of critical illness. The occurrence of postoperative delirium (POD) and cognitive dysfunction (POCD) is associated with worse outcome after coronary artery bypass graft (CABG) surgery. The present study aimed to investigate the ability...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2014.06.016
更新日期:2014-09-01 00:00:00
abstract::Discovering the informational rule(s) underlying structure-function relationships in the protein language is at the core of biology. Current theories have proven inadequate to explain the origins of biological information such as that found in nucleotide and amino acid sequences. Here, we demonstrate that the informat...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2010.02.003
更新日期:2010-05-01 00:00:00
abstract::Parathyroid hormone (PTH) has been shown to have actions within the brain, suggesting the presence of central PTH receptors. This possibility was examined by determining the binding of 125I-labeled [Nle8,18,Tyr34]bovine PTH to the plasma membranes of rat and rabbit brains. Specific binding of the tracer to membranes o...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(93)90174-f
更新日期:1993-11-01 00:00:00