Abstract:
:We have attempted to demonstrate a pancreatic secretory response to intraduodenal amino acids in the anesthetized cat. In four cats stimulated with supramaximal doses of secretin, protein concentrations in pancreatic juice were measured after intraduodenal bolus injection of various amino acids, IV CCK, or electrical stimulation of the vagus nerve. In addition, the duodenum was perfused with phenylalanine (50 mM) for 30 min in two cats, and the vagus nerve stimulated electrically for 15 min in one. In no case did amino acids produce pancreatic protein secretion, whereas CCK and vagal stimulation always did so. We conclude that this insensitivity to amino acids in the cat is a species difference from the dog and man.
journal_name
Peptidesjournal_title
Peptidesauthors
Johnson C,Jeanningros R,Sarles Hdoi
10.1016/0196-9781(82)90040-7subject
Has Abstractpub_date
1982-03-01 00:00:00pages
129-31issue
2eissn
0196-9781issn
1873-5169pii
0196-9781(82)90040-7journal_volume
3pub_type
杂志文章相关文献
PEPTIDES文献大全abstract::Ad lib and intraoral intake tests can separate the effects of drugs on the appetitive and consummatory phases of ingestive behavior. Central angiotensin II increases ad lib intake from water bottles, but its effect on intraoral intake has not been examined. Rats with both lateral intracerebroventricular (i.c.v.) cannu...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(97)00269-6
更新日期:1998-01-01 00:00:00
abstract::Angiotensin(1-7) had a compound effect on blood pressure of pithed Sprague-Dawley rats. The initial phase of the response consisted of an increase in MAP of short duration and independent of injected dose, followed by a decline of arterial pressure to values below baseline. Both the magnitude (range: -4 +/- 1 to -13 +...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(93)90097-z
更新日期:1993-07-01 00:00:00
abstract::Honeybee stings are a severe public health problem. Bee venom contains a series of active components, including enzymes, peptides, and biogenic amines. The local reactions observed after envenoming include a typical inflammatory response and pain. Honeybee venom contains some well-known polycationic peptides, such as ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2014.07.004
更新日期:2014-09-01 00:00:00
abstract::Although renin, the rate-limiting enzyme of the renin-angiotensin system (RAS), was first discovered by Robert Tigerstedt and Bergman more than a century ago, the research on the RAS still remains stronger than ever. The RAS, once considered to be an endocrine system, is now widely recognized as dual (circulating and ...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2011.05.012
更新日期:2011-07-01 00:00:00
abstract::Unilateral intracerebroventricular (ICV) injections of a high dose of CCK7 have been reported to elicit barrel rotations accompanied by contralateral postural asymmetry; there was no spontaneous locomotor activity other than barrel rolling. The aim of the present study was to investigate the effects of lower doses of ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(87)90126-4
更新日期:1987-11-01 00:00:00
abstract::The role of muscarinic receptor subtype(s) in the control of gastric phase III contractions and motilin release was determined in dogs. Pirenzepine (226 nmol/kg/h) shortened the phase III cycle, causing an early increase in plasma motilin concentrations. Both AF-DX116BS and 4-DAMP inhibited the occurrence of spontaneo...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(97)00132-0
更新日期:1997-01-01 00:00:00
abstract::Human Zonulin, related to the Zonula occludens toxin of Vibrio cholerae, regulates intestinal permeability and is induced in inflammatory disorders of the lower GI tract. Gastroesophageal reflux disease (GERD) is associated with an impairment of epithelial barrier function. Here, we studied expression of zonulin in th...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2009.03.017
更新日期:2009-06-01 00:00:00
abstract::Humanin (HN) and HN-derivatives are a family of peptides first reported in the last decade with potent in vitro and in vivo neuroprotective activity, which is mediated through a not completely elucidated mechanism. Recently, our group has evaluated the effect of various HN-derivatives on the 3-quinuclidinyl benzilate ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2009.07.028
更新日期:2009-12-01 00:00:00
