Systemic hepcidin quantified with LC-MS/MS in dementia in association with disease pathology and severity and with structural changes in the brain.

abstract：:We have studied the in vitro effect of VIP and histamine on ultrastructure of the parietal cells in isolated guinea pig fundic glands. The morphological changes induced by histamine in the parietal cells can be compared to those observed after histamine stimulation in vivo or in vitro on gastric mucosa preparations. I...

journal_title：Peptides

authors： Anteunis A,Gespach C,Astesano A,Emami S,Robineaux R,Rosselin G

更新日期：1984-03-01 00:00:00

abstract：:alpha-MSH stimulates steroid secretion by rat adrenal zona glomerulosa cells and tissues but not fasciculata/reticularis cells when added to in vitro incubations. With glomerulosa cells from control animals on a normal sodium intake, production of corticosterone was significantly stimulated at an alpha-MSH concentrati...

journal_title：Peptides

authors： Vinson GP,Whitehouse BJ,Thody AJ

更新日期：1981-07-01 00:00:00

abstract：:A short neuropeptide F (sNPF) precursor and a sNPF receptor (sNPFR) were characterized for the mosquito, Anopheles gambiae. The sNPFR was expressed in CHO-K1 cells, and it exhibited high affinity binding, IC(50) approximately 3-5 nM, for specific sNPFs. sNPF1 potently inhibited forskolin-stimulated cAMP production by ...

journal_title：Peptides

authors： Garczynski SF,Crim JW,Brown MR

更新日期：2007-01-01 00:00:00

abstract：:A large body of evidence suggests a relationship between depression and coronary heart disease (CHD). Angiotensin-Ⅱ (Ang-Ⅱ) and angiotensin-(1-7) [Ang-(1-7)] are considered to exert biological effects in both conditions. Here, we aimed to determine the role of Ang-Ⅱ and Ang-(1-7) in the occurrence of comorbid depressi...

journal_title：Peptides

authors： Han W,Wei Z,Dang R,Guo Y,Zhang H,Geng C,Wang C,Feng Q,Jiang P

更新日期：2020-09-01 00:00:00

abstract：:Cellular uptake of [125I] labelled DSIP at the luminal interface of the blood-brain barrier (BBB) was studied in the ipsilateral perfused in situ guinea pig forebrain. Regional unidirectional transfer constants (Kin) calculated from the multiple-time brain uptake analysis were 0.93, 1.33 and 1.66 microliter.min-1 g-1 ...

journal_title：Peptides

authors： Zlokovic BV,Susic VT,Davson H,Begley DJ,Jankov RM,Mitrovic DM,Lipovac MN

更新日期：1989-03-01 00:00:00

abstract：:The objective of this study was to investigate absorption enhancing approaches for systemic delivery of methionine enkephalin via the nose. Absorption promotion of methionine enkephalin in the presence of protease inhibitors (bestatin, puromycin) and absorption enhancers (glycocholate, dimethyl-beta-cyclodextrin) were...

journal_title：Peptides

authors： Agu RU,Vu Dang H,Jorissen M,Kinget R,Verbeke N

更新日期：2004-04-01 00:00:00

abstract：:In the present study, the newly synthesized TRH analog (L-pGlu-(2-propyl)-L-His-l-ProNH(2); NP-647) was evaluated for its effects in in vitro (oxygen glucose deprivation (OGD)-, glutamate- and H(2)O(2)-induced injury in PC-12 cells) and in vivo (transient global ischemia) models of cerebral ischemic injury. PC-12 cell...

journal_title：Peptides

authors： Rajput SK,Siddiqui MA,Kumar V,Meena CL,Pant AB,Jain R,Sharma SS

更新日期：2011-06-01 00:00:00

abstract：:Somatostatin has been proposed as a regulatory peptide of nutrient entry and fuel homeostasis because of its ability to inhibit the release of substances involved in food digestion and metabolism. The aim of the study was to evaluate the somatostatin response to a test meal in type I diabetics at the clinical onset of...

journal_title：Peptides

authors： Uccioli L,Ghirlanda G,Cotroneo P,Bianchini G,Manto A,Solini A,Annese V,Greco AV

更新日期：1986-01-01 00:00:00

abstract：:Low-density lipoprotein (LDL) concentrations have been linked to altered responses to endogenous vasodilators and vasoconstrictors. We evaluated retrospectively the relationship between LDL and vasoconstrictor (endothelin-1, phenylephrine) responsiveness of the forearm vasculature in 15 elderly healthy volunteers with...

journal_title：Peptides

authors： Romerio SC,Linder L,Flammer J,Haefeli WE

更新日期：2000-06-01 00:00:00

abstract：:Obstructive jaundice (OJ) increases the risk of liver injury and sepsis, leading to increased mortality. Cholestatic liver injury is associated with a downregulation of hepcidin expression levels. In fact, hepcidin has an important antimicrobial effect, especially against Escherichia coli. It is unknown whether supple...

