Antimicrobial peptides with atypical structural features from the skin of the Japanese brown frog Rana japonica.

abstract：:Neurotensin (NT) is a tridecapeptide (less than Glu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH). It has been suggested that the naturally occurring neurotensin in (Gln4)-NT and that it can be hydrolysed to (Glu4)-NT during extraction. The aim of the present study was to determine whether the neurotensin found ...

journal_title：Peptides

authors： Theodorsson-Norheim E

更新日期：1983-07-01 00:00:00

abstract：:Pituitary cells from 14-day-old rats were separated by unit gravity velocity sedimentation, and a highly enriched population of gonadotrophs was established in reaggregate cell culture in serum-free and serum albumin-free defined culture media. The medium conditioned by these aggregates was concentrated, ultrafiltrate...

journal_title：Peptides

authors： Tilemans D,Jacobs GF,Andries M,Proost P,Devreese B,Van Damme J,Van Beeumen J,Denef C

更新日期：1994-01-01 00:00:00

abstract：:Neurotensin and somatostatin have both been shown to inhibit gastric acid secretion, but no interaction between these peptides has been demonstrated. To determine whether somatostatin might be a mediator of neurotensin's effect on pentagastrin-stimulated gastric acid secretion, we performed the following three experim...

journal_title：Peptides

authors： Hammer RA,Ochoa A,Fernandez C,Ertan A,Arimura A

更新日期：1992-11-01 00:00:00

abstract：:One major cause for discrepancies in results from animal experimental studies is the use of different animal strains and suppliers. We have previously reported that Wistar rats from five different suppliers display profound differences in ethanol intake and behavior. One of the neurobiological processes that could be ...

journal_title：Peptides

authors： Palm S,Roman E,Nylander I

更新日期：2012-07-01 00:00:00

abstract：:Recent refinements in methodology now permit the study of endogenous peptide hormones in their individual target cells. The investigations reported here deal with the question of whether endogenous ACTH can be detected in its target cells in the highly active adrenal gland of the normally lactating rat. This question ...

journal_title：Peptides

authors： Nolin JM

更新日期：1980-10-01 00:00:00

abstract：:The purpose of this investigation was to determine the influence of long-distance running on the secretion of the gastrointestinal peptide hormones cholecystokinin (CCK) and gastrin. Several known stress hormones, ACTH, cortisol and norepinephrine, were also measured. The hormones were estimated before and after a com...

journal_title：Peptides

authors： Philipp E,Wilckens T,Friess E,Platte P,Pirke KM

更新日期：1992-01-01 00:00:00

abstract：:Antimicrobial peptides produced by multicellular organisms protect against pathogenic microorganisms, whereas such peptides produced by bacteria provide an ecological advantage over competitors. Certain antimicrobial peptides of metazoan origin are also toxic to eukaryotic cells, with preference for a variety of cance...

journal_title：Peptides

authors： Sand SL,Oppegård C,Ohara S,Iijima T,Naderi S,Blomhoff HK,Nissen-Meyer J,Sand O

更新日期：2010-07-01 00:00:00

abstract：:Urocortin is a newly identified member of the CRF neuropeptide family. Urocortin has been found to bind with high affinity to CRF receptors. The present study investigated urocortin and CRF receptor expression in human colonic mucosa. Non-pathologic sections of adult colorectal tissues were obtained from patients with...

journal_title：Peptides

authors： Muramatsu Y,Fukushima K,Iino K,Totsune K,Takahashi K,Suzuki T,Hirasawa G,Takeyama J,Ito M,Nose M,Tashiro A,Hongo M,Oki Y,Nagura H,Sasano H

更新日期：2000-12-01 00:00:00

abstract：:An identical CRF-related diuretic peptide (Musca-DP) was isolated and characterized from whole-body extracts of the house fly, Musca domestica, and stable fly, Stomoxys calcitrans. The peptide stimulates cyclic AMP production in Manduca sexta Malpighian tubules and increases the rate of fluid secretion by isolated Mus...

journal_title：Peptides

authors： Clottens FL,Holman GM,Coast GM,Totty NF,Hayes TK,Kay I,Mallet AI,Wright MS,Chung JS,Truong O

更新日期：1994-01-01 00:00:00

abstract：:In an immunohistochemical study, a specific antiserum raised against [D-Ala2]deltorphin-I (DADTI), a highly selective ligand for delta opioid receptors, was used to demonstrate immunoreactive structures in the rat retina. [D-Ala2]Deltorphin-I immunoreactivity occurred in a subpopulation of the retinal amacrine cells s...

