Characterization of GIP(1-30) and GIP(1-42) as stimulators of proinsulin gene transcription.

abstract：:We measured the concentration of beta-endorphin (beta-End) in plasma, as well as in aqueous humor and crystalline lens removed during cataract surgery. beta-End was detected both in the aqueous humor and in the crystalline lens. The concentration of beta-End in the aqueous humor corresponded to almost the half of the ...

journal_title：Peptides

authors： Bender T,Török I,Barna I,Géher P

更新日期：2001-04-01 00:00:00

abstract：:A sparse to moderate supply of nerve fibers containing neuropeptide Y-like immunoreactivity (NPY-LI), vasoactive intestinal polypeptide (VIP-LI), substance P (SP-LI), and calcitonin gene-related peptide (CGRP-LI) was demonstrated in the walls of human middle meningeal arteries. Comparison with similar studies on human...

journal_title：Peptides

authors： Jansen I,Uddman R,Ekman R,Olesen J,Ottosson A,Edvinsson L

更新日期：1992-05-01 00:00:00

abstract：:Prothymosin alpha (ProTα), a nuclear protein, plays multiple functions including cell survival. Most recently, we demonstrated that the active 30-amino acid peptide sequence/P30 (amino acids 49-78) in ProTα retains its substantial activity in neuroprotection in vitro and in vivo as well as in the inhibition of cerebra...

journal_title：Peptides

authors： Halder SK,Sugimoto J,Matsunaga H,Ueda H

更新日期：2013-05-01 00:00:00

abstract：:Increased plasma levels of neuropeptide Y (NPY)-like immunoreactivity (p-NPY-LI) have been described in hemodialysis (HD) patients. In this investigation the effect of a standard HD on p-NPY-LI, analyzed by radioimmunoassay and reverse-phase high performance liquid chromatography (HPLC), was studied. During dialysis p...

journal_title：Peptides

authors： Hegbrant J,Thysell H,Ekman R

更新日期：1995-01-01 00:00:00

abstract：:In the conscious dog migrating and nonmigrating colonic motor complexes (CMC) were recorded by means of chronically implanted strain gauge force transducers. Intravenous injection of a synthetic enkephalin analogue immediately induced a premature CMC at all three recording sites of the colon. Naloxone inhibited the en...

journal_title：Peptides

authors： Bickel M,Belz U

更新日期：1988-05-01 00:00:00

abstract：:During a systemic search for peptides that possess the C-terminal amide structure, a novel heptapeptide with isoleucine amide was isolated from bovine serum by sequential steps of reversed phase HPLC. Microsequence and amino acid analyses revealed the structure: Asp-Thr-His-Lys-Ser-Glu-Ile-NH2. Since this peptide has ...

journal_title：Peptides

authors： Takamatsu K,Tatemoto K

更新日期：1991-03-01 00:00:00

abstract：:Nervous, endocrine, and immune systems share a large number of regulatory molecules including hormones and neuropeptides. Vasoactive intestinal peptide (VIP) plays an important role in a variety of immunological functions. In the present report, we sorted purified thymocytes of the four major thymic subsets defined by...

journal_title：Peptides

authors： Delgado M,Martínez C,Leceta J,Garrido E,Gomariz RP

更新日期：1996-01-01 00:00:00

abstract：:We examined the effects of tumor necrosis factor (TNF)-alpha on the expression and functionality of adrenomedullin (AM) receptors in cultured human coronary artery smooth muscle cells. Analysis of real-time quantitative polymerase chain reactions showed that these cells abundantly express two AM receptors comprised of...

journal_title：Peptides

authors： Nagoshi Y,Kuwasako K,Cao YN,Imamura T,Kitamura K,Eto T

更新日期：2004-07-01 00:00:00

abstract：:Three separate sets of receptors sensitive to VIP, GIP and pancreatic/entero-glucagons, have been characterized in HGT-1 cells. The order of relative potencies of VIP receptor agonists was VIP greater than rh GRF-43, rh GRF-29 greater than PHI greater than hp GRF-40, secretin. G-37 was about 4 times less potent than G...

journal_title：Peptides

authors： Emami S,Chastre E,Bodéré H,Gespach C,Bataille D,Rosselin G

更新日期：1986-01-01 00:00:00

abstract：:The intestinal enzymatic degradation of the immunomodulating peptides thymotrinan (TP3), thymocartin (TP4), and thymopentin (TP5), three oligopeptides derived from the naturally occurring thymus hormone thymopoietin, was investigated to evaluate their potential for peroral drug delivery. In the presence of brush-borde...

