Abstract:
:Several cardioactive peptides from the pulmonate snail Helix aspersa were tested for their effects on myocardial cAMP levels, but only the family of small cardioactive peptides (SCPs) were clearly effective. SCP increased cAMP in a dose dependent manner; the time course was phasic. The structure-activity relations of this effect were examined with a set of 3 synthetic analogs having characteristics, at the carboxyterminal, of both the SCPs and FMRFamide-related peptides. The adenylate cyclase activator forskolin mimicked the mechanical effect of SCPs on the heartbeat. We conclude that the effect of SCPs on the Helix heart may be mediated by cAMP.
journal_name
Peptidesjournal_title
Peptidesauthors
Reich G,Doble KE,Price DA,Greenberg MJdoi
10.1016/s0196-9781(96)00335-xsubject
Has Abstractpub_date
1997-01-01 00:00:00pages
355-60issue
3eissn
0196-9781issn
1873-5169pii
S0196-9781(96)00335-Xjournal_volume
18pub_type
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