Abstract:
:Arginine-vasopressin (AVP) is a hypothalamic hormone that, like CRH, stimulates the pituitary release of ACTH, thereby activating adrenal glucocorticoid secretion. Evidence indicates that rat adrenal medulla contains a CRH-ACTH system duplicating that existing at the hypothalamo-pituitary level and involved in the paracrine stimulation of the cortex secretion. Therefore, we investigated by RIA the effect of AVP on the release of CRH and ACTH immunoreactivities (IR) by rat adrenal medulla in vitro. AVP concentration-dependently enhanced the release of both CRH-IR and ACTH-IR, and the effect was blocked by a selective antagonist of the V1 subtype of AVP receptors. The CRH receptor antagonist alpha-helical-CRH partially reversed AVP-evoked rise in ACTH-IR release, without altering either CRH response or basal secretions of CRH and ACTH. The specific inhibitors of protein kinase C Ro31-8220 and calphostin C abolished both CRH and ACTH responses to AVP. In conclusion, our present findings suggest that AVP stimulates intramedullary the CRH-ACTH system, acting via V1 receptors and activating protein kinase C.
journal_name
Peptidesjournal_title
Peptidesauthors
Mazzocchi G,Malendowicz LK,Rebuffat P,Tortorella C,Nussdorfer GGdoi
10.1016/s0196-9781(96)00294-xsubject
Has Abstractpub_date
1997-01-01 00:00:00pages
191-5issue
2eissn
0196-9781issn
1873-5169pii
S0196-9781(96)00294-Xjournal_volume
18pub_type
杂志文章相关文献
PEPTIDES文献大全abstract::Higher plasma copeptin level has been associated with poor outcomes of critical illness. The present study was undertaken to investigate the plasma copeptin concentrations in children with traumatic brain injury (TBI) and to analyze the correlation of copeptin with disease outcome. Plasma copeptin concentrations of 12...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2013.01.015
更新日期:2013-04-01 00:00:00
abstract::Angiotensin(1-7) had a compound effect on blood pressure of pithed Sprague-Dawley rats. The initial phase of the response consisted of an increase in MAP of short duration and independent of injected dose, followed by a decline of arterial pressure to values below baseline. Both the magnitude (range: -4 +/- 1 to -13 +...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(93)90097-z
更新日期:1993-07-01 00:00:00
abstract::The neuropeptide S (NPS) system is characterized by a unique pharmacology because it has anxiolytic-like effects and promotes arousal and wakefulness. To shed light on this peptidergic system, we tested the sedative effect of the central depressants diazepam and ethanol on the loss of righting reflex in mice lacking t...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2014.09.010
更新日期:2014-11-01 00:00:00
abstract::A bradykinin (BK)-related peptide was isolated from heat-denaturated plasma from an elasmobranch fish, the little skate, Leucoraja erinacea after incubation with porcine pancreatic kallikrein. The primary structure of the peptide (H-Gly-Ile-Thr-Ser-Trp-Leu-Pro-Phe-OH; skate BK) shows limited structural similarity to t...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2008.04.006
更新日期:2008-08-01 00:00:00
abstract::The effects of acute and subchronic administration of chlordiazepoxide (CDZ) on [3H][3-methyl-histidyl2]thyrotropin-releasing hormone binding to thyrotropin-releasing hormone (TRH) receptors in membrane preparations from various regions of rat brain were examined. Acute administration of CDZ (50 mg/kg x 3 within 24 h)...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(91)90188-u
更新日期:1991-01-01 00:00:00
abstract::Previously, we described a gene, flp-1, that encodes seven FMRFamide-like peptides from two alternatively spliced transcripts in the nematode Caenorhabditis elegans. To determine whether all or a subset of the predicted peptides coded for by flp-1 are produced in vivo, we undertook the isolation of FMRFamide-like pept...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(93)90049-m
更新日期:1993-03-01 00:00:00
abstract::Endomorphin1-ol (Tyr-Pro-Trp-Phe-ol, EM1-ol) and endomorphin2-ol (Tyr-Pro-Phe-Phe-ol, EM2-ol), with C-terminal alcohol (-ol) containing, have been shown to exhibit higher affinity and lower intrinsic efficacy in vitro than endomorphins. In the present study, in order to investigate the alterations of systemic hemodyna...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2005.07.006
更新日期:2006-01-01 00:00:00
abstract::The distributions of neuropeptides in paraffin-embedded tissue sections (PETS) of the eyestalk, brain, and thoracic ganglia of the shrimp Penaeus monodon were visualized by imaging mass spectrometry (IMS). Peptide signals were obtained from PETS without affecting morphological features. Twenty-nine neuropeptides compr...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2011.03.021
更新日期:2012-03-01 00:00:00
abstract::Members of the neprilysin family of neutral endopeptidases (M13) are typically membrane-bound enzymes known to be involved in the extra-cellular metabolism of signalling peptides and have important roles during mammalian embryogenesis. In this study we show that membranes prepared from embryos of Drosophila melanogast...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2006.08.032
更新日期:2007-01-01 00:00:00
