Abstract:
:Crude extracts of the marine sponge Geodia corticostylifera from Brazilian Coast have previously shown antibacterial, antifungal, cytotoxic, haemolytic and neurotoxic activities. The present work describes the isolation of the cyclic peptides geodiamolides A, B, H and I (1-4) from G. corticostylifera and their anti-proliferative effects against sea urchin eggs and human breast cancer cell lineages. Its structure-activity relationship is discussed as well. In an initial series of experiments these peptides inhibited the first cleavage of sea urchin eggs (Lytechinus variegatus). Duplication of nuclei without complete egg cell division indicated the mechanism of action might be related to microfilament disruption. Further studies showed that the geodiamolides have anti-proliferative activity against human breast cancer cell lines (T47D and MCF7). Using fluorescence techniques and confocal microscopy, we found evidence that the geodiamolides A, B, H and I act by disorganizing actin filaments of T47D and MCF7 cancer cells, in a way similar to other depsipeptides (such as jaspamide 5 and dolastatins), keeping the normal microtubule organization. Normal cells lines (primary culture human fibroblasts and BRL3A rat liver epithelial cells) were not affected by the treatment as tumor cells were, thus indicating the biomedical potential of these compounds.
journal_name
Peptidesjournal_title
Peptidesauthors
Rangel M,Prado MP,Konno K,Naoki H,Freitas JC,Machado-Santelli GMdoi
10.1016/j.peptides.2006.04.021subject
Has Abstractpub_date
2006-09-01 00:00:00pages
2047-57issue
9eissn
0196-9781issn
1873-5169pii
S0196-9781(06)00194-Xjournal_volume
27pub_type
杂志文章相关文献
PEPTIDES文献大全abstract::Peptides of the adipokinetic hormone (AKH)/red pigment-concentrating hormone (RPCH) family were isolated and sequenced from the retrocerebral corpora cardiaca of four kissing bugs which are all vectors of the protozoan Trypanosoma cruzi responsible for Chagas' disease. The sequence of three novel AKHs were deduced fro...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.09.032
更新日期:2013-03-01 00:00:00
abstract::The aim of this study was to investigate peripheral and central roles of corticotropin-releasing factor (CRF) in endocrinological and behavioral changes. Plasma adrenocorticotropin (ACTH) concentration was measured as an activity of hypothalamic-pituitary-adrenal (HPA) axis. As behavioral changes, locomotion and anxie...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2017.06.009
更新日期:2017-09-01 00:00:00
abstract::The cellular distribution of PP and PYY in mammals is reviewed. Expression of PP is restricted to endocrine cells mainly present in the pancreas predominantly in the duodenal portion (head) but also found in small numbers in the gastro-intestinal tract. PYY has a dual expression in both endocrine cells and neurons. PY...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/s0196-9781(01)00601-5
更新日期:2002-02-01 00:00:00
abstract::The major active product of ghrelin gene is a 28-amino acid peptide acylated at the serine 3 position with an octanoyl group, called simply ghrelin. Ghrelin has a multiplicity of physiological functions, affecting GH release, food intake, energy and glucose homeostasis, gastrointestinal, cardiovascular, pulmonary and ...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2008.02.018
更新日期:2008-07-01 00:00:00
abstract::The effect of synthetic human calcitonin gene-related peptide (hCGRP) on the isolated and electrically driven left atria of rats were investigated. The peptide at concentrations of 3 X 10(-9)-3 X 10(-7) M produced positive inotropic effects on the left atria in a dose-dependent manner. Verapamil (10(-5) M) and adenosi...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(86)90038-0
更新日期:1986-07-01 00:00:00
abstract::Each of the dynorphin A(1-13) or dynorphin (dyn) treatment groups receiving naloxone showed a significant overall reduction of overt signs compared with the dyn controls. The data suggested that the overt psychomotor effects of dyn in the rhesus monkey were especially prone to blockade by naloxone, and probably involv...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(92)90196-a
更新日期:1992-07-01 00:00:00
abstract::In the present study, we present for the first time the presence and distribution of neuropeptide Y (NPY) receptors Y1 and Y2 in the human postmortem heart using specific antibodies raised against extracellular parts of the receptors. A more intensive staining against the Y2 than against the Y1 receptors was detected ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(03)00041-x
更新日期:2003-02-01 00:00:00
abstract::The role of the D-Trp residues in the sequence of the NK2-selective tachykinin antagonist, MEN 10207 (Asp-Tyr-D-Trp-Val-D-Trp-D-Trp-Arg-NH2). has been examined by replacement of each D-Trp with either the L-isomer or the residue naturally occurring in the same position of neurokinin A(4-10). The biological activity of...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(91)90053-r
更新日期:1991-09-01 00:00:00
abstract::This study presents the binding and functional properties of the mouse NPFF(2) (mNPFF(2)) receptor, in comparison with its human counterpart (hNPFF(2)). Binding experiments were performed by using the NPFF(2) selective radioligand [(3)H]-EYF in membranes from CHO cells transfected with mouse and human NPFF(2) receptor...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2009.11.020
更新日期:2010-02-01 00:00:00
abstract::The ability of acute exercise to stimulate appetite and food intake depends on intensity, duration, and agouti-related protein (AGRP) levels. Fasting, as well as any negative energy balance, has been reported to increase AGRP expression in the arcuate nucleus (ARC) of the hypothalamus and other extra-hypothalamic tiss...
journal_title:Peptides
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.peptides.2007.02.004
更新日期:2007-05-01 00:00:00
abstract::The objective of this study was to explore the effects of the endogenous opioid peptide dynorphin A(1-13) on the CNS regulation of blood pressure and heart rate. Wistar rats, anesthetized with pentobarbital and halothane, received dynorphin A(1-13) microinjected into the anterior hypothalamus area (AHA), the posterior...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(93)90184-i
更新日期:1993-11-01 00:00:00
abstract::The presence of a putative GRP receptor on rat pancreatic particulate membranes was demonstrated by covalent cross-linking to 125I-gastrin releasing peptide (GRP), which revealed a radioactive band with Mr = 80-90 kDa on reduced SDS-PAGE. Fresh rat pancreatic membranes contained a GRP receptor which was solubilized wi...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(91)90001-6
更新日期:1991-03-01 00:00:00
abstract::The Manduca allatotropin (Mas-AT) gene is expressed as at least three mRNA isoforms that differ from each other by alternative splicing. The location at which the alternative exons are included in the mature mRNAs occur within the open reading frame, so that three different propeptides are predicted as translation pro...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(00)00378-8
更新日期:2001-02-01 00:00:00
abstract::Cholecystokinin (CCK) and met-enkephalin (MEK) related peptides have been shown to alter feeding behavior subsequent to their injection into the peripheral circulation or directly into the brains of several species. To evaluate the potential role of endogenous brain pools of these peptides in feeding, groups of sheep ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(85)90325-0
更新日期:1985-09-01 00:00:00
abstract::Investigators studying the primary culprit responsible for Alzheimer disease have, for the past two decades, primarily focused on amyloid-beta (Abeta). Here, we put Abeta on trial and review evidence amassed by the prosecution that implicate Abeta and also consider arguments and evidence gathered by the defense team w...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/s0196-9781(02)00069-4
更新日期:2002-07-01 00:00:00
abstract::Somatostatin has been proposed as a regulatory peptide of nutrient entry and fuel homeostasis because of its ability to inhibit the release of substances involved in food digestion and metabolism. The aim of the study was to evaluate the somatostatin response to a test meal in type I diabetics at the clinical onset of...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(86)90204-4
更新日期:1986-01-01 00:00:00
abstract::Peptides may act through G protein-coupled receptors to influence cardiovascular performance; thus, delineating mechanisms involved in signaling is a molecular-based strategy to influence health. Molecular switches, often represented by conserved motifs, maintain a receptor in an inactive state. However, once the swit...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2015.07.012
更新日期:2015-09-01 00:00:00
abstract::beta-Lactotensin (beta-LT) is a bioactive peptide derived from bovine milk beta-lactoglobulin and is a natural ligand for neurotensin receptors. We examined the effect of beta-LT on restraint stress and fear memory in mice. Mice subjected to acute restraint stress exhibited a decreased number of head-dips and increase...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2006.08.009
更新日期:2006-12-01 00:00:00
abstract::Bilateral electrolytic lesions of caudate nucleus were observed to potentiate the cataleptic response, and to prevent the muscular rigidity produced by intracerebroventricular injection or infusion of dermorphin. These results suggest that caudate nucleus plays an inhibitory role in controlling the cataleptic response...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(85)90368-7
更新日期:1985-01-01 00:00:00
abstract::Amphibians exhibit various, characteristic adaptations related to their "incomplete" shift from the aquatic to the terrestrial habitat. In particular, the integument was subject to a number of specialized modifications during the evolution of these animals. In this review, we place special emphasis on endogenous host-...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2014.11.003
更新日期:2015-01-01 00:00:00
abstract::The hypothalamic neuropeptide orexin A (hypocretin-1) is a key signal in sleep/wake regulation and promotes food intake. We investigated the relationship between cerebrospinal fluid orexin A concentrations and body composition in non-narcoleptic human subjects with a wide range of body weight to gain insight into the ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2018.02.005
更新日期:2018-04-01 00:00:00
abstract::We have attempted to demonstrate a pancreatic secretory response to intraduodenal amino acids in the anesthetized cat. In four cats stimulated with supramaximal doses of secretin, protein concentrations in pancreatic juice were measured after intraduodenal bolus injection of various amino acids, IV CCK, or electrical ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(82)90040-7
更新日期:1982-03-01 00:00:00
abstract::The elevated T-maze was combined with a free exploration protocol, which, in contrast to the conventional procedure, dispenses with handling of the animals during the experimental sessions. This allows measurement of fear indexes derived from the elevated plus-maze as well as assessment of acquisition of open arm avoi...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(01)00421-1
更新日期:2001-07-01 00:00:00
abstract::Neurotensin (NT) produces behavioral and physiological effects, including analgesia and hypotheria, when administered into the CNS. Fischer and Lewis rats exhibit differential behavioral responses to central NT receptor activation. To further characterize these differences, we assessed central NT-induced analgesia and...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2003.06.004
更新日期:2003-08-01 00:00:00
abstract::Circulating urotensin II (UII) concentrations and the tissue expression of its cognate receptor (UT) are elevated in patients with cardiovascular disease (CVD). The functional significance of elevated plasma UII levels in CVD is unclear. Urotensin-related peptide (URP) is a paralog of UII in that it contains the six a...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2007.08.013
更新日期:2008-05-01 00:00:00
abstract::The neuroendocrine and behavioral effects of Tyr-D-Ala-Gly-Phe-D-Nle-Arg-Phe (DADN), a more stable derivative of the endogenous opiate Met-enkephalin related peptide Met(5)-enkephalin-Arg(6)-Phe(7) were investigated in mice. The behavioral experiments consisted of monitoