Metabolic fate of nociceptin/orphanin FQ in the rat spinal cord and biological activity of its released fragment.

abstract：:The effect of arginine vasopressin (AVP) on rat antinociception was investigated. Intraventricular injection of 50 or 100 ng AVP dose-dependently increased the pain threshold; in contrast, intraventricular injection of 10 microl anti-AVP serum decreased the pain threshold; both intrathecal injection of 200 ng AVP or 1...

journal_title：Peptides

authors： Yang J,Song CY,Liu WY,Lin BC

更新日期：2006-12-01 00:00:00

abstract：:Bacillus thuringiensis Cry toxins recognizes their target cells in part by the binding to glycosyl-phosphatidyl-inositol (GPI) anchored proteins such as aminopeptidase-N (APN) or alkaline phosphatases (ALP). Treatment of Tenebrio molitor brush border membrane vesicles (BBMV) with phospholipase C that cleaves out GPI-a...

journal_title：Peptides

authors： Zúñiga-Navarrete F,Gómez I,Peña G,Bravo A,Soberón M

更新日期：2013-03-01 00:00:00

abstract：:We show here that crotamine, a polypeptide from the South American rattlesnake venom with cell penetrating and selective anti-fungal and anti-tumoral properties, presents a potent anti-plasmodial activity in culture. Crotamine inhibits the development of the Plasmodium falciparum parasites in a dose-dependent manner [...

journal_title：Peptides

authors： El Chamy Maluf S,Dal Mas C,Oliveira EB,Melo PM,Carmona AK,Gazarini ML,Hayashi MA

更新日期：2016-04-01 00:00:00

abstract：:Mate attraction in Aplysia involves the long-distance water-borne protein pheromones attractin, enticin, and temptin which are released during egg-laying. Other water-borne pheromones are predicted to act in concert with attractin, enticin, and temptin, but their identities were unknown. We recently identified a highl...

journal_title：Peptides

authors： Cummins SF,Nichols AE,Warso CJ,Nagle GT

更新日期：2005-03-01 00:00:00

abstract：:Trefoil factor family (TFF) 1, 2, and 3 is a mucin-associated protein involved in the maintenance of mucosal barrier and restitution of lining epithelial cells. In this study, the expression of TFF1, 2, and 3 and MUC mucins were examined immunohistochemically in hepatolithiasis and control livers. The expression of TF...

journal_title：Peptides

authors： Sasaki M,Ikeda H,Ohira S,Ishikawa A,Nakanuma Y

更新日期：2004-05-01 00:00:00

abstract：:The amidated beta-casomorphin morphiceptin Tyr-Pro-Phe-Pro-NH2 is an opioid peptide isolated from bovine milk beta-casein digests whose physiological significance remains unclear. Opiates are known to modify intestinal electrolyte transport by acting on receptors located on the serosal side of the intestine. The aim o...

journal_title：Peptides

authors： Mahe S,Tome D,Dumontier AM,Desjeux JF

更新日期：1989-01-01 00:00:00

abstract：:Dispersed cells from chicken brain and liver were found to possess cell surface binding sites for 125I-neurotensin (125I-NT). Scatchard analyses indicated the presence of high affinity (K4, 25-80 pM) and low affinity (Kd, 250-450 pM) components in adult tissues. Binding capacity was reduced 25-40% by incubation with p...

journal_title：Peptides

authors： Mitra SP,Carraway RE

更新日期：1997-01-01 00:00:00

abstract：:The C-terminus of the transcription factor p53 seems to play an important role by controlling the specific DNA-binding activity, which is directly associated with sensing damaged DNA. Another region located in the N-terminus of the protein has also been shown to regulate the DNA-binding activity of the protein. This a...

journal_title：Peptides

authors： Portefaix JM,Rio MD,Granier C,Roquet F,Pau B,Navarro-Teulon I

更新日期：2003-03-01 00:00:00

abstract：:Heat-stable enterotoxin b (STb) of Escherichia coli is a 48-amino acid basic, disulfide-bonded peptide that causes intestinal secretion in experimental animal models. Recent evidence suggests that the in vivo mechanism of STb action involves release of 5-hydroxytryptamine (5-HT) and production of prostaglandin E2 (PGE...

journal_title：Peptides

authors： Harville BA,Dreyfus LA

更新日期：1996-01-01 00:00:00

abstract：:Insulin has been detected by ELISA in the vitreous of the normal and streptozotocin-diabetic rat at levels for both about 1% of those in serum. 131I-labeled insulin, administered to conscious rats via an indwelling cannula in the right atrium, was found to cross the blood-ocular barrier into the vitreous. Autoradiogra...

