当前位置： SCI文献检索 > PEPTIDES期刊下所有文献 > Can we predict biological activity of antimicrobial peptides from their interactions with model phospholipid membranes?

Can we predict biological activity of antimicrobial peptides from their interactions with model phospholipid membranes?

Abstract：

:Cationic antibacterial peptides are produced in all living organisms and possess either selective activity toward a certain type of cell or microorganism, or a broad spectrum of activity toward several types of cells including prokaryotic and mammalian cells. In order to exert their activity, peptides first interact with and traverse an outer barrier, e.g., mainly LPS and peptidoglycan in bacteria or a glycocalix layer and matrix proteins in mammalian cells. Only then, can the peptides bind and insert into the cytoplasmic membrane. The mode of action of many antibacterial peptides is believed to be the disruption of the lipidic plasma membrane. Therefore, model phospholipid membranes have been used to study the mode of action of antimicrobial peptides. These studies have demonstrated that peptides that act preferentially on bacteria are also able to interact with and permeate efficiently anionic phospholipids, whereas peptides that lyse mammalian cells bind and permeate efficiently both acidic and zwitterionic phospholipids membranes, mimicking the plasma membranes of these cells. It is now becoming increasingly clear that selective activity of these peptides against different cells depends also on other parameters that characterize both the peptide and the target cell. With respect to the peptide's properties, these include the volume of the molecule, its structure, and its oligomeric state in solution and in membranes. Regarding the target membrane, these include the structure, length, and complexity of the hydrophilic polysaccharide found in its outer layer. These parameters affect the ability of the peptides to diffuse through the cell's outer barrier and to reach its cytoplasmic plasma membrane.

journal_name

Peptides

journal_title

Peptides

authors

Papo N,Shai Y

doi

10.1016/j.peptides.2003.09.013

subject

Has Abstract

pub_date

2003-11-01 00:00:00

pages

1693-703

issue

11

eissn

0196-9781

issn

1873-5169

pii

S0196978103003437

journal_volume

24

pub_type

杂志文章,评审

相关文献

PEPTIDES文献大全
  • Local renin-angiotensin systems in the adrenal gland.

    abstract：:In the adrenal gland all components of the renin-angiotensin system (RAS) are expressed in both the adrenal cortex and the adrenal medulla. In this review evidence shall be presented that a local secretory RAS exists in the adrenal cortex that stimulates aldosterone production and serves as an amplification system for...

    journal_title：Peptides

    pub_type： 杂志文章,评审

    doi：10.1016/j.peptides.2012.01.023

    authors： Peters J

    更新日期：2012-04-01 00:00:00

  • Inhibition of malaria parasite Plasmodium falciparum development by crotamine, a cell penetrating peptide from the snake venom.

    abstract：:We show here that crotamine, a polypeptide from the South American rattlesnake venom with cell penetrating and selective anti-fungal and anti-tumoral properties, presents a potent anti-plasmodial activity in culture. Crotamine inhibits the development of the Plasmodium falciparum parasites in a dose-dependent manner [...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/j.peptides.2016.01.013

    authors： El Chamy Maluf S,Dal Mas C,Oliveira EB,Melo PM,Carmona AK,Gazarini ML,Hayashi MA

    更新日期：2016-04-01 00:00:00

  • Suppression of feeding by cholecystokinin but not bombesin is attenuated in dorsomedial hypothalamic nuclei lesioned rats.

    abstract：:Rats with dorsomedial hypothalamic lesions (DMN-L) or sham operations were injected IP with saline or the satiety peptide cholecystokinin (CCK) at 3.0 and 6.0 micrograms/kg at the onset of the dark phase. Food consumption was then measured 15, 30 and 60 min later. Compared to saline baseline intake, CCK suppressed fee...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/0196-9781(84)90085-8

    authors： Bellinger LL,Bernardis LL

    更新日期：1984-05-01 00:00:00

  • Characterization of binding sites of a memory-enhancing peptide AVP(4-8) in rat cortical synaptosomal membranes.