abstract::VIP and secretin control the secretory function of the normal pancreas. We analysed their regulatory functions in a human pancreatic cancer cell line: Capan-1. Saturation binding experiments with 125I-VIP showed the existence of one class of binding sites of very high affinity: KD 6.4 +/- 3.0 X 10(-11) M and a low Bma...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(86)90200-7
更新日期:1986-01-01 00:00:00
abstract::We investigated the effect of synthetic antimicrobial decapeptide KSL-W (KKVVFWVKFK) on normal human gingival fibroblast growth, migration, collagen gel contraction, and α-smooth muscle actin protein expression. Results show that in addition to promoting fibroblast adhesion by increasing F-actin production, peptide KS...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2017.05.003
更新日期:2017-07-01 00:00:00
abstract::In this study we investigated the role that dopaminergic pathways play in the miotic effect exerted by neurotensin after intracameral administration. Neurotensin was injected into the anterior chamber (AC) at a dose of 30 micrograms to 4 groups of albino rabbits which had previously undergone the following treatment: ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(90)90165-2
更新日期:1990-11-01 00:00:00
abstract::The endangered anuran species, Odorrana ishikawae, is endemic to only two small Japanese Islands, Amami and Okinawa. To assess the innate immune system in this frog, we investigated antimicrobial peptides in the skin using artificially bred animals. Nine novel antimicrobial peptides containing the C-terminal cyclic he...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2010.12.013
更新日期:2011-04-01 00:00:00
abstract::The temporins are a family of hydrophobic, C-terminally alpha-amidated antimicrobial peptides that are synthesized in the skins of a wide range of species of frogs belonging to the genus Rana. In the present study, we investigated using RT-PCR the expression of preprotemporin mRNAs in extradermal tissues of Tago's bro...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2006.03.023
更新日期:2006-09-01 00:00:00
abstract::Solubilization of rat synaptic membranes by Triton X-100 followed by DEAE-cellulose chromatography allowed the separation of a phosphoramidon-sensitive endopeptidase that cleaved CCK-8. This enzymatic activity revealed similar if not identical to "enkephalinase A." A major cleavage point, at the Trp30-Met31 bond, and ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(84)90098-6
更新日期:1984-05-01 00:00:00
abstract::We examined the mechanism through which leptin increases Na(+), K(+)-ATPase activity in the rat kidney. Leptin was infused under anaesthesia into the abdominal aorta proximally to the renal arteries and then Na(+), K(+)-ATPase activity was measured in the renal cortex and medulla. Leptin (1mug/kgmin) increased Na(+), ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2006.08.010
更新日期:2006-12-01 00:00:00
abstract::Obstructive jaundice (OJ) increases the risk of liver injury and sepsis, leading to increased mortality. Cholestatic liver injury is associated with a downregulation of hepcidin expression levels. In fact, hepcidin has an important antimicrobial effect, especially against Escherichia coli. It is unknown whether supple...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.03.032
更新日期:2012-06-01 00:00:00
abstract::Capsaicin-sensitive sensory nerves participate in the regulation of cardiovascular functions both in the normal state and the pathophysiology of hypertension through the actions of potent vasodilator neuropeptides, including calcitonin gene-related peptide (CGRP). CGRP, a very potent vasodilator, is the predominant ne...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2005.02.002
更新日期:2005-09-01 00:00:00
abstract::Osmotic stress stimulates the release of the avian hypothalamic neuropeptide arginine vasotocin (AVT) into the peripheral circulation. We conducted the present study to investigate the effects of salt-loading on AVT secretion and AVT gene expression in specific hypothalamic nuclei in chickens. White Leghorn chickens w...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(97)00190-3
更新日期:1997-01-01 00:00:00
abstract::Brazilian freshwater stingrays, Potamotrygon gr. orbigyni, are relatively common in the middle-western regions of Brazil, where they are considered an important public health threat. In order to identify some of their naturally occurring toxin peptides available in very low amounts, we combine analytical protocols suc...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2009.08.004
更新日期:2009-12-01 00:00:00