journal_title：Peptides

authors： Shires TK,Braddock KJ,Pulido JS

更新日期：1992-07-01 00:00:00

abstract：:The roles of thyrotropin releasing hormone (TRH) and oxytocin as central regulators of gastric motility were investigated. Picomolar (4 picomoles) quantities of TRH injected into the dorsal motor nucleus of the vagus (DMN) elicited a significant increase in gastric motility while the same quantity of oxytocin elicited...

journal_title：Peptides

authors： Rogers RC,Hermann GE

更新日期：1987-05-01 00:00:00

abstract：:In vitro pepsin treatment of plasma proteins generates biologically active peptides such as enkephalin-related peptides. These peptides were characterized using chromatographic techniques along with a radioimmunoassay procedure involving the use of Leu-enkephalin and Met-enkephalin antisera. Serum albumin is the only ...

journal_title：Peptides

authors： Garreau I,Pejoan C,Bressollier P,Verneuil B,Cucumel K,Cupo A

更新日期：1994-01-01 00:00:00

abstract：:Ghrelin, a novel gut hormone, has been shown to exert protective effects on cardiac dysfunction and remodeling. However, the underlying mechanisms of its protective effects remain unclear. Here, we investigated the effects of ghrelin on cardiac hypertrophy and explored the mechanisms involved. Ghrelin (30 μg.kg-1. day...

journal_title：Peptides

authors： Lu W,Cai H,Chen Y,Liao X,Zhang L,Ma T,Sun H,Qi Y

更新日期：2020-11-13 00:00:00

abstract：:Marine snails of the genus Conus (∼500 species) are tropical predators that produce venoms for capturing prey, defense and competitive interactions. These venoms contain 50-200 different peptides ("conotoxins") that generally comprise 7-40 amino acid residues (including 0-5 disulfide bridges), and that frequently cont...

journal_title：Peptides

authors： Zamora-Bustillos R,Rivera-Reyes R,Aguilar MB,Michel-Morfín E,Landa-Jaime V,Falcón A,Heimer EP

更新日期：2014-03-01 00:00:00

abstract：:Receptor binding analysis was performed in the renal medulla from 2-month-old rats, an extrapituitary tissue containing the highest level of GHRH receptor mRNA. At 4 degrees C, in the presence of a cocktail of protease inhibitors, binding of [125I-Tyr(10)]hGHRH (1-44)NH(2) to medullary homogenates was specific, time-d...

journal_title：Peptides

authors： Boulanger L,Girard N,Strecko J,Gaudreau P

更新日期：2002-06-01 00:00:00

abstract：:Histidyl-proline diketopiperazine (cyclo(His-Pro), a metabolite of the neuropeptide thyrotropin releasing hormone, has been shown to possess intrinsic biological activities. The binding of this peptide to various tissue particulate preparations was investigated. While the peptide showed no apparent binding to particul...

journal_title：Peptides

authors： Bataini F,Koch Y,Takahara Y,Peterkofsky A

更新日期：1983-01-01 00:00:00

abstract：:On attempts to identify toxins showing original profile of activity among K+ channels, we purified Kbot1, a scorpion toxin that blocks Kv1 and SK potassium channels. With 28 amino-acid residues, Kbot1 is the shortest toxin sequenced in Buthus occitanus scorpion. It is linked by three disulfide bridges and its primary ...

journal_title：Peptides

authors： Mahjoubi-Boubaker B,Crest M,Khalifa RB,El Ayeb M,Kharrat R

更新日期：2004-04-01 00:00:00

abstract：:We have studied the in vitro effect of VIP and histamine on ultrastructure of the parietal cells in isolated guinea pig fundic glands. The morphological changes induced by histamine in the parietal cells can be compared to those observed after histamine stimulation in vivo or in vitro on gastric mucosa preparations. I...

journal_title：Peptides

authors： Anteunis A,Gespach C,Astesano A,Emami S,Robineaux R,Rosselin G

更新日期：1984-03-01 00:00:00

abstract：:The distribution of neurokinin B (NKB) was determined by immunocytochemistry with antisera directed toward its amino terminus. Immunoreactive perikarya were detected in the main and accessory olfactory bulbs, cortical regions, the olfactory tubercle, the bed nucleus of the stria terminalis, the diagonal band of Broca,...

journal_title：Peptides

authors： Merchenthaler I,Maderdrut JL,O'Harte F,Conlon JM

更新日期：1992-07-01 00:00:00

abstract：:The involvement of the hypothalamic beta-endorphinergic system in behavioral processes has previously been studied in adult rats. In the present report, we studied the effects of undernutrition and of inhibitory avoidance training on the hypothalamic beta-endorphin-like immunoreactivity of 21-day-old and adult rats. R...