    abstract：:The pentapeptide pGlu-Asn-Cyt-Pro-Arg [AVP(4-8), termed ZNC(C)PR in this article] has been found as a metabolite of arginine-vasopressin (AVP) in rat brain and has been shown to have potent memory-enhancing activity and to yield a series of biochemical events in brain tissues. [35S]ZNC(C)PR was chemically synthesized ...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/0196-9781(94)90153-8

    authors： Du YC,Wu JH,Jiang XM,Gu YJ

    更新日期：1994-01-01 00:00:00

  • Opiocortin and catecholamine input to CRF-immunoreactive neurons in rat forebrain.

    abstract：:Neural input to distinct and separate populations of CRF-immunoreactive (ir) neurons in rat forebrain was investigated. The relationship of opiocortin and/or catecholamine fibers to different groups of CRF-containing neurons was elucidated using single and dual labeling immunocytochemical procedures. Antibodies to CRF...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/0196-9781(89)90005-3

    authors： Hornby PJ,Piekut DT

    更新日期：1989-11-01 00:00:00

  • Glutamate antagonists attenuate the action of NC-1900, a vasopressin fragment analog, on passive avoidance task performance in mice.

    abstract：:To examine the relationship between glutamate receptors and the action of NC-1900 on a step-through passive avoidance (PA) task in mice, MK-801, an NMDA receptor blocker, and (S)-4-carboxyphenylglycine (4CPG), a group I metabotropic receptor antagonist, were administered intraventricularly (i.c.v.) singly or as co-inj...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/j.peptides.2004.12.014

    authors： Sato T,Ishida T,Tanaka K,Chowdhurry N,Irifune M,Hirate K,Mimura T,Nishikawa T

    更新日期：2005-05-01 00:00:00

  • 1H-NMR studies of sarmesin and [des1]sarmesin conformation in dimethylsulfoxide by nuclear Overhauser effect (NOE) enhancement spectroscopy: folding of the N- and C-terminal domains.

    abstract：:The conformational properties of the competitive angiotensin II antagonist sarmesin [Sar-Arg-Val-Tyr(Me)-His-Pro-Phe] and its heptapeptide analogue [des1]sarmesin in dimethylsulphoxide-d6 were investigated by nuclear Overhauser effect (NOE) enhancement studies. Assignment of all backbone and side-chain protons was pos...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/0196-9781(90)90094-l

    authors： Matsoukas JM,Yamdagni R,Moore GJ

    更新日期：1990-03-01 00:00:00

  • Differential regulation of human cathelicidin LL-37 by free fatty acids and their analogs.

    abstract：:LL-37 is the single cathelicidin host defense peptide in humans with direct antimicrobial and immunomodulatory activities. Specific regulation of LL-37 synthesis has emerged as a novel non-antibiotic approach to disease control and prevention. Short-chain fatty acids, and butyrate in particular, were found recently to...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/j.peptides.2013.10.008

    authors： Jiang W,Sunkara LT,Zeng X,Deng Z,Myers SM,Zhang G

    更新日期：2013-12-01 00:00:00

  • A comparison of leptin and ghrelin levels in plasma and saliva of young healthy subjects.

    abstract：:In the last 10 years, saliva has been increasingly used as a diagnostic fluid and in predictions of disease progression. Leptin and ghrelin are synthesized in several tissues including the salivary glands. The action of ghrelin is antagonistic to that of leptin. This study was undertaken to measure and compare the sal...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/j.peptides.2004.11.008

    authors： Aydin S,Halifeoglu I,Ozercan IH,Erman F,Kilic N,Aydin S,Ilhan N,Ilhan N,Ozkan Y,Akpolat N,Sert L,Caylak E

    更新日期：2005-04-01 00:00:00

  • Pancreatic polypeptide: identification of target tissues using an in vivo radioreceptor assay.

    abstract：:The definitive function of pancreatic polypeptide in mammalian physiology remains unknown. The identification of specific PP target tissues should be helpful to further investigations into the possible regulatory actions of this peptide. An in vivo radioreceptor assay was used in the rat to locate potential binding si...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/s0196-9781(97)00372-0

    authors： Shetzline MA,Zipf WB,Nishikawara MT

    更新日期：1998-01-01 00:00:00

  • Distribution and characterization of endozepine-like immunoreactivity in the central nervous system of the frog Rana ridibunda.