abstract::Apamin is a neurotoxic octadecapeptide from bee venom, which has been shown to inhibit the non-adrenergic, non-cholinergic inhibitory innervation of the smooth muscle of the gut. Since vasoactive intestinal polypeptide (VIP) has been proposed as a possible inhibitory neurotransmitter, the effect of apamin on the recep...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(83)90102-x
更新日期:1983-03-01 00:00:00
abstract::By using specific antibodies and radioimmunological and immunohistochemical methods, we here show that neuropeptide FF (NPFF) occurs in cervical and lumbar dorsal root ganglia cells. Levels in the ganglia were low because they were detectable only after colchicine treatment or after unilateral dorsal rhizotomy. Simila...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(99)00039-x
更新日期:1999-01-01 00:00:00
abstract::Peptides of the short neuropeptide F (sNPF) family have been shown to modulate feeding behavior in a wide variety of insect species. While these peptides stimulate feeding and food-searching behavior in Drosophila melanogaster and Apis mellifera, an opposite effect has recently been demonstrated in the desert locust, ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2013.09.018
更新日期:2014-03-01 00:00:00
abstract::Ureases (EC 3.5.1.5) are metalloenzymes that hydrolyze urea into ammonia and CO(2). These proteins have insecticidal and fungicidal effects not related to their enzymatic activity. The insecticidal activity of urease is mostly dependent on the release of internal peptides after hydrolysis by insect digestive cathepsin...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.08.010
更新日期:2012-11-01 00:00:00
abstract::We examined the effect of adjuvant arthritis on the content of immunoreactive calcitonin gene-related peptide (iCGRP) in the dorsal root ganglia at L4-L6 levels and the spinal cord at a lumbar level in rats. Arthritis was induced by inoculating adjuvant into both hind-paws twice at a 10 day interval. In the arthritic ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(89)90057-0
更新日期:1989-03-01 00:00:00
abstract::Using a one-bottle taste aversion conditioning paradigm, sulfated cholecystokinin(26-33) (CCK-8) has again been shown to induce taste aversion conditioning in rats. Even though the effective doses of CCK-8 are relatively high, they do not induce as strong an aversion as has been demonstrated with LiCl. This pharmacody...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(95)00001-z
更新日期:1995-01-01 00:00:00
abstract::Opiate alkaloids and opioid peptides have been shown to suppress plasma LH and FSH levels via a naloxone sensitive mechanism in several species including man. Three subtypes of opiate receptors have been characterized: mu, delta and kappa. The present study was designed to investigate their role in gonadotropin releas...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(83)90012-8
更新日期:1983-09-01 00:00:00
abstract::A novel protein expressed by entero-endocrine cells of the mouse stomach was named prepromotilin Related Peptide (ppMTLRP) since it shares sequence similarities with the prepromotilin (Tomasetto et al.). The mouse ppMTLRP was found identical to the rat precursor of ghrelin (ppghrelin), an endogenous ligand specific fo...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(01)00557-5
更新日期:2001-12-01 00:00:00
abstract::Locust abdominal ganglia are shown to colocalize Locusta-diuretic peptide-, leucokinin I-, and lysine vasopressin-like immunoreactivity in posterior lateral neurosecretory cells. Extracts of abdominal ganglia were partially purified by RP-HPLC then dot immunoassay screened with the same antisera used for immunocytoche...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(94)00158-3
更新日期:1995-01-01 00:00:00
abstract::Intestinal levels of immunoreactive neurotensin (iNT) and neuromedin N (iNMN), as well as mRNA for the NT/NMN precursor, were elevated during the suckling period in rats. While transient expression of NT/NMN was observed at 1-5 days of age in the proximal small intestine and colon, NT/NMN levels in the ileum increased...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(93)90161-9
更新日期:1993-11-01 00:00:00
abstract::Bilateral electrolytic lesions of caudate nucleus were observed to potentiate the cataleptic response, and to prevent the muscular rigidity produced by intracerebroventricular injection or infusion of dermorphin. These results suggest that caudate nucleus plays an inhibitory role in controlling the cataleptic response...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(85)90368-7
更新日期:1985-01-01 00:00:00