journal_title：Peptides

authors： Abe H,Tooyama I,Renda T,Erspamer V,Kimura H

更新日期：1994-01-01 00:00:00

abstract：:Expression of the two gonadotropin-releasing hormone homologue peptides GnRHI and GnRHII and their receptor GnRHR has been demonstrated in a number of malignancies. In hormone-dependent breast cancer, GnRH analogs are used for therapy in premenopausal women. Gene expression of GnRHI, II and R was studied in breast bio...

journal_title：Peptides

authors： Pazaitou-Panayiotou K,Chemonidou C,Poupi A,Koureta M,Kaprara A,Lambropoulou M,Constantinidis TC,Galaktidou G,Koffa M,Kiziridou A,Kakolyris S,Kolios G,Kortsaris A,Chatzaki E

更新日期：2013-04-01 00:00:00

abstract：:VIP and related fragments were prepared by the solid-phase method. The peptides were assembled on a benzhydrylamine resin and couplings of the Boc-amino acids were carried out by the symmetrical anhydride method. Cleavage was achieved by treatment with liquid HF and purification was accomplished by successive steps of...

journal_title：Peptides

authors： Fournier A,Saunders JK,St-Pierre S

更新日期：1984-03-01 00:00:00

abstract：:Insect flight requires rapid mobilization of energy reserves during flight, which is mediated and regulated by hormonal control via adipokinetic hormones. The structure of the G-protein receptors to which these hormones bind, are crucial in understanding many of the physiological processes in which they play a central...

journal_title：Peptides

authors： Mugumbate G,Jackson GE,van der Spoel D

更新日期：2011-03-01 00:00:00

abstract：:The presence of a putative GRP receptor on rat pancreatic particulate membranes was demonstrated by covalent cross-linking to 125I-gastrin releasing peptide (GRP), which revealed a radioactive band with Mr = 80-90 kDa on reduced SDS-PAGE. Fresh rat pancreatic membranes contained a GRP receptor which was solubilized wi...

journal_title：Peptides

authors： Kane MA,Kelley K,Ross SE,Portanova LB

更新日期：1991-03-01 00:00:00

abstract：:Herein the effect of orexin receptor type-1 antagonist SB-334867 on the development of tolerance to analgesic effects of morphine was studied in rats. To incite tolerance, morphine sulfate was injected intraperitoneally (i.p., 10mg/kg) once a day for 7 days. The tail flick test was used to evaluate antinociceptive eff...

journal_title：Peptides

authors： Ranjbar-Slamloo Y,Azizi H,Fathollahi Y,Semnanian S

更新日期：2012-05-01 00:00:00

abstract：:There have been few reports on the effects of the brain-gut peptide motilin on the central nervous system (CNS). We administered motilin intracerebroventricularly to mice and investigated the effect of motilin on anxiety using an elevated plus-maze. Motilin produced a significant decrease in anxiety with an inverted U...

journal_title：Peptides

authors： Momose K,Inui A,Asakawa A,Ueno N,Nakajima M,Kasuga M

更新日期：1998-01-01 00:00:00

abstract：:Although previous studies have implicated NPY in the etiology of experimental cancer anorexia, the results have been difficult to interpret. Studies have suggested that although NPY level and message were decreased in the dorsomedial hypothalamic area (DMA), they were elevated in the ventromedial hypothalamic area (VM...

journal_title：Peptides

authors： Chance WT,Xiao C,Dayal R,Sheriff S

更新日期：2007-02-01 00:00:00

abstract：:Neuropeptide FF (NPFF) has certain antiopiate actions and may play a role in opiate tolerance and dependence. Third ventricle injection of 10 micrograms NPFF induces a quasimorphine abstinence syndrome in opiate-naive rats. Nitric oxide synthesis may also contribute to opiate tolerance and dependence. The present stud...

journal_title：Peptides

authors： Malin DH,Lake JR,Jones JA,Morel J,Moon WD,Corbit BP,Smith DA,Claunch AE,Kacher D,Stevens PA,Webb SL

更新日期：1996-01-01 00:00:00

abstract：:Intravenous (IV) infusions of neurotensin (NT) in anesthetized guinea pigs elicited dose-dependent pressor effects and tachycardia. Both effects were significantly reduced or abolished in guinea pigs given a chronic treatment with the neurotoxin capsaicin. In guinea pig isolated atria NT evoked a positive inotropic an...

journal_title：Peptides

authors： Bachelard H,St-Pierre S,Rioux F

更新日期：1987-11-01 00:00:00

abstract：:Binding sites in the rat forebrain were characterized using (125I-Tyr4)bombesin as a receptor probe. Pharmacology experiments indicate that gastrin releasing peptide (GRP) and the GRP fragments GRP as well as Ac-GRP inhibited radiolabeled (Tyr4)bombesin binding with high affinity. Biochemistry experiments indicated th...