journal_title：Peptides

authors： Huang YH,Yang YL,Tiao MM,Kuo HC,Huang LT,Chuang JH

更新日期：2012-06-01 00:00:00

abstract：:We have previously described a 25mer anti-hypertensive peptide, previously named TsHpt-I (Tityus serrulatus Hypotensin-I), now Ts14, as an agonist of B2 kinin receptor. Bradykinin is known to play physiological roles in angiogenic, inflammatory, and fibrogenic processes, mostly mediated by B2 receptor. Therefore, we i...

journal_title：Peptides

authors： Cassini-Vieira P,Felipetto M,Prado LB,Verano-Braga T,Andrade SP,Santos RAS,Teixeira MM,de Lima ME,Pimenta AMC,Barcelos LS

更新日期：2017-12-01 00:00:00

abstract：:While the circadian rhythm of pituitary adrenocorticotropin (ACTH) secretion has been well characterized, the ultradian rhythm has been less thoroughly investigated. To study the episodic nature of ACTH secretion, unrestrained, unanesthetized rats were bled continuously through indwelling jugular venous cannulae and b...

journal_title：Peptides

authors： Carnes M,Brownfield MS,Kalin NH,Lent S,Barksdale CM

更新日期：1986-03-01 00:00:00

abstract：:Antimicrobial peptides produced by multicellular organisms protect against pathogenic microorganisms, whereas such peptides produced by bacteria provide an ecological advantage over competitors. Certain antimicrobial peptides of metazoan origin are also toxic to eukaryotic cells, with preference for a variety of cance...

journal_title：Peptides

authors： Sand SL,Oppegård C,Ohara S,Iijima T,Naderi S,Blomhoff HK,Nissen-Meyer J,Sand O

更新日期：2010-07-01 00:00:00

abstract：:The UII and urotensin II-related peptide (URP) genes belong to the same superfamily as the somatostatin gene. It has been previously shown that somatostatin activates the UII-receptor (UTR). In contrast, the possible interaction between UII and URP and somatostatin receptors has remained scarcely analyzed. Herein, we ...

journal_title：Peptides

authors： Malagon MM,Molina M,Gahete MD,Duran-Prado M,Martinez-Fuentes AJ,Alcain FJ,Tonon MC,Leprince J,Vaudry H,Castaño JP,Vazquez-Martinez R

更新日期：2008-05-01 00:00:00

abstract：:Angiotensin (Ang)--a peptide that is part of the renin-angiotensin system-induces vasoconstriction and a subsequent increase in blood pressure; Ang peptides, especially AngII, can also act as potent pro-inflammatory mediators. Platelet-activating factor (PAF) is a potent phospholipid mediator that is implicated in man...

journal_title：Peptides

authors： Sato A,Yokoyama I,Ebina K

更新日期：2015-11-01 00:00:00

abstract：:In the adrenal gland all components of the renin-angiotensin system (RAS) are expressed in both the adrenal cortex and the adrenal medulla. In this review evidence shall be presented that a local secretory RAS exists in the adrenal cortex that stimulates aldosterone production and serves as an amplification system for...

journal_title：Peptides

authors： Peters J

更新日期：2012-04-01 00:00:00

abstract：:Recent studies have identified compounds with reduced efficacy relative to nociceptin/orphanin FQ at the opioid-like receptor ORL1. Utilizing stimulation of [(35)S]GTPgammaS binding as in vitro assays, it was determined that both [Phe(1)psi(CH(2)-NH)Gly(2)]N/OFQ(1-13)NH(2) and the hexapeptide Ac-RYYRIK-NH(2) act as pa...

journal_title：Peptides

authors： Burnside JL,Rodriguez L,Toll L

更新日期：2000-07-01 00:00:00

abstract：:The in vitro activity of six polycationic peptides, buforin II, cecropin P1, indolicidin, magainin II, nisin, and ranalexin, were evaluated against several clinical isolates of gram-positive and gram-negative aerobic bacteria, yeasts, Pneumocystis carinii and Cryptosporidium parvum, by using microbroth dilution method...

journal_title：Peptides

authors： Giacometti A,Cirioni O,Barchiesi F,Del Prete MS,Scalise G

更新日期：1999-11-01 00:00:00

abstract：:The effects of alpha-neo-endorphin on mouse behavior were investigated by using a multi-dimensional behavioral analyser (Animex II) which classifies animal's movements into nine degrees. The intracerebral injection of alpha-neo-endorphin (30 micrograms) significantly decreased the 1/1, 1/2 and 1/4 sizes of movement (l...

journal_title：Peptides

authors： Ukai M,Kameyama T

更新日期：1984-01-01 00:00:00

abstract：:Subpopulations of dopamine (DA) neurons in the ventral mesencephalon have been reported to contain cholecystokinin (CCK) and neurotensin (NT), giving rise to DA, DA/NT, NT/CCK and DA/CCK/NT projections. More precisely, colocalized DA/CCK neurons project mainly to the caudal part of the medial nucleus accumbens, wherea...