abstract::Although the biological effects of adrenomedullin (AM) and PAMP have been reported extensively in animal studies and from in-vitro experiments, relatively little information is available on responses to the hormone administered to man. This review summarizes data from the few studies carried out in man. In healthy vol...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/s0196-9781(01)00508-3
更新日期:2001-11-01 00:00:00
abstract::One major cause for discrepancies in results from animal experimental studies is the use of different animal strains and suppliers. We have previously reported that Wistar rats from five different suppliers display profound differences in ethanol intake and behavior. One of the neurobiological processes that could be ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.04.016
更新日期:2012-07-01 00:00:00
abstract::The elevated T-maze was combined with a free exploration protocol, which, in contrast to the conventional procedure, dispenses with handling of the animals during the experimental sessions. This allows measurement of fear indexes derived from the elevated plus-maze as well as assessment of acquisition of open arm avoi...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(01)00421-1
更新日期:2001-07-01 00:00:00
abstract::In this study, we present evidence showing that endothelin (ET) potentiates the responses to adenosine, to 5'-N-ethylcarboxamidoad, a nonhydrolyzable adenosine agonist, and to isoprenaline. These responses seem to occur through ET-B receptors, as all three endothelin isopeptides have the same potency, sarafotoxin 6c h...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(99)00108-4
更新日期:1999-01-01 00:00:00
abstract::This study sought to determine the serum levels of chemerin in gastric cancer patients and healthy subjects and to investigate the biological effect of chemerin on gastric cancer cells. Serum chemerin level of 36 gastric cancer patients and 40 healthy subjects was measured by enzyme-linked immunosorbent assay. AGS and...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2013.10.009
更新日期:2014-01-01 00:00:00
abstract::Just as the blood-brain barrier (BBB) is not a static barrier, the adipocytes are not inert storage depots. Adipokines are peptides or polypeptides produced by white adipose tissue; they play important roles in normal physiology as well as in the metabolic syndrome. Adipokines secreted into the circulation can interac...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2007.04.023
更新日期:2007-06-01 00:00:00
abstract::Studies involving altered energy balance states in rodents have demonstrated that hypothalamic neuropeptide Y (NPY) activity is strongly activated in states of negative energy balance, such as periods of dietary restriction or starvation. However, in cancer cachexia, when there is a significant reduction in body weigh...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(99)00183-7
更新日期:2000-01-01 00:00:00
abstract::Beta-amyloid (Aβ) peptides are secreted from neurons, resulting in extracellular accumulation of Aβ and neurodegeneration of Alzheimer's disease. Because neuronal secretion is fundamental for the release of neurotransmitters, this study assessed the hypothesis that Aβ undergoes co-release with neurotransmitters. Model...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2013.04.020
更新日期:2013-08-01 00:00:00
abstract::Insulin in blood is thought to cross the blood-brain barrier (BBB) to act within the brain to help control appetite. We examined the ability of blood-borne insulin to cross the BBB. Human insulin was infused for 48 h subcutaneously at several doses into mice and the amount of human and murine insulin in serum and brai...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(97)00198-8
更新日期:1997-01-01 00:00:00
abstract::The purpose of this investigation was to determine the influence of long-distance running on the secretion of the gastrointestinal peptide hormones cholecystokinin (CCK) and gastrin. Several known stress hormones, ACTH, cortisol and norepinephrine, were also measured. The hormones were estimated before and after a com...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(92)90150-2
更新日期:1992-01-01 00:00:00
abstract::Gastrin/CCK peptides in extracts from bovine and porcine pituitary have been characterized by Sephadex gel filtration, reverse phase liquid chromatography and a CCK radioimmunoassay (RIA) which detects both CCK and gastrin [4]. Porcine pituitary extracts contain a small amount of two peptides with chromatographic beha...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(82)90121-8
更新日期:1982-05-01 00:00:00
abstract::The effect of naturally occurring cannabinoids, delta 9-tetrahydrocannabinol (THC), cannabinol (CBN) and cannabidiol (CBD), on the brain receptors for thyrotropin releasing hormone (TRH) was investigated. TRH receptors were labeled with 3H-(3-MeHis2)TRH (3H-MeTRH). 3H-MeTRH bound specifically to rat brain membranes at...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(88)90120-9
更新日期:1988-07-01 00:00:00
abstract::The purpose of this study was to examine the resting and exercise response patterns of plasma Peptide F immunoreactivity (ir) to altitude exposure (4300 m) and caffeine ingestion (4 mg.kg b.w.-1). Nine healthy male subjects performed exercise tests to exhaustion (80-85% VO2max) at sea level (50 m), during an acute alt...