journal_title：Peptides

authors： Wolf SS,Moody TW

更新日期：1985-01-01 00:00:00

abstract：:We compared the in vitro and in vivo biological activities of PG-KII (pGlu-Pro-Asn-Pro-Asp-Glu-Phe-Val-Gly-Leu-Met-NH2), a new peptide belonging to the tachykinin family, related to kassinin, isolated and sequenced from extracts of the skin of the Australian myobatrachid frog Pseudophryne güntheri, with those of the w...

journal_title：Peptides

authors： Improta G,Broccardo M,Severini C,Erspamer V

更新日期：1996-01-01 00:00:00

abstract：:The aim of this study was to investigate peripheral and central roles of corticotropin-releasing factor (CRF) in endocrinological and behavioral changes. Plasma adrenocorticotropin (ACTH) concentration was measured as an activity of hypothalamic-pituitary-adrenal (HPA) axis. As behavioral changes, locomotion and anxie...

journal_title：Peptides

authors： Tanaka M,Tomimatsu Y,Sakimura K,Ootani Y,Sako Y,Kojima T,Aso K,Yano T,Hirai K

更新日期：2017-09-01 00:00:00

abstract：:A novel antimicrobial peptide named odorranain-NR was identified from skin secretions of the diskless odorous frog, Odorrana grahami. It is composed of 23 amino acids with an amino acid sequence of GLLSGILGAGKHIVCGLTGCAKA. Odorranain-NR was classified into a novel family of antimicrobial peptide although it shared sim...

journal_title：Peptides

authors： Che Q,Zhou Y,Yang H,Li J,Xu X,Lai R

更新日期：2008-04-01 00:00:00

abstract：:Two food-derived ACE inhibitory peptides, Ile-Pro-Pro (IPP) and Leu-Lys-Pro (LKP), may have potential as alternative treatments for treatment of mild- or pre-hypertension. Lack of stability to secretory and intracellular peptidases and poor permeability across intestinal epithelia are typical limiting factors of oral ...

journal_title：Peptides

authors： Gleeson JP,Heade J,Ryan SM,Brayden DJ

更新日期：2015-09-01 00:00:00

abstract：:The effects of arginine vasotocin (AVT), 4-6 ng/kg, on renal function and plasma prolactin (PRL) were determined in conscious American foxhounds undergoing a water diuresis. Intravenous AVT produced an antidiuresis, kaliuresis and inconsistent natriuresis, independently of changes in GFR, blood pressure, heart rate an...

journal_title：Peptides

authors： Gilmore JP,Wesley CR,Huffman L,Nemeh MN

更新日期：1982-11-01 00:00:00

abstract：:alpha-MSH immunoreactive peptides were fractionated and characterized in rat and human brain and rat pituitary by reversed phase high pressure liquid chromatographic techniques. alpha-MSH and deacetylated alpha-MSH were two major naturally existing peptides in both brain and pituitary gland. Subsequent experiments exa...

journal_title：Peptides

authors： O'Donohue TL,Handelmann GE,Chaconas T,Miller RL,Jacobowitz DM

更新日期：1981-10-01 00:00:00

abstract：:Tight junctions (TJ) control paracellular permeability and apical-basolateral polarity of epithelial cells. Dysregulated permeability is associated with pathological conditions, such as celiac disease and inflammatory bowel disease. TJ formation is dependent on E-cadherin-mediated cell-cell adhesion and actin rearrang...

journal_title：Peptides

authors： Gopalakrishnan S,Tripathi A,Tamiz AP,Alkan SS,Pandey NB

更新日期：2012-05-01 00:00:00

abstract：:Cocaine- and amphetamine regulated transcript (CART) is a recently discovered anorexigenic peptide, widely expressed in the central nervous system. Included among presumed hypothalamic mediated functions of CART are inhibition of food intake, stimulation of energy expenditure and regulation of hypothalamic-pituitary a...

journal_title：Peptides

authors： Fekete C,Lechan RM

更新日期：2006-08-01 00:00:00

abstract：:The elevated T-maze was combined with a free exploration protocol, which, in contrast to the conventional procedure, dispenses with handling of the animals during the experimental sessions. This allows measurement of fear indexes derived from the elevated plus-maze as well as assessment of acquisition of open arm avoi...

journal_title：Peptides

authors： Echeverry MB,Hasenöhrl RU,Huston JP,Tomaz C

更新日期：2001-07-01 00:00:00

abstract：:The effects of atrial natriuretic factor (ANF) on [3H]norepinephrine ([3H]NE) release evoked by a sodium-free medium (SFM) were studied. Experiments were performed in rat adrenal medulla slices incubated in vitro. Results showed that [3H]NE release evoked by the omission of Na+ was decreased by 10 nM ANF. In addition,...

journal_title：Peptides

authors： Vatta MS,Papouchado ML,Bianciotti LG,Fernandez BE

更新日期：1994-01-01 00:00:00