Tachykinins may mediate capsaicin-induced, but not vagally induced motility in porcine antrum.

abstract：:As an attempt to approach the pathogenesis of peptic ulcer disease, antral gastrin and somatostatin concentrations were studied in normal subjects, patients with duodenal ulcer and gastric ulcer. In the patients with peptic ulcer, antral somatostatin concentrations were significantly lower than those in normal subject...

journal_title：Peptides

authors： Sumii K,Fukushima T,Hirata K,Matsumoto Y,Sanuki E,Tsumaru S,Sumioka M,Miyoshi A,Miyachi Y

更新日期：1981-01-01 00:00:00

abstract：:In the crayfish Astacus leptodactylus, as in several crustacean species, the crustacean hyperglycemic hormone is present as two isoforms differing by the chirality of the third residue, a phenylalanine. In the present work, isoforms synthesized full length by solid-phase peptide synthesis have been purified, refolded,...

journal_title：Peptides

authors： Lebaupain F,Boscameric M,Pilet E,Soyez D,Kamech N

更新日期：2012-03-01 00:00:00

abstract：:Antimicrobial peptides (AMP) have been widely described in several organisms from different kingdoms. We recently designed and evaluated a synthetic version of an AMP isolated and characterized from Argopecten purpuratus hemocytes. This study describes the generation of a chimaeric gene encoding for Ap-S, the use of t...

journal_title：Peptides

authors： Tapia E,Montes C,Rebufel P,Paradela A,Prieto H,Arenas G

更新日期：2011-09-01 00:00:00

abstract：:N-hydroxysuccinimide (NHS) esters of biotin are reported to react specifically with amino groups of peptides and proteins. However, we have found that these reagents can readily acylate other functional groups in specific peptide sequences under relatively mild conditions. We have extended our inquiry of sequence-depe...

journal_title：Peptides

authors： Miller BT,Collins TJ,Rogers ME,Kurosky A

更新日期：1997-01-01 00:00:00

abstract：:Brain-derived neurotrophic factor-like neuropeptide is produced in the brain of the silk moth, Bombyx mori. Immunocytochemical studies of brain and retrocerebral complex of larvae, prepupae, pupae and adults showed that four pairs of median neurosecretory cells and six pairs of lateral neurosecretory cells which had d...

journal_title：Peptides

authors： Park CW,Kim JH,Kim KM,Hwang JS,Kang SW,Kang HS,Cho BP,Yu CH,Kim HR,Lee BH

更新日期：2004-11-01 00:00:00

abstract：:This review is part of a special issue dedicated to Opioid addiction, and examines the influential role of opioid peptides, opioid receptors and opiate drugs in mediating food intake and body weight control in rodents. This review postulates that opioid mediation of food intake was an example of "positive addictive" p...

journal_title：Peptides

authors： Bodnar RJ

更新日期：2019-06-01 00:00:00

abstract：:Endogenous hemorphins, derived from degradation of the beta-chain of hemoglobin, lower arterial blood pressure and exert an antinociceptive action in experimental models of nociception. Hemopressin, derived from the alpha-chain of hemoglobin, also decreases blood pressure, but its effects on pain have not been studied...

journal_title：Peptides

authors： Dale CS,Pagano Rde L,Rioli V,Hyslop S,Giorgi R,Ferro ES

更新日期：2005-03-01 00:00:00

abstract：:Vestibular compensation is a process of CNS plasticity that is correlated to a return of resting activity in medial vestibular nucleus (MVN) neurons ipsilateral to a peripheral vestibular deafferentation. Systemic administration of melanocortin peptides accelerates the compensation process; the ACTH/MSH(4-9) analogue,...

journal_title：Peptides

authors： Gilchrist DP,Darlington CL,Smith PF

更新日期：1996-01-01 00:00:00

abstract：:Apelin, a newly identified bioactive adipokine, has been found to play important roles in multiple diseases, including diabetes, hypertension and cardiovascular diseases with unclear molecular mechanisms. The present study aimed to investigate the effects of apelin on endoplasmic reticulum (ER) stress in the pancreas ...

journal_title：Peptides

authors： Chen H,Zheng C,Zhang X,Li J,Li J,Zheng L,Huang K

更新日期：2011-08-01 00:00:00

abstract：:Four potent angiotensin converting enzyme (ACE) inhibitory peptides, IY, RIY, VW and VWIS, were isolated from subtilisin digest of rapeseed protein. Among them RIY and VWIS are new peptides with IC(50) 28 and 30 microM, respectively. All isolated peptides lowered blood pressure of spontaneously hypertensive rats (SHR)...

