PACAP, VIP and their receptors in the metazoa: insights about the origin and evolution of the ligand-receptor pair.

abstract：:Effects of Met-enkephalin (Met-ENK) and opioid antagonists on H2O2 release by peritoneal macrophages from DA and AO rats were investigated. Met-ENK increased and decreased H2O2 production by macrophages of DA and AO rats, respectively. These effects were antagonized by low, but not high, concentrations of naloxone and...

journal_title：Peptides

authors： Radulović J,Dimitrijević M,Laban O,Stanojević S,Vasiljević T,Kovacević-Jovanović V,Marković BM

更新日期：1995-01-01 00:00:00

abstract：:Quantitative receptor autoradiography using Bolton-Hunter iodinated substance P (SP) was used to localize specific sites in the rat hypothalamus. The amount of SP and neurokinin A (NkA) in extracts from discrete areas of the hypothalamus was measured using specific radioimmunoassays. A high density of SP binding sites...

journal_title：Peptides

authors： Larsen PJ,Jessop DS,Chowdrey HS,Mikkelsen JD,Lightman SL

更新日期：1992-07-01 00:00:00

abstract：:This study sought to determine the serum levels of chemerin in gastric cancer patients and healthy subjects and to investigate the biological effect of chemerin on gastric cancer cells. Serum chemerin level of 36 gastric cancer patients and 40 healthy subjects was measured by enzyme-linked immunosorbent assay. AGS and...

journal_title：Peptides

authors： Wang C,Wu WK,Liu X,To KF,Chen GG,Yu J,Ng EK

更新日期：2014-01-01 00:00:00

abstract：:A 20-kDa protein with substantial N-terminal sequence homology to thaumatin-like proteins was isolated from ripe fruits of the emperor banana, Musa basjoo cv. 'emperor banana'. The isolation procedure entailed (NH(4))(2)SO(4) precipitation, ion exchange chromatography on DEAE-cellulose, and affinity chromatography on ...

journal_title：Peptides

authors： Ho VS,Wong JH,Ng TB

更新日期：2007-04-01 00:00:00

abstract：:The melanocortin system plays an important role in energy homeostasis as well as skin pigmentation, steroidogenesis and exocrine gland function. In this study, we examined eight Ac-His-Phe-Arg-Trp-NH(2) tetrapeptides that were modified at the Phe position and pharmacologically characterized their activities at the hum...

journal_title：Peptides

authors： Chen M,Georgeson KE,Harmon CM,Haskell-Luevano C,Yang Y

更新日期：2006-11-01 00:00:00

abstract：:In the present study we used intracerebral microdialysis techniques to examine whether angiotensin II (ANG II) modulates the release of serotonin (5-hydroxytryptamine, 5-HT) in the subfornical organ (SFO) in freely moving rats. Extracellular concentrations of 5-HT and its metabolite 5-hydroxyindoleacetic acid (5-HIAA)...

journal_title：Peptides

authors： Tanaka J,Kariya K,Nomura M

更新日期：2003-06-01 00:00:00

abstract：:Caudodorsal cell hormone-I (CDCH-I), a 36 amino acid peptide synthesized by the caudodorsal cells (CDCs), is one of the major neuropeptides present in the cerebral ganglia of the freshwater snail, Lymnaea stagnalis. This peptide induces ovulation and egg-mass formation, and, in addition, acts on neuronal circuits invo...

journal_title：Peptides

authors： Li KW,Geraerts WP,Joosse J

更新日期：1992-03-01 00:00:00

abstract：:Early-life stress is a key predisposing factor to the development of functional gastrointestinal (GI) disorders. Thus, changes in stress-related molecular substrates which influence colonic function may be important in understanding the pathophysiology of such disorders. Activation of peripheral corticotropin-releasin...

journal_title：Peptides

authors： O'Malley D,Dinan TG,Cryan JF

更新日期：2010-04-01 00:00:00

abstract：:Peptides of the short neuropeptide F (sNPF) family have been shown to modulate feeding behavior in a wide variety of insect species. While these peptides stimulate feeding and food-searching behavior in Drosophila melanogaster and Apis mellifera, an opposite effect has recently been demonstrated in the desert locust, ...

journal_title：Peptides

authors： Dillen S,Verdonck R,Zels S,Van Wielendaele P,Vanden Broeck J

更新日期：2014-03-01 00:00:00

abstract：:Glucagon-like-peptide-1 (GLP-1) is a proglucagon-derived peptide expressed in the intestinal enteroendocrine-L cells and released after meal ingestion. GLP-1 reduces postprandial glycemia not only by its hormonal effects, but also by its inhibitory effects on gastrointestinal motility. Recently, we showed that GLP-1 a...

