Relationship of alpha MSH-specific neurons to the arcuate opiocortin neuronal system as determined by dual antigen immunocytochemical procedures.

abstract：:Several cardioactive peptides from the pulmonate snail Helix aspersa were tested for their effects on myocardial cAMP levels, but only the family of small cardioactive peptides (SCPs) were clearly effective. SCP increased cAMP in a dose dependent manner; the time course was phasic. The structure-activity relations of ...

journal_title：Peptides

authors： Reich G,Doble KE,Price DA,Greenberg MJ

更新日期：1997-01-01 00:00:00

abstract：:The neuropharmacological basis for d-amphetamine induced paradoxical behavioral thermoregulation remains unclear. This study examined thermoregulatory behavior of rats in a runway device that housed a heat source at one end and in which locomotion along the length of the runway could be observed. Sprague Dawley rats w...

journal_title：Peptides

authors： Yehuda S,Sheleff P

更新日期：1985-03-01 00:00:00

abstract：:The present status of our understanding of the feedback regulation of pancreatic secretion by peptide YY (PYY) released from the distal intestine is reviewed. Exocrine pancreatic secretion is primarily controlled by the cephalic (the vagus nerve), gastric (acid and pepsin secretion, and nutrients delivered into the du...

journal_title：Peptides

authors： Naruse S,Kitagawa M,Ishiguro H,Hayakawa T

更新日期：2002-02-01 00:00:00

abstract：:Cardiac hypertrophy, an adaptive process to an increased hemodynamic overload, includes not only an increase in cell size but also qualitative changes in constituent proteins. Although swelling-activated chloride channels (I(Cl,swell)) chronically activate in hypertrophied atrial myocytes, the role of I(Cl,swell) in r...

journal_title：Peptides

authors： Bai GY,Yuan K,Park WH,Kim SZ,Kim SH

更新日期：2008-09-01 00:00:00

abstract：:The degradation of synthetic Manduca sexta allatostatin (Manse-AS) and allatotropin (Manse-AT), by enzymes of the foregut of larvae of the tomato moth, Lacanobia oleracea was investigated using reversed-phase high performance liquid chromatography (RP-HPLC) together with matrix-assisted laser desorption ionization-tim...

journal_title：Peptides

authors： Audsley N,Weaver RJ,Edwards JP

更新日期：2002-11-01 00:00:00

abstract：:Adjacent tissue sections through the rat median eminence were examined for the distribution of gonadotropin-releasing hormone (GnRH) and catecholamines (CA). A simultaneous visualization technique was employed for this correlative neuroanatomical analysis. At rostral and mid-central levels of the median eminence the m...

journal_title：Peptides

authors： McNeill TH,Scott DE,Sladek JR Jr

更新日期：1980-04-01 00:00:00

abstract：:The endangered anuran species, Odorrana ishikawae, is endemic to only two small Japanese Islands, Amami and Okinawa. To assess the innate immune system in this frog, we investigated antimicrobial peptides in the skin using artificially bred animals. Nine novel antimicrobial peptides containing the C-terminal cyclic he...

journal_title：Peptides

authors： Iwakoshi-Ukena E,Ukena K,Okimoto A,Soga M,Okada G,Sano N,Fujii T,Sugawara Y,Sumida M

更新日期：2011-04-01 00:00:00

abstract：:Bacillus thuringiensis Cry toxins recognizes their target cells in part by the binding to glycosyl-phosphatidyl-inositol (GPI) anchored proteins such as aminopeptidase-N (APN) or alkaline phosphatases (ALP). Treatment of Tenebrio molitor brush border membrane vesicles (BBMV) with phospholipase C that cleaves out GPI-a...

journal_title：Peptides

authors： Zúñiga-Navarrete F,Gómez I,Peña G,Bravo A,Soberón M

更新日期：2013-03-01 00:00:00

abstract：:Locust abdominal ganglia are shown to colocalize Locusta-diuretic peptide-, leucokinin I-, and lysine vasopressin-like immunoreactivity in posterior lateral neurosecretory cells. Extracts of abdominal ganglia were partially purified by RP-HPLC then dot immunoassay screened with the same antisera used for immunocytoche...

journal_title：Peptides

authors： Thompson KS,Rayne RC,Gibbon CR,May ST,Patel M,Coast GM,Bacon JP

更新日期：1995-01-01 00:00:00

abstract：:Pacifastin-like protease inhibitors belong to a recent classified protease inhibitor family and they are the smallest protease inhibitors described in animals. In this work, we purified and characterized, for the first time, two neutrophil elastase inhibitors belonging to the pacifastin family from the blood sucking i...