journal_title：Peptides

authors： Marczak ED,Usui H,Fujita H,Yang Y,Yokoo M,Lipkowski AW,Yoshikawa M

更新日期：2003-06-01 00:00:00

abstract：:Unilateral intracerebroventricular (ICV) injections of a high dose of CCK7 have been reported to elicit barrel rotations accompanied by contralateral postural asymmetry; there was no spontaneous locomotor activity other than barrel rolling. The aim of the present study was to investigate the effects of lower doses of ...

journal_title：Peptides

authors： Morency MA,Ross GM,Hesketh D,Mishra RK

更新日期：1987-11-01 00:00:00

abstract：:In this work, we characterized the active site in the alpha-melanotropin hormone (alpha-MSH) sequence responsible for the enhancement of cAMP production in incubated striatal slices by using different alpha-MSH fragments. We also analyzed the effects of the co-incubation of the SCH23390, a dopaminergic D(1) antagonist...

journal_title：Peptides

authors： Cecilia Cremer M,Silvina Sanchez M,Ester Celis M

更新日期：2000-06-01 00:00:00

abstract：:Humanin (HN) and HN-derivatives are a family of peptides first reported in the last decade with potent in vitro and in vivo neuroprotective activity, which is mediated through a not completely elucidated mechanism. Recently, our group has evaluated the effect of various HN-derivatives on the 3-quinuclidinyl benzilate ...

journal_title：Peptides

authors： Evangelou A,Zikos C,Benaki D,Pelecanou M,Bouziotis P,Papadopoulos M,Borovickova L,Vesela I,Elbert T,Kunesová G,Pirmettis I,Paravatou-Petsotas M,Slaninová J,Livaniou E

更新日期：2009-12-01 00:00:00

abstract：:Prader-Willi syndrome is characterized by dramatic hyperphagia and morbid obesity, and is associated with a deficiency in basal and meal-stimulated serum pancreatic polypeptide (PP) levels. Intravenous infusions of pancreatic polypeptide (90 min, 50 pmol/kg/h) restored normal serum PP levels, and a regimen of morning ...

journal_title：Peptides

authors： Berntson GG,Zipf WB,O'Dorisio TM,Hoffman JA,Chance RE

更新日期：1993-05-01 00:00:00

abstract：:The leucosulfakinins (LSKs), isolated from head extracts of the cockroach Leucophaea maderae, are sulfated neuropeptides with homology to gastrin and cholecystokinin. The undecapeptide LSK and decapeptide LSK-II stimulate contractions of the isolated cockroach hindgut. Several structural aspects of the two gastrin/CCK...

journal_title：Peptides

authors： Nachman RJ,Holman GM,Haddon WF

更新日期：1988-01-01 00:00:00

abstract：:Studies involving altered energy balance states in rodents have demonstrated that hypothalamic neuropeptide Y (NPY) activity is strongly activated in states of negative energy balance, such as periods of dietary restriction or starvation. However, in cancer cachexia, when there is a significant reduction in body weigh...

journal_title：Peptides

authors： King PJ,Widdowson PS,Doods H,Williams G

更新日期：2000-01-01 00:00:00

abstract：:MPF is a tetrapeptide (structure Lys-Lys-Gly-Glu) that elicits a variety of neurotrophic effects in vivo consistent with a role in neuronal regeneration. In support of this role, we now show that MPF stimulates the proliferation of cultured astrocytes and neurite outgrowth from cultures of neocortical cholinergic and ...

journal_title：Peptides

authors： Owen DB,Morley JS,Ensor DM,Allen YS,Miles JB

更新日期：1997-01-01 00:00:00

abstract：:Although the biological effects of adrenomedullin (AM) and PAMP have been reported extensively in animal studies and from in-vitro experiments, relatively little information is available on responses to the hormone administered to man. This review summarizes data from the few studies carried out in man. In healthy vol...

journal_title：Peptides

authors： Nicholls MG,Lainchbury JG,Lewis LK,McGregor DO,Richards AM,Troughton RW,Yandle TG

更新日期：2001-11-01 00:00:00

abstract：:Because plasma levels of protein C (PC) or activated protein C (APC) are altered in certain diseases associated with vascular dysfunction, and APC has therapeutic potential in preventing microvascular coagulation in severe sepsis, potential vascular effects of PC and APC were compared to those of the vasoactive peptid...

journal_title：Peptides

authors： Bhattacharya A,Grinnell BW,Cohen ML

更新日期：2000-08-01 00:00:00

abstract：:Intracerebroventricular injection of NPY inhibits epileptiform seizures and seizure-related "wet dog shakes" (WDS) following electrical stimulation of the dentate gyrus or subiculum. This study examined the effects of NPY on seizures and WDS elicited in hippocampal CA3. Like in the other hippocampal regions, NPY signi...

