Abstract:
:Neurotensin (NT) produces behavioral and physiological effects, including analgesia and hypotheria, when administered into the CNS. Fischer and Lewis rats exhibit differential behavioral responses to central NT receptor activation. To further characterize these differences, we assessed central NT-induced analgesia and hypothermia in independent groups of rats from each strain. Fischer and Lewis rats showed a similar dose-orderly analgesic response in a hot-plate test. Such an isosensitivity was not observed for NT-induced hypothermia. Although NT produced a dose-orderly decrease in mean rectal temperature in both strains, the magnitude of the hypothermic response was significantly smaller in Fischer than in Lewis rats. These findings provide further evidence of genetic differences in central neurotensinergeric neurotransmission in these two strains.
journal_name
Peptidesjournal_title
Peptidesauthors
Bauco P,Rompré PPdoi
10.1016/j.peptides.2003.06.004subject
Has Abstractpub_date
2003-08-01 00:00:00pages
1189-94issue
8eissn
0196-9781issn
1873-5169pii
S0196978103002596journal_volume
24pub_type
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