journal_title：Peptides

authors： Rotondo A,Amato A,Lentini L,Baldassano S,Mulè F

更新日期：2011-01-01 00:00:00

abstract：:We report herein the isolation and characterization of a novel glycine-rich antimicrobial peptide purified from the larvae of Drosophila virilis. A range of chromatographic methods was used for isolation and its antibacterial activity against Bacillus subtilis was employed to screen for the most active fractions. The ...

journal_title：Peptides

authors： Lu J,Chen ZW

更新日期：2010-01-01 00:00:00

abstract：:C-type natriuretic peptide (CNP) significantly increases in chronic heart failure (CHF) patients as a function of clinical severity. Aim of this study was to evaluate in CHF patients the relationship between circulating CNP concentrations and echo-Doppler conventional indices of left ventricular (LV) function as well ...

journal_title：Peptides

authors： Del Ry S,Maltinti M,Cabiati M,Emdin M,Giannessi D,Morales MA

更新日期：2008-01-01 00:00:00

abstract：:Endothelin-1 may contribute to bronchial smooth muscle constriction and airway remodelling in asthma, where bronchial epithelial cells represent an important source of this peptide. We report here that asthmatic bronchial epithelial cells exposed to allergens in vitro induce the differentiation of airway fibroblasts i...

journal_title：Peptides

authors： Sun G,Stacey MA,Bellini A,Marini M,Mattoli S

更新日期：1997-01-01 00:00:00

abstract：:Immunocytochemistry using an antiserum to the C-terminal octapeptide of synenkephalin, proenkephalin(63-70), was performed throughout the rat brain and revealed numerous immunopositive fibers and some cell bodies. The morphology and distribution of synenkephalin immunoreactivity was extremely similar to that of a comm...

journal_title：Peptides

authors： Song DD,Rossier J,Harlan RE

更新日期：1989-11-01 00:00:00

abstract：:CRF injected into the third cerebral ventricle (0.5-2.5 micrograms) caused dose-related reductions in fever induced in rabbits by IV administration of leukocytic pyrogen. Control injections of CRF when the same animals were afebrile did not alter normal body temperature. Intravenous injections of 5 and 20 micrograms C...

journal_title：Peptides

authors： Bernardini GL,Richards DB,Lipton JM

更新日期：1984-01-01 00:00:00

abstract：:Double-labeling immunofluorescence of guinea pig tracheobronchial lymph nodes revealed complete coincidence of SP and CGRP immunoreactivities in perivascular nerves and axons of the medullary lymphatic tissue. Additional dynorphin A or cholecystokinin immunoreactivity was seen only in some of the medullary fibers. Ult...

journal_title：Peptides

authors： Kurkowski R,Kummer W,Heym C

更新日期：1990-01-01 00:00:00

abstract：:The prothoracicotropic hormones (PTTH) are cerebral peptides that control insect postembryonic development by stimulating the prothoracic glands to synthesize ecdysteroids. Using immunoaffinity chromatography and SDS-PAGE, a 25.5 kDa big PTTH has been purified from Manduca sexta. Based upon SDS-PAGE and Western blot a...

journal_title：Peptides

authors： Muehleisen DP,Gray RS,Katahira EJ,Thomas MK,Bollenbacher WE

更新日期：1993-05-01 00:00:00

abstract：:Hypothalamic orexin neurons project to many brain areas, including hindbrain structures such as the nucleus of the solitary tract (NTS) and area postrema (AP), where orexin 1 receptors (OX1Rs) are expressed. Hindbrain administration of orexin-A increases feeding and meal size, and blockade of hindbrain OX1Rs with the ...

journal_title：Peptides

authors： Williams DL,Coiduras II,Parise EM,Maske CB

更新日期：2020-11-01 00:00:00

abstract：:Honeybee stings are a severe public health problem. Bee venom contains a series of active components, including enzymes, peptides, and biogenic amines. The local reactions observed after envenoming include a typical inflammatory response and pain. Honeybee venom contains some well-known polycationic peptides, such as ...

journal_title：Peptides

authors： Mourelle D,Brigatte P,Bringanti LD,De Souza BM,Arcuri HA,Gomes PC,Baptista-Saidemberg NB,Ruggiero Neto J,Palma MS

更新日期：2014-09-01 00:00:00

abstract：:Antimicrobial peptides, molecules produced in many different organisms, have high biocidal activity against several microorganisms. However, several questions about these molecules remain unclear. Therefore, this report details a systematic survey of the literature on the use of antimicrobial peptides against oral pat...

journal_title：Peptides

authors： da Silva BR,de Freitas VA,Nascimento-Neto LG,Carneiro VA,Arruda FV,de Aguiar AS,Cavada BS,Teixeira EH