journal_title：Peptides

authors： de Marco R,Lovato DV,Torquato RJ,Clara RO,Buarque DS,Tanaka AS

更新日期：2010-07-01 00:00:00

abstract：:Which of Y1-Y5 receptors (Rs) mediate NPY's angiogenic activity was studied using Y2R-null mice and R-specific antagonists. In Y2R-null mice, NPY-induced aortic sprouting and in vivo Matrigel capillary formation were decreased by 50%; Y1R-antagonist blocked the remaining response. NPY-induced sprouting was equally inh...

journal_title：Peptides

authors： Lee EW,Grant DS,Movafagh S,Zukowska Z

更新日期：2003-01-01 00:00:00

abstract：:Leukemia inhibitory factor (LIF) overexpression, induced by the intracerebroventricular (i.c.v.) injection of an recombinant adeno-associated viral vector encoding LIF (rAAV-LIF), resulted in a dose-dependent reduction in body weight (BW) gain, food intake (FI) and adiposity, evidenced by suppression of serum leptin a...

journal_title：Peptides

authors： Beretta E,Dhillon H,Kalra PS,Kalra SP

更新日期：2002-05-01 00:00:00

abstract：:Diapause pupae of the swallowtail butterfly Papilio xuthus L. exhibit diapause-green, orange and brownish-orange color polymorphism. Development of orange pupae involves a neuroendocrine factor inducing orange pupa (Orange-Pupa-Inducing Factor, OPIF), which is secreted from the head-thoracic region during late pharate...

journal_title：Peptides

authors： Yamanaka A,Adachi M,Imai H,Uchiyama T,Inoue M,Islam AT,Kitazawa C,Endo K

更新日期：2006-03-01 00:00:00

abstract：:Angiotensin (Ang)--a peptide that is part of the renin-angiotensin system-induces vasoconstriction and a subsequent increase in blood pressure; Ang peptides, especially AngII, can also act as potent pro-inflammatory mediators. Platelet-activating factor (PAF) is a potent phospholipid mediator that is implicated in man...

journal_title：Peptides

authors： Sato A,Yokoyama I,Ebina K

更新日期：2015-11-01 00:00:00

abstract：:Amylin is a peptide hormone that is mainly known to be produced by pancreatic β-cells in response to a meal but amylin is also produced by brain cells in discrete brain areas albeit in a lesser amount. Amylin receptor (AMY) is composed of the calcitonin core-receptor (CTR) and one of the 3 receptor activity modifying ...

journal_title：Peptides

authors： Boccia L,Gamakharia S,Coester B,Whiting L,Lutz TA,Le Foll C

更新日期：2020-10-01 00:00:00

abstract：:Modification to the structure of glucagon has provided a number of glucagon receptor antagonists with possible therapeutic application for diabetes. These novel peptide analogs include desHis(1)Pro(4)Glu(9)-glucagon and desHis(1)Pro(4)Glu(9)(Lys(30)PAL)-glucagon. This study has evaluated the metabolic benefits of once...

journal_title：Peptides

authors： McShane LM,Franklin ZJ,O'Harte FP,Irwin N

更新日期：2014-10-01 00:00:00

abstract：:We evaluated behavior and cognitive performance in a line of transgenic mice that overexpress the rat gene for vasopressin. Open field testing revealed greatest habituation in homozygous mice. Passive avoidance performance indicated equal learning and memory ability of transgenic compared to normal mice. Drinking beha...

journal_title：Peptides

authors： Miller M,Haroutunian V,Wiltshire-Clement M

更新日期：1995-01-01 00:00:00

abstract：:Spinal cords of rats, cats and monkeys were transected; the animals were perfused at varying times. Other rats were injected with morphine and perfused 10 days later. Immunocytochemistry shows substance P (SP) present in control animals primarily in the substantia gelatinosa (SG) of the dorsal horn of the spinal cord....

journal_title：Peptides

authors： Naftchi NE,Abrahams SJ,St Paul HM,Vacca LL

更新日期：1981-01-01 00:00:00

abstract：:The discovery of several adipokines with diverse activities and their involvement in regulation of various pathophysiological functions of human body has challenged the researchers. In the family of adipokine, chemerin is a novel and unique addition. Ever since the first report on chemerin as a chemo-attractant protei...

journal_title：Peptides

authors： Fatima SS,Rehman R,Baig M,Khan TA

更新日期：2014-12-01 00:00:00

abstract：:A bradykinin (BK)-related peptide was isolated from heat-denaturated plasma from an elasmobranch fish, the little skate, Leucoraja erinacea after incubation with porcine pancreatic kallikrein. The primary structure of the peptide (H-Gly-Ile-Thr-Ser-Trp-Leu-Pro-Phe-OH; skate BK) shows limited structural similarity to t...

journal_title：Peptides

authors： Anderson WG,Leprince J,Conlon JM

更新日期：2008-08-01 00:00:00

abstract：:Despite the high impact of the antimicrobial peptide hepcidin in iron homeostasis, the regulation of this hormone is still not completely understood. Studies concerning hepcidin regulation are performed at the mRNA level. For the first time we analyzed the regulation of hepcidin not only at mRNA, but also at protein l...