    abstract：:The localization of endozepine-like immunoreactivity in the brain of the frog Rana ridibunda was investigated by indirect immunofluorescence, using an antiserum against synthetic rat octadecaneuropeptide (ODN). A specific immunoreaction was detected in ependymal cells lining the ventricular system of the brain and in ...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/0196-9781(92)90146-t

    authors： Malagon M,Vaudry H,Vallarino M,Gracia-Navarro F,Tonon MC

    更新日期：1992-01-01 00:00:00

  • Selective inhibition of the binding of 3H-(3-MeHis2) thyrotropin releasing hormone to rat amygdala membranes by some naturally occurring cannabinoids.

    abstract：:The effect of naturally occurring cannabinoids, delta 9-tetrahydrocannabinol (THC), cannabinol (CBN) and cannabidiol (CBD), on the brain receptors for thyrotropin releasing hormone (TRH) was investigated. TRH receptors were labeled with 3H-(3-MeHis2)TRH (3H-MeTRH). 3H-MeTRH bound specifically to rat brain membranes at...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/0196-9781(88)90120-9

    authors： Bhargava HN,Gulati A

    更新日期：1988-07-01 00:00:00

  • Neuropeptide Y, ubiquitous and elusive.

    abstract：:This paper reviews aspects of NPY research that were emerging in 1985, shortly after the isolation and characterization of the peptide. NPY had become known for its widespread distribution especially in the central and peripheral nervous systems, but also in the gastro-intestinal and respiratory tracts and in fibers i...

    journal_title：Peptides

    pub_type： 杂志文章,评审

    doi：10.1016/j.peptides.2004.02.013

    authors： Chronwall BM,Zukowska Z

    更新日期：2004-03-01 00:00:00

  • Neuropeptides interact with glycolipid receptors: a surface plasmon resonance study.

    abstract：:Using Surface Plasmon Resonance (SPR) we investigated the interaction of seven neuropeptides with different characteristics and beta-amyloid (Abeta42) peptide, with membranes containing gangliosides. A wide range of affinities characterized the bindings (K(D) = 10(-3)- 10(-7) M), following the scheme: for GM1, Abeta42...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/s0196-9781(01)00432-6

    authors： Valdes-Gonzalez T,Inagawa J,Ido T

    更新日期：2001-07-01 00:00:00

  • Alpha-human atrial natriuretic polypeptide (alpha-hANP) in normal volunteers and patients with heart failure or hypertension.

    abstract：:The presence of alpha-hANP immunoreactive material in human heart and plasma was investigated with a specific and sensitive radioimmunoassay and immunohistochemical method. It was found that alpha-hANP immunoreactive staining of specific atrial granules was located around the nucleus of atrial cardiocytes. No immunore...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/0196-9781(86)90057-4

    authors： Tang J,Song DL,Suen MZ,Xie CW,Chang D,Chang JK

    更新日期：1986-01-01 00:00:00

  • Cardiopulmonary pharmacology of enkephalins in the conscious dog.

    abstract：:Various enkephalins (ENK) have been reported to alter heart rate, systemic blood pressure, and respiratory function but with variable results. We previously found that pentobarbital anesthesia reversed the increases in heart rate and systemic arterial blood pressure produced by Leu5-ENK in the dog. We have now studied...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/s0196-9781(81)80095-2

    authors： Sander GE,Giles TD,Kastin AJ,Quiroz AC,Kaneish A,Coy DH

    更新日期：1981-01-01 00:00:00

  • Characterization of neurotensin binding to rat gastric smooth muscle receptor sites.

    abstract：:The binding of monoiodo 125I-Trp11-neurotensin to purified rat gastric fundus smooth muscle plasma membranes was characterized. Specific binding of ligand in subcellular fractions from rat fundus smooth muscle showed a distribution that paralleled that of several plasma membrane marker enzymes. 125I-Trp11-neurotensin ...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/0196-9781(84)90117-7

    authors： Kitabgi P,Kwan CY,Fox JE,Vincent JP

    更新日期：1984-09-01 00:00:00

  • Peptide hormones in strange places--are they there?

