Abstract:
:Insulin-like peptides (ILPs) affect a wide variety of biological events, such as metabolism, lifespan, growth and reproduction. Two ILPs (Spoli-ILP1 and Spoli-ILP2) were identified in the cotton leafworm, Spodoptera littoralis, while the functions and developmental characters are not fully understood. In the present study, we identified the partial sequence of a putative S. littoralis insulin receptor (Spoli-InR) and investigated the stage (age)- and tissue-dependent expression profile of Spoli-InR in addition to Spoli-ILPs during the last larval development and larval-pupal metamorphosis. Spoli-ILP1 and Spoli-ILP2 were specifically expressed in the brain, and their gene expressions were gradually decreased in concert with larval-pupal development. On the other hand, Spoli-InR was expressed in all the selected tissues (brain, testis, fat body, Malpighian tubules, prothoracic glands and midgut), though the gene expression pattern was different among the tissues. Interestingly, the transcript expression pattern of Spoli-InR in the fat body seemed to relate with larval-pupal development. In a parallel experiment, the juvenile hormone mimetic methoprene was able to prolong the larval period when applied before the commitment peak of ecdysteroids titer in the hemolymph, and in this case the expression of Spoli-ILPs and Spoli-InR was affected. These results demonstrated first a relationship between transcript expression of Spoli-ILPs and larval-pupal development, and second they suggested the effect of ILPs may be controlled by not only Spoli-ILPs expression but also Spoli-InR expression.
journal_name
Peptidesjournal_title
Peptidesauthors
Iga M,Smagghe Gdoi
10.1016/j.peptides.2010.10.033subject
Has Abstractpub_date
2011-03-01 00:00:00pages
531-8issue
3eissn
0196-9781issn
1873-5169pii
S0196-9781(10)00486-9journal_volume
32pub_type
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