更新日期：2012-08-01 00:00:00

abstract：:The distribution and chemical properties of compounds with tachykinin-like immunoreactivity (TK-LI) in the spinal cord and brain of lampreys (Lampetra fluviatilis and Ichthyomyzon unicuspis) were investigated by means of immunohistochemistry and various chromatographic methods combined with radioimmunoassay. The distr...

journal_title：Peptides

authors： Van Dongen PA,Theodorsson-Norheim E,Brodin E,Hökfelt T,Grillner S,Peters A,Cuello AC,Forssmann WG,Reinecke M,Singer EA

更新日期：1986-03-01 00:00:00

abstract：:The presence of atrial natriuretic peptide (ANP) binding sites in the thymic cortex, medulla, and splenic white pulp suggests that this peptide may have immunoregulatory activity. We examined the effect of ANP on human natural killer (NK) cell activity. ANP significantly augmented NK cell cytotoxicity after twenty-fou...

journal_title：Peptides

authors： Moss RB,Golightly MG

更新日期：1991-07-01 00:00:00

abstract：:As a novel vasoactive peptide, plasma coupling factor 6 (CF6) was shown to be elevated in patients with diabetes mellitus, yet the mechanism involved is unknown. We studied CF6 protein release and its potential mechanism in human umbilical vein endothelial cells (HUVECs) incubated with high glucose levels. High glucos...

journal_title：Peptides

authors： Li X,Xing S,Zhang L,Xing Q,Yan S,Dai H,You S,Pang Y,Tang C

更新日期：2007-03-01 00:00:00

abstract：:The expression of the relaxin-3 gene, detected as a new member of the insulin superfamily using human genomic databases, is abundantly present in the brain and testis. Intracerebroventricularly (icv) administered relaxin-3 stimulates food intake. Icv administered relaxin (identical to relaxin-2 in humans) affects the ...

journal_title：Peptides

authors： Otsubo H,Onaka T,Suzuki H,Katoh A,Ohbuchi T,Todoroki M,Kobayashi M,Fujihara H,Yokoyama T,Matsumoto T,Ueta Y

更新日期：2010-06-01 00:00:00

abstract：:Irisin was first identified in skeletal muscle cells, but its precise location has not yet been demonstrated, and there is limited information about irisin protein in other human and rat tissues. The present immunohistochemical study was undertaken to screen skeletal muscle and other tissues for irisin immunoreactivit...

journal_title：Peptides

authors： Aydin S,Kuloglu T,Aydin S,Kalayci M,Yilmaz M,Cakmak T,Albayrak S,Gungor S,Colakoglu N,Ozercan IH

更新日期：2014-11-01 00:00:00

abstract：:Melanin-concentrating hormone (MCH) is a hypothalamic peptide that plays a critical role in the regulation of food intake and energy metabolism. In this study, we investigated the potential role of dense hippocampal MCH innervation in the spatially oriented food-seeking component of feeding behavior. Rats were trained...

journal_title：Peptides

authors： Sita LV,Diniz GB,Canteras NS,Xavier GF,Bittencourt JC

更新日期：2016-02-01 00:00:00

abstract：:The geniculohypothalamic tract (GHT) is a projection from the intergeniculate leaflet to the suprachiasmatic nucleus (SCN). The GHT exhibits neuropeptide Y (NPY) immunoreactivity and appears to communicate photic information to the SCN. Microinjection of NPY into the SCN has been found to phase shift circadian rhythms...

journal_title：Peptides

authors： Huhman KL,Albers HE

更新日期：1994-01-01 00:00:00

abstract：:A study was made of the effect of adrenalectomy over different periods of time (6, 15 and 21 days) on exocrine pancreatic secretion in the rat in basal conditions and under stimulation with CCK. It was observed that adrenalectomy does not alter the rate of pancreatic flow but the response capacity to CCK is depressed....

journal_title：Peptides

authors： Manso MA,De Dios I,Garcia AM,Calvo JJ

更新日期：1988-05-01 00:00:00

abstract：:The incretin hormones, glucose dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1), potentiate insulin secretion and are responsible for the majority of insulin secretion that occurs after a meal. They may also, however, have a fundamental role in pancreatic beta cell development and functio...

journal_title：Peptides

authors： Omar B,Ahlkvist L,Yamada Y,Seino Y,Ahrén B

更新日期：2016-05-01 00:00:00

abstract：:An antifungal peptide with a molecular mass of 9412 and an N-terminal sequence exhibiting notable homology to those of lipid transfer proteins was isolated from seeds of the vegetable Brassica campestris. The purification protocol entailed ion exchange chromatography on Q-Sepharose, affinity chromatography on Affi-gel...

journal_title：Peptides

authors： Lin P,Xia L,Ng TB

更新日期：2007-08-01 00:00:00