journal_title：Peptides

authors： Klemp K,Woldbye DP

更新日期：2001-03-01 00:00:00

abstract：:A large body of evidence suggests a relationship between depression and coronary heart disease (CHD). Angiotensin-Ⅱ (Ang-Ⅱ) and angiotensin-(1-7) [Ang-(1-7)] are considered to exert biological effects in both conditions. Here, we aimed to determine the role of Ang-Ⅱ and Ang-(1-7) in the occurrence of comorbid depressi...

journal_title：Peptides

authors： Han W,Wei Z,Dang R,Guo Y,Zhang H,Geng C,Wang C,Feng Q,Jiang P

更新日期：2020-09-01 00:00:00

abstract：:Hymenistatin I (HS-I), a cyclic octapeptide [c-(-Pro-Pro-Tyr-Val-Pro-Leu-Ile-Ile-)], was synthesized by the solid-phase peptide synthesis method and examined for its immunosuppressive activity in the humoral and cellular immune responses. The peptide activity was tested on cell lines producing various cytokines. The r...

journal_title：Peptides

authors： Cebrat M,Wieczorek Z,Siemion IZ

更新日期：1996-01-01 00:00:00

abstract：:This study was designed to investigate the effects of synthetic mouse pancreatic polypeptide (mPP) on feeding and anxiety in mice. The intracerebroventricular (i.c.v.) injection of mPP (0.003-3 nmol) dose-dependently increased food intake. A significant increase was observed 20 min after i.c.v. injection and continued...

journal_title：Peptides

authors： Asakawa A,Inui A,Ueno N,Fujimiya M,Fujino MA,Kasuga M

更新日期：1999-12-01 00:00:00

abstract：:The somatostatin analogs D-Phe-Cys-D-Trp-Lys-Thr-Cys-Thr and the corresponding penicillamine compounds have been prepared and tested for their ability to displace [3H]naloxone and [3H] [D-Ala2, D-Leu5]enkephalin from rat brain receptors. While somatostatin and the cystine containing peptide displayed little or no pref...

journal_title：Peptides

authors： Pelton JT,Gulya K,Hruby VJ,Duckles S,Yamamura HI

更新日期：1985-01-01 00:00:00

abstract：:A short neuropeptide F (sNPF) precursor and a sNPF receptor (sNPFR) were characterized for the mosquito, Anopheles gambiae. The sNPFR was expressed in CHO-K1 cells, and it exhibited high affinity binding, IC(50) approximately 3-5 nM, for specific sNPFs. sNPF1 potently inhibited forskolin-stimulated cAMP production by ...

journal_title：Peptides

authors： Garczynski SF,Crim JW,Brown MR

更新日期：2007-01-01 00:00:00

abstract：:Cholecystokinin COOH-terminal octapeptide (CCK-8) produces a satiating effect in the rat and other animals upon peripheral administration. Although it has been demonstrated that the receptors which mediate this action are located in the periphery and are of the CCK-A subtype, their anatomical location has not been fir...

journal_title：Peptides

authors： Murphy RB,Smith GP,Schneider LH,Gibbs J

更新日期：1992-01-01 00:00:00

abstract：:The ability of acute exercise to stimulate appetite and food intake depends on intensity, duration, and agouti-related protein (AGRP) levels. Fasting, as well as any negative energy balance, has been reported to increase AGRP expression in the arcuate nucleus (ARC) of the hypothalamus and other extra-hypothalamic tiss...

journal_title：Peptides

authors： Ghanbari-Niaki A,Nabatchian S,Hedayati M

更新日期：2007-05-01 00:00:00

abstract：:The striatum is richly innervated by both enkephalinergic and dopaminergic neurons, providing an anatomic framework from which intimate functional interrelationships between these neuronal systems may be postulated. Accordingly, many functional processes within dopamine neurons have been shown to be modulated by opioi...

journal_title：Peptides

authors： George SR,Kertesz M

更新日期：1987-05-01 00:00:00

abstract：:Amylin and the structurally and functionally related peptide calcitonin gene-related peptide (CGRP) have been shown to reduce food intake in rats. The aim of the present study was to compare the anorectic potency of both peptides over a wide dose range when administered into the lateral brain ventricle (ICV). Furtherm...

journal_title：Peptides

authors： Lutz TA,Rossi R,Althaus J,Del Prete E,Scharrer E

更新日期：1998-01-01 00:00:00

abstract：:The effects of intracerebroventricular (ICV) and intravenous injections of bombesin (BBS) on food intake were investigated in turkeys. Adult turkey hens were injected ICV with 50 to 1000 ng of BBS. In addition, the effect of pretreatment with the BBS antagonist [d-Arg1, D-Phe5, D-Trp7,9, Leu11]-substance P was investi...

journal_title：Peptides

authors： Denbow DM

更新日期：1989-03-01 00:00:00