journal_title：Peptides

authors： Heizmann J,Langguth P,Biber A,Oschmann R,Merkle HP,Wolffram S

更新日期：1996-01-01 00:00:00

abstract：:The conformational properties of the competitive angiotensin II antagonist sarmesin [Sar-Arg-Val-Tyr(Me)-His-Pro-Phe] and its heptapeptide analogue [des1]sarmesin in dimethylsulphoxide-d6 were investigated by nuclear Overhauser effect (NOE) enhancement studies. Assignment of all backbone and side-chain protons was pos...

journal_title：Peptides

authors： Matsoukas JM,Yamdagni R,Moore GJ

更新日期：1990-03-01 00:00:00

abstract：:Endomorphin 1 (EM-1) and EM-2 have been widely reported in the cells of the central nervous system (CNS) but limited research has been done regarding their distribution in the peripheral system. The occurrence of EM-1 and -2 in the spleen as measured by RIA and their ability to mediate immune function imply a role for...

journal_title：Peptides

authors： Seale JV,Jessop DS,Harbuz MS

更新日期：2004-01-01 00:00:00

abstract：:An important role for angiotensin IV (Ang IV) in the processes of learning and memory has now been well established. We have previously found that intracerebroventricular (ICV) administration of Ang IV as well as des-Phe6-Ang IV enhances learning of conditioned avoidance responses (CARs), facilitates recall of a passi...

journal_title：Peptides

authors： Braszko JJ

更新日期：2004-07-01 00:00:00

abstract：:Baboons received a 5-minute intravenous infusion of either saline or bombesin (BBS; 1-4 micrograms/kg) following 3 1/2 or 16 1/2 hours of food deprivation and were then allowed to eat for 30 minutes. Plasma insulin was significantly elevated following five minutes of BBS infusion, but there was no change of plasma glu...

journal_title：Peptides

authors： Woods SC,Stein LJ,Figlewicz DP,Porte D Jr

更新日期：1983-09-01 00:00:00

abstract：:Enzyme-resistant receptor agonists of the incretin hormone glucagon-like peptide-1 (GLP-1) have shown positive therapeutic effects in people with type 2 diabetes mellitus (T2DM). T2DM has detrimental effects on brain function and impairment of cognition and memory formation has been described. One of the underlying me...

journal_title：Peptides

authors： Gault VA,Hölscher C

更新日期：2018-02-01 00:00:00

abstract：:Higher plasma copeptin level has been associated with poor outcomes of critical illness. The present study was undertaken to investigate the plasma copeptin concentrations in children with traumatic brain injury (TBI) and to analyze the correlation of copeptin with disease outcome. Plasma copeptin concentrations of 12...

journal_title：Peptides

authors： Lin C,Wang N,Shen ZP,Zhao ZY

更新日期：2013-04-01 00:00:00

abstract：:Of twelve dipeptides tested, only the Trp containing peptides Val-Trp and its reverse peptide Trp-Val showed a xanthine oxidase (XO) inhibitory activity. Studies with Val and Trp revealed that XO inhibition was mainly attributed to the Trp residue. No significant difference (P ≥ 0.05) was found for the XO inhibitory p...

journal_title：Peptides

authors： Nongonierma AB,Fitzgerald RJ

更新日期：2012-10-01 00:00:00

abstract：:The location of the cells giving rise to the tachykinergic innervation of the rat arcuate nucleus was studied by combining immunohistochemistry and retrograde axonal transport of a protein-gold complex (WGA-ApoHRP-gold). Small volumes (20 nl) of this marker were injected into the arcuate nucleus of the rat. Twenty-fou...

journal_title：Peptides

authors： Magoul R,Onteniente B,Benjelloun W,Tramu G

更新日期：1993-03-01 00:00:00

abstract：:An antifungal peptide with a molecular mass of 9412 and an N-terminal sequence exhibiting notable homology to those of lipid transfer proteins was isolated from seeds of the vegetable Brassica campestris. The purification protocol entailed ion exchange chromatography on Q-Sepharose, affinity chromatography on Affi-gel...

journal_title：Peptides

authors： Lin P,Xia L,Ng TB

更新日期：2007-08-01 00:00:00

abstract：:The neuropeptide calcitonin gene-related peptide (CGRP) may play a role in neurogenic inflammation, tissue remodeling of the uterine cervix, promoting vasodilation, parturition, and processing of sensory information in the spinal cord. CGRP-immunoreactive nerves of the cervix and spinal cord have been studied but cell...

