Abstract:
:Dissociated neurointermediate lobe cells (75%) bound [biotinyl-Ser1]corticotropin releasing hormone (bio-CRH) and secreted adrenocorticotropin [ACTH(25-39)] in a reverse hemolytic plaque assay (RHPA). The bio-CRH was rapidly internalized (less than 1 min) in vesicles and scattered vacuoles. Plaque percentages increased from 26 +/- 4% to 53 +/- 8% after CRH stimulation. Areas increased from 1688 +/- 791 microns 2 to 3773 +/- 788 microns 2. After AVP treatment for 1 hr, plaque percentages and areas were augmented further. The heterogeneity in secretion may indicate the presence of quiescent IL cells or cells secreting an opiocortin peptide not detected in the plaque assay.
journal_name
Peptidesjournal_title
Peptidesauthors
Childs GVdoi
10.1016/0196-9781(90)90188-bsubject
Has Abstractpub_date
1990-07-01 00:00:00pages
729-36issue
4eissn
0196-9781issn
1873-5169pii
0196-9781(90)90188-Bjournal_volume
11pub_type
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