journal_title：Peptides

authors： Heidbreder C,Gewiss M,De Mot B,Mertens I,De Witte P

更新日期：1992-05-01 00:00:00

abstract：:Guinea pig VIP differs from VIP of several mammals by its amino acids in positions 5, 9, 19 and 26. We tested a) its ability to occupy VIP receptors in liver and lung membranes of rat and guinea pig and in the human lymphoblastic SUP-T1 cell line and b) the ensuing adenylate cyclase stimulation. In liver and lung memb...

journal_title：Peptides

authors： Cauvin A,Buscail L,Gourlet P,De Neef P,Robberecht P,Yanaihara N,Christophe J

更新日期：1991-01-01 00:00:00

abstract：:Three neurotensin (NT) receptors have been cloned to date, two of which, NTS1 and NTS2, belong to the family of seven transmembrane domain receptors coupled to G proteins (GPCRs). NTS1 and NTS2 may activate multiple signal transduction pathways, involving several G proteins. However, whereas NT acts as an agonist towa...

journal_title：Peptides

authors： Pelaprat D

更新日期：2006-10-01 00:00:00

abstract：:A variant form of the vasoactive intestinal polypeptide (VIP) has been isolated. It was found to consist of a molecule which instead of the C-terminal asparagine amide of VIP has a C-terminal extension of Gly-Lys-Arg. This VIP variant displaces VIP in a VIP receptor assay, reacts with N-terminally-directed antisera in...

journal_title：Peptides

authors： Gafvelin G,Andersson M,Dimaline R,Jörnvall H,Mutt V

更新日期：1988-05-01 00:00:00

abstract：:The effect and mode of action of pituitary adenylate cyclase activating polypeptide (PACAP) were studied in rat ileal strips. PACAP relaxed, concentration dependently, rat ileum and was 50 times more potent than the structurally related vasoactive intestinal polypeptide (VIP). The inhibitory action of PACAP was not mo...

journal_title：Peptides

authors： Katsoulis S,Clemens A,Schwörer H,Creutzfeldt W,Schmidt WE

更新日期：1993-05-01 00:00:00

abstract：:Nesfatin-1 is well established to reduce food intake upon brain injection in rats, while in mice its anorexigenic action and brain expression are largely unexplored. We characterized the influence of intracerebroventricular (icv) and peripheral (intraperitoneal, ip, subcutaneous, sc) injection of nesfatin-1 on dark ph...

journal_title：Peptides

authors： Goebel M,Stengel A,Wang L,Taché Y

更新日期：2011-01-01 00:00:00

abstract：:We previously demonstrated that intracerebroventricular (i.c.v.) administration of the substance P (SP) aminoterminal fragment SP(1-7) attenuates the expression of morphine withdrawal in the male rat. In this study we have used a synthetic analogue of this peptide, i.e. the SP(1-7) amide showing higher binding potency...

journal_title：Peptides

authors： Zhou Q,Carlsson A,Botros M,Fransson R,Sandström A,Gordh T,Hallberg M,Nyberg F

更新日期：2009-12-01 00:00:00

abstract：:Human Zonulin, related to the Zonula occludens toxin of Vibrio cholerae, regulates intestinal permeability and is induced in inflammatory disorders of the lower GI tract. Gastroesophageal reflux disease (GERD) is associated with an impairment of epithelial barrier function. Here, we studied expression of zonulin in th...

journal_title：Peptides

authors： Wex T,Mönkemüller K,Kuester D,Fry L,Kandulski A,Malfertheiner P

更新日期：2009-06-01 00:00:00

abstract：:The C-terminus of the transcription factor p53 seems to play an important role by controlling the specific DNA-binding activity, which is directly associated with sensing damaged DNA. Another region located in the N-terminus of the protein has also been shown to regulate the DNA-binding activity of the protein. This a...

journal_title：Peptides

authors： Portefaix JM,Rio MD,Granier C,Roquet F,Pau B,Navarro-Teulon I

更新日期：2003-03-01 00:00:00

abstract：:The purpose of this study was to examine the resting and exercise response patterns of plasma Peptide F immunoreactivity (ir) to altitude exposure (4300 m) and caffeine ingestion (4 mg.kg b.w.-1). Nine healthy male subjects performed exercise tests to exhaustion (80-85% VO2max) at sea level (50 m), during an acute alt...

journal_title：Peptides

authors： Kraemer WJ,Rock PB,Fulco CS,Gordon SE,Bonner JP,Cruthirds CD,Marchitelli LJ,Trad L,Cymerman A

更新日期：1988-09-01 00:00:00

abstract：:Milk is one of the main source of biologically-active peptides that may function as regulatory substances called food hormones. After passing the gut-blood barrier, the μ-opioid receptor agonist and antagonist peptides may become the new factors influencing various functions of the human organism. The aim of the condu...

journal_title：Peptides

authors： Fiedorowicz E,Jarmołowska B,Iwan M,Kostyra E,Obuchowicz R,Obuchowicz M

更新日期：2011-04-01 00:00:00