journal_title：Peptides

authors： Pokabla MJ,Dickerson IM,Papka RE

更新日期：2002-03-01 00:00:00

abstract：:Pea albumin 1F (PA1F), a plant peptide isolated from pea seeds, can dramatically increase blood glucose concentration by subcutaneous injection with a dosage of 5 or 10 microg/g (body weight) in normal and type II diabetic mice (KK/upj-Ay). The voltage-dependent anion channel 1 (VDAC-1) has been identified as the PA1F...

journal_title：Peptides

authors： Dun XP,Li FF,Wang JH,Chen ZW

更新日期：2008-06-01 00:00:00

abstract：:The in vitro interaction between five polycationic peptides, buforin II, cecropin P1, indolicidin, magainin II, and ranalexin, and several clinically used antimicrobial agents was evaluated against several clinical isolates of Gram-positive and Gram-negative aerobic bacteria, using the microbroth dilution method. The ...

journal_title：Peptides

authors： Giacometti A,Cirioni O,Del Prete MS,Paggi AM,D'Errico MM,Scalise G

更新日期：2000-08-01 00:00:00

abstract：:Antibiotic therapy for methicillin-resistant Staphylococcus aureus (MRSA) infections is becoming more difficult in hospitals and communities because of strong biofilm-forming properties and multidrug resistance. Biofilm-associated MRSA is not affected by therapeutically achievable concentrations of antibiotics. Theref...

journal_title：Peptides

authors： Dosler S,Mataraci E

更新日期：2013-11-01 00:00:00

abstract：:Effects of pentobarbital, chlordiazepoxide and ethanol were studied alone and in combination with thyrotropin-releasing hormone (TRH), IM, on punished behavior. Key-peck responses of pigeons were maintained by food presentation under a fixed-interval 3-min schedule in which every 30th response produced shock. Moderate...

journal_title：Peptides

authors： Witkin JM,Sickle J,Barrett JE

更新日期：1984-07-01 00:00:00

abstract：:This study was performed to identify the efferents of the dorsal raphe nucleus (DRN), particularly in regard to nociception. Phaseolus vulgaris leucoagglutinin (PHA-L) was microiontophoresed into the DRN and visualized immunocytochemically; PHA-L-immunoreactive (-IR) fibers and terminals were identified in the forebra...

journal_title：Peptides

authors： Sim LJ,Joseph SA

更新日期：1993-01-01 00:00:00

abstract：:While the circadian rhythm of pituitary adrenocorticotropin (ACTH) secretion has been well characterized, the ultradian rhythm has been less thoroughly investigated. To study the episodic nature of ACTH secretion, unrestrained, unanesthetized rats were bled continuously through indwelling jugular venous cannulae and b...

journal_title：Peptides

authors： Carnes M,Brownfield MS,Kalin NH,Lent S,Barksdale CM

更新日期：1986-03-01 00:00:00

abstract：:Legionella pneumophila, the causative agent of Legionnaires' disease, is a waterborne bacteria. It can multiply in man-made water systems and infect people who inhale contaminated droplets. We have previously reported a Staphylococcus warneri strain that display an anti-Legionella activity. In this work, we characteri...

journal_title：Peptides

authors： Verdon J,Berjeaud JM,Lacombe C,Héchard Y

更新日期：2008-06-01 00:00:00

abstract：:We have cloned melanocortin receptors (MCRs) from several species of fish. The MC4R and MC5R subtypes arose early in vertebrate evolution and their primary structure is remarkably conserved. Expression and pharmacological characterization of the MCRs in fish has revealed that they bind and respond to melanocortin pept...

journal_title：Peptides

authors： Schiöth HB,Haitina T,Ling MK,Ringholm A,Fredriksson R,Cerdá-Reverter JM,Klovins J

更新日期：2005-10-01 00:00:00

abstract：:Insulin-like peptides (ILPs) affect a wide variety of biological events, such as metabolism, lifespan, growth and reproduction. Two ILPs (Spoli-ILP1 and Spoli-ILP2) were identified in the cotton leafworm, Spodoptera littoralis, while the functions and developmental characters are not fully understood. In the present s...

journal_title：Peptides

authors： Iga M,Smagghe G

更新日期：2011-03-01 00:00:00

abstract：:Leptin, a hormone secreted by the adipocytes and involved in feeding and energy balance control, has been proposed to modulate alcohol craving in mice and humans. This study evaluated whether leptin modulates alcohol intake in Marchigian Sardinian alcohol-preferring (msP) rats. Rats were offered 10% ethanol either 2h ...

journal_title：Peptides

authors： Polidori C,Luciani F,Fedeli A,Geary N,Massi M

更新日期：2003-09-01 00:00:00