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Mechanisms involved in the somatostatin-induced contraction of vascular smooth muscle cells.

Abstract：

:In experimental models and in humans, somatostatin (SRIF) is able to contract certain vascular structures. The present experiments were designed to assess the capacity of SRIF to contract cultured rat aortic vascular smooth muscle cells (VSMC), and to analyze the possible mechanisms involved. Cells incubated with SRIF showed a significant reduction in planar cell surface area, in a time- and dose-dependent manner. This effect was partially blocked by preincubating the cells with a combination of calcium antagonists (10 microM verapamil, plus 10 microM 3,4,5-Trimethoxybenzoic acid 3-(diethylanino) octyl ester TMB)-8). SRIF was also able to stimulate myosin light-chain phosphorylation in VSMC. A small but significant increase of intracellular calcium concentration, and decreased levels of cAMP, without changes in cGMP, were detected in VSMC incubated with SRIF. A search for the known SRIF receptors present in these cells, by reverse transcription-polymerase chain reaction, only SRIF receptor-4 was found to be present. These results demonstrate the ability of SRIF to contract cultured rat VSMC. The contraction observed in these cells appears to be due to a mixed mechanism, that involves [Ca2+]i and cAMP as second messengers, and is likely mediated via SRIF receptor-4.

journal_name

Peptides

journal_title

Peptides

authors

Torrecillas G,Medina J,Díez-Marqués ML,Rodríguez-Puyol D,Rodríguez-Puyol M

doi

10.1016/s0196-9781(99)00083-2

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

929-35

issue

8

eissn

0196-9781

issn

1873-5169

pii

S0196-9781(99)00083-2

journal_volume

20

pub_type

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