journal_title：Peptides

authors： Fein E,Merle U,Ehehalt R,Herrmann T,Kulaksiz H

更新日期：2007-05-01 00:00:00

abstract：:Endokinins are novel tachykinins encoded on the human TAC4 and consist of Endokinin A (EKA), B (EKB), C (EKC) and D (EKD). To date, the function of Endokinins in pain processing was not fully understood. Therefore the aim of this study was to investigate the effects of Endokinin A/B (EKA/B, the common C-terminal decap...

journal_title：Peptides

authors： Yang Y,Dong S

更新日期：2010-01-01 00:00:00

abstract：:The aim of this study was to compare the actions of CCK neuropeptides within the nucleus accumbens (N.Acc) of alcohol preferring (Fawn-Hooded, FH) and alcohol nonpreferring (Wistar-Kyoto, WKY) rats. CCK-8S (30-300 nM) facilitated the K(+) stimulated release of [(3)H]dopamine (DA) from N.Acc prisms in both rat strains,...

journal_title：Peptides

authors： Lodge DJ,Short JL,Mercer LD,Beart PM,Lawrence AJ

更新日期：2000-03-01 00:00:00

abstract：:A novel protease inhibitor, designated mungoin, with both antifungal and antibacterial activities, and exhibiting a molecular mass of 10kDa in SDS-polyacrylamide gel electrophoresis, was isolated from mung bean (Phaseolus mungo) seeds. The isolation procedure involved a combination of extraction, ammonium sulfate prec...

journal_title：Peptides

authors： Wang S,Lin J,Ye M,Ng TB,Rao P,Ye X

更新日期：2006-12-01 00:00:00

abstract：:The functional help provided by four cross-linked synthetic peptides from HIV-1 Gag structural proteins was investigated in the mouse model. These peptides, selected upon non-self-criteria, are not predicted as T epitopes by classical prediction methods such as the Rothbard consensus or the amphipathy rule. Priming mi...

journal_title：Peptides

authors： Benveniste O,Vaslin B,Dormont D

更新日期：1994-01-01 00:00:00

abstract：:As an attempt to approach the pathogenesis of peptic ulcer disease, antral gastrin and somatostatin concentrations were studied in normal subjects, patients with duodenal ulcer and gastric ulcer. In the patients with peptic ulcer, antral somatostatin concentrations were significantly lower than those in normal subject...

journal_title：Peptides

authors： Sumii K,Fukushima T,Hirata K,Matsumoto Y,Sanuki E,Tsumaru S,Sumioka M,Miyoshi A,Miyachi Y

更新日期：1981-01-01 00:00:00

abstract：:Urocortin (Ucn) 1, 2 and 3 are corticotropin-releasing factor (CRF)-related peptides recently characterized in mammals. Urocortin 1 binds with high affinity to CRF type 1 (CRF1) and type 2 (CRF2) receptors while Ucn 2 and Ucn 3 are selective CRF2 ligands. They also have a distinct pattern of distribution, both in the ...

journal_title：Peptides

authors： Martinez V,Wang L,Million M,Rivier J,Taché Y

更新日期：2004-10-01 00:00:00

abstract：:Human Zonulin, related to the Zonula occludens toxin of Vibrio cholerae, regulates intestinal permeability and is induced in inflammatory disorders of the lower GI tract. Gastroesophageal reflux disease (GERD) is associated with an impairment of epithelial barrier function. Here, we studied expression of zonulin in th...

journal_title：Peptides

authors： Wex T,Mönkemüller K,Kuester D,Fry L,Kandulski A,Malfertheiner P

更新日期：2009-06-01 00:00:00

abstract：:Obestatin is a 23-amino-acid peptide originally regarded as an anorexigenic factor. However, most of the subsequent studies failed to confirm the initially reported anorexigenic properties of obestatin. Obestatin is incapable of crossing the blood brain barrier (BBB), which may affect its biological function. Here, we...

journal_title：Peptides

authors： Ren G,He Z,Cong P,Chen H,Guo Y,Yu J,Liu Z,Ji Q,Song Z,Chen Y

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Visfatin is a novel adipokine and proinflammatory cytokine which is implicated in breast cancer progression. The exact proliferative and anti-apoptotic mechanisms of visfatin are still under debate. In this study, the effect of extracellular visfatin on proliferation and apoptosis of breast cancer cells were...

journal_title：Peptides

authors： Gholinejad Z,Kheiripour N,Nourbakhsh M,Ilbeigi D,Behroozfar K,Hesari Z,Golestani A,Shabani M,Einollahi N

更新日期：2017-06-01 00:00:00