journal_title:Peptides
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0196-9781(88)90098-8
更新日期:1988-09-01 00:00:00
abstract::VIP and secretin control the secretory function of the normal pancreas. We analysed their regulatory functions in a human pancreatic cancer cell line: Capan-1. Saturation binding experiments with 125I-VIP showed the existence of one class of binding sites of very high affinity: KD 6.4 +/- 3.0 X 10(-11) M and a low Bma...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(86)90200-7
更新日期:1986-01-01 00:00:00
abstract::A new CCK8 related peptide, Boc[Nle28,Nle31]CCK27-33 (Boc[diNle]CCK7) was synthesized and tested for cholecystokinic activity, at both the peripheral and the central level. This analogue, protected against both chemical oxidation and enzymatic degradation by aminopeptidases, was shown to be equipotent to CCK8 in relea...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(85)90106-8
更新日期:1985-05-01 00:00:00
abstract::Calcification-associated peptide (CAP)-1 is considered to play an important role in calcification of the exoskeleton of the crayfish, Procambarus clarkii. In this study, in order to clarify the molecular mechanism of calcification, we constructed expression systems of recombinant molecules of CAP-1 and its related pep...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2006.12.005
更新日期:2007-03-01 00:00:00
abstract::We applied computational biology to identify the linear amino acid sequence recognized by a mouse monoclonal antibody raised against the full length HPV16 E7 oncoprotein. Computer-assisted search for the epitopic peptide used two parameters: the capability of E7 peptides to bind to MHC class II molecules, and the simi...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(01)00539-3
更新日期:2001-12-01 00:00:00
abstract::Cationic antibacterial peptides are produced in all living organisms and possess either selective activity toward a certain type of cell or microorganism, or a broad spectrum of activity toward several types of cells including prokaryotic and mammalian cells. In order to exert their activity, peptides first interact w...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2003.09.013
更新日期:2003-11-01 00:00:00
abstract::We have attempted to demonstrate a pancreatic secretory response to intraduodenal amino acids in the anesthetized cat. In four cats stimulated with supramaximal doses of secretin, protein concentrations in pancreatic juice were measured after intraduodenal bolus injection of various amino acids, IV CCK, or electrical ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(82)90040-7
更新日期:1982-03-01 00:00:00
abstract::A new series of analogues of the potent opiate-like peptides dermorphins (mainly tetra- and pentapeptides) were synthesized in order to better evaluate the structure-activity relationships. Relative potencies were referred to dermorphin (H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2), the prototype of this class of frog skin pe...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(82)90009-2
更新日期:1982-09-01 00:00:00
abstract::Ghrelin is a peptide that has protective effects on many tissues of the body. It has anti-inflammatory and anti-oxidant effects. Acetaminophen, a commonly used analgesic-antipyretic drug, has hepatotoxic side effects. The aim of this study was to evaluate the protective role of ghrelin in liver toxicity due to acetami...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2010.08.009
更新日期:2010-11-01 00:00:00