Abstract:
:The role of muscarinic receptor subtype(s) in the control of gastric phase III contractions and motilin release was determined in dogs. Pirenzepine (226 nmol/kg/h) shortened the phase III cycle, causing an early increase in plasma motilin concentrations. Both AF-DX116BS and 4-DAMP inhibited the occurrence of spontaneous and motilin-induced phase III contractions, and 4-DAMP also inhibited the spontaneous increase in plasma motilin concentration. Only 4-DAMP inhibited carbachol-induced motilin release in perifused duodenal mucosal cells. In conclusion, M1 receptors are involved in the indirect inhibition of motilin release. Motilin-induced contractions are mediated mainly by M3 receptors and partly by M2 receptors, and M3 receptors are present in motilin-producing cells.
journal_name
Peptidesjournal_title
Peptidesauthors
Yamada T,Mizumoto A,Satoh M,Haga N,Itoh Zdoi
10.1016/s0196-9781(97)00132-0subject
Has Abstractpub_date
1997-01-01 00:00:00pages
673-80issue
5eissn
0196-9781issn
1873-5169pii
S0196-9781(97)00132-0journal_volume
18pub_type
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