journal_title：Peptides

authors： Vendite D,Rocha JB,Souza DO

更新日期：1988-07-01 00:00:00

abstract：:Pheromone biosynthesis activating neuropeptide (PBAN) produced in the subesophageal ganglion stimulates pheromone production in the pheromone gland. A cDNA isolated from female adult heads of the diamondback moth (Plutella xylostella (L.)) encodes 193 amino acids including PBAN, designated as Plx-PBAN, and four other ...

journal_title：Peptides

authors： Lee DW,Boo KS

更新日期：2005-12-01 00:00:00

abstract：:TRH and PS-24 (a TRH peptidase resistant analogue) induce different effects on body temperature and motor activity in rats kept at 4 degrees C. PS-24 induced hypothermia, but TRH did not. PS-24 induced hypermotility, while TRH induced slight hypomotility. The thermal effect of TRH in hypophysectomized rats was similar...

journal_title：Peptides

authors： Yehuda S,Youdim MB

更新日期：1981-07-01 00:00:00

abstract：:Melanin-concentrating hormone (MCH) has attracted considerable attention because of its effects on food intake and body weight and the MCH receptor (MCHR1) remains one of the viable targets for obesity therapy. This review summarizes the literature examining the effects of MCH on body weight, food intake and energy ex...

journal_title：Peptides

authors： Pissios P

更新日期：2009-11-01 00:00:00

abstract：:The definitive function of pancreatic polypeptide in mammalian physiology remains unknown. The identification of specific PP target tissues should be helpful to further investigations into the possible regulatory actions of this peptide. An in vivo radioreceptor assay was used in the rat to locate potential binding si...

journal_title：Peptides

authors： Shetzline MA,Zipf WB,Nishikawara MT

更新日期：1998-01-01 00:00:00

abstract：:The geniculohypothalamic tract (GHT) is a projection from the intergeniculate leaflet to the suprachiasmatic nucleus (SCN). The GHT exhibits neuropeptide Y (NPY) immunoreactivity and appears to communicate photic information to the SCN. Microinjection of NPY into the SCN has been found to phase shift circadian rhythms...

journal_title：Peptides

authors： Huhman KL,Albers HE

更新日期：1994-01-01 00:00:00

abstract：:An immunohistochemical mapping study in the brain and upper spinal cord of the turtle Testudo hermanni Gmelin revealed a wide distribution of somatostatin perikarya and fibres. Within the telencephalon, somatostatin perikarya are present in the anterior olfactory nucleus, in the medial, dorsomedial and dorsal cortex, ...

journal_title：Peptides

authors： Weindl A,Triepel J,Kuchling G

更新日期：1984-01-01 00:00:00

abstract：:The brain and the retrocerebral complex of the locust, Locusta migratoria, were examined for the presence of FMRFamide-related peptides (FaRPs) using an RIA specific for -RFamide. RP-HPLC of these extracts using both C18 and phenyl columns revealed the presence of several FaRPs eluting at different percentages of acet...

journal_title：Peptides

authors： Peeff NM,Orchard I,Lange AB

更新日期：1994-01-01 00:00:00

abstract：:We sought to establish Endothelin (ET-3) role in the central regulation of bile secretion in the rat. The intracerebroventricular (icv) injection of ET-3 evoked a cholestatic or a choleretic effect depending on the administered dose. Lower doses increased bile flow and bicarbonate excretion, whereas higher doses decre...

journal_title：Peptides

authors： Rodríguez MR,Sabbatini ME,Santella G,Dabas P,Villagra A,Vatta MS,Bianciotti LG

更新日期：2005-07-01 00:00:00

abstract：:A new, p -carborane containing analog of tyrosine, 3-[1-hydroxy-1,12-dicarba-closo-dodecaboran (12)-12-yl]alanine, was prepared from protected 3-[1-hydroxy-1,12-dicarba-closo-dodecaboran (12)-12-yl]propionic acid in five steps using Oppolzer's sultam methodology for asymmetric hydroxyamination as the key step. The tyr...

journal_title：Peptides

authors： Ujváry I,Nachman RJ

更新日期：2002-04-01 00:00:00

abstract：:Combined modulation of peptide hormone receptors including, glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and xenin, have established benefits for the treatment of diabetes. The present study has assessed the biological actions and therapeutic efficacy of a novel exendin-4/xenin-8...

journal_title：Peptides

authors： Hasib A,Ng MT,Khan D,Gault VA,Flatt PR,Irwin N

更新日期：2018-02-01 00:00:00