    abstract：:Are ACTH and insulin synthesized in tissues other than the pituitary and pancreas, respectively? ACTH and TSH are widely distributed in the rat brain but are restricted to the hypothalamic regions of the primate brain. It is concluded that these pituitary peptides are not synthesized in the brain in extrahypothalamic ...

    journal_title：Peptides

    pub_type： 杂志文章,评审

    doi：10.1016/0196-9781(81)90004-8

    authors： Yalow RS,Eng J

    更新日期：1981-01-01 00:00:00

  • Localization of neuropeptide Y and its C-terminal flanking peptide in human renal tissue.

    abstract：:We produced and characterized three anti-C-flanking peptides of neuropeptide Y (CPON) monoclonal antibodies. The Ka for these antibodies ranged from 0.4 to 0.8 x 10(8) l/mol with an IC50 for CPON(1-30) at about 20 nM as determined by ELISA. All these antibodies are IgG1 and recognize the 16-30 part of CPON. These anti...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/0196-9781(94)90112-0

    authors： Grouzmann E,Alvarez-Bolado G,Meyer C,Osterheld MC,Burnier M,Brunner HR,Waeber B

    更新日期：1994-01-01 00:00:00

  • Insulin in the vitreous of the normal and streptozotocin-induced diabetic rat.

    abstract：:Insulin has been detected by ELISA in the vitreous of the normal and streptozotocin-diabetic rat at levels for both about 1% of those in serum. 131I-labeled insulin, administered to conscious rats via an indwelling cannula in the right atrium, was found to cross the blood-ocular barrier into the vitreous. Autoradiogra...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/0196-9781(92)90171-x

    authors： Shires TK,Braddock KJ,Pulido JS

    更新日期：1992-07-01 00:00:00

  • Correlation of structural changes in parathyroid hormone with its vascular action.

    abstract：:The analysis of the spectrum of circular dichroism (CD) of methionine-oxidized bovine parathyroid hormone peptide, bPTH(1-34) revealed that approximately 43% of the orderly conformation (alpha-helix and beta-sheet) was converted into random coil structure. This peptide failed to elicit any hypotensive response in rats...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/0196-9781(86)90143-9

    authors： Hong BS,Yang MC,Liang JN,Pang PK

    更新日期：1986-11-01 00:00:00

  • Purification and characterization of alpha- and beta-benincasins, arginine/glutamate-rich peptides with translation-inhibiting activity from wax gourd seeds.

    abstract：:Two peptides, with a molecular mass of about 11 kDa and an N-terminal sequence abundant in arginine and glutamine residues, were isolated from wax gourd seeds. The isolation protocol included affinity chromatography on Affi-gel blue gel, ion-exchange chromatography on Mono-S and gel filtration on Superdex 75. The pept...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/s0196-9781(02)00271-1

    authors： Ng TB,Parkash A,Tso WW

    更新日期：2003-01-01 00:00:00

  • Synthesis of (S)-3-(1-hydroxy-p-carboran-12-yl)alanine, a novel hydrophobic tyrosine-mimetic for peptides.

    abstract：:A new, p -carborane containing analog of tyrosine, 3-[1-hydroxy-1,12-dicarba-closo-dodecaboran (12)-12-yl]alanine, was prepared from protected 3-[1-hydroxy-1,12-dicarba-closo-dodecaboran (12)-12-yl]propionic acid in five steps using Oppolzer's sultam methodology for asymmetric hydroxyamination as the key step. The tyr...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/s0196-9781(01)00650-7

    authors： Ujváry I,Nachman RJ

    更新日期：2002-04-01 00:00:00

  • New insights and perspectives on intrarenal renin-angiotensin system: focus on intracrine/intracellular angiotensin II.

    abstract：:Although renin, the rate-limiting enzyme of the renin-angiotensin system (RAS), was first discovered by Robert Tigerstedt and Bergman more than a century ago, the research on the RAS still remains stronger than ever. The RAS, once considered to be an endocrine system, is now widely recognized as dual (circulating and ...

    journal_title：Peptides

    pub_type： 杂志文章,评审

    doi：10.1016/j.peptides.2011.05.012

    authors： Zhuo JL,Li XC

    更新日期：2011-07-01 00:00:00

  • Synthesis of bombyxin-IV, an insulin-like heterodimeric peptide from the silkworm, Bombyx mori.

    abstract：:Bombyxin-IV, a molecular species of bombyxin, which is a member of insulin-like heterodimeric peptides of the silkworm Bombyx mori with prothoracicotropic hormone activity, was synthesized. The A- and B-chains of bombyxin-IV containing four and two Cys residues, respectively, were first synthesized separately by solid...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/0196-9781(90)90126-p

    authors： Maruyama K,Nagasawa H,Isogai A,Tamura S,Ishizaki H,Suzuki A

    更新日期：1990-01-01 00:00:00

  • Alteration of NPY and Y1 receptor in dorsomedial and ventromedial areas of hypothalamus in anorectic tumor-bearing rats.

    abstract：:Although previous studies have implicated NPY in the etiology of experimental cancer anorexia, the results have been difficult to interpret. Studies have suggested that although NPY level and message were decreased in the dorsomedial hypothalamic area (DMA), they were elevated in the ventromedial hypothalamic area (VM...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/j.peptides.2006.10.018

    authors： Chance WT,Xiao C,Dayal R,Sheriff S

    更新日期：2007-02-01 00:00:00

  • Effects of various peptides on isolated rabbit lower esophageal sphincter.

    abstract：:Strips of lower esophageal sphincter (LES) from rabbits were tested for their responses to several peptides, and to electrical field stimulation (EFS) under the presence of some peptides. Substance P (SP), motilin, and bombesin induced contraction, and vasoactive intestinal peptide (VIP) induced relaxation. SP- and bo...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/0196-9781(96)00137-4

    authors： Kohjitani A,Shirakawa J,Okada S,Obara H

    更新日期：1996-01-01 00:00:00

  • Characterization of growth hormone-releasing hormone (GHRH) binding to cloned porcine GHRH receptor.

    abstract：:To study structure-activity relationships of growth hormone-releasing hormone (GHRH), a competitive binding assay was developed using cloned porcine adenopituitary GHRH receptors expressed in human kidney 293 cells. Specific binding of [His1, 125I-Tyr10,Nle27]hGHRH(1-32)-NH2 increased linearly with protein concentrati...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/0196-9781(95)02026-8

    authors： Hassan HA,Hsiung HM,Zhang XY,Smith DP,Smiley DL,Heiman ML

    更新日期：1995-01-01 00:00:00

  • LmrBPP9: A synthetic bradykinin-potentiating peptide from Lachesis muta rhombeata venom that inhibits the angiotensin-converting enzyme activity in vitro and reduces the blood pressure of hypertensive rats.

    abstract：:Bradykinin-potentiating peptides (BPPs) are an important group of toxins present in Lachesis muta rhombeata venom. They act directly at renin-angiotensin-aldosterone system, through the inhibition of angiotensin-converting enzyme (ACE). This action may contribute to the hypotensive shock observed during the envenoming...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/j.peptides.2018.01.015

    authors： Pinheiro-Júnior EL,Boldrini-França J,de Campos Araújo LMP,Santos-Filho NA,Bendhack LM,Cilli EM,Arantes EC

    更新日期：2018-04-01 00:00:00

  • Orexin receptor type-1 antagonist SB-334867 inhibits the development of morphine analgesic tolerance in rats.

    abstract：:Herein the effect of orexin receptor type-1 antagonist SB-334867 on the development of tolerance to analgesic effects of morphine was studied in rats. To incite tolerance, morphine sulfate was injected intraperitoneally (i.p., 10mg/kg) once a day for 7 days. The tail flick test was used to evaluate antinociceptive eff...

    journal_title：Peptides

    pub_type： 杂志文章

    doi：10.1016/j.peptides.2012.02.023

    authors： Ranjbar-Slamloo Y,Azizi H,Fathollahi Y,Semnanian S

    更新日期：2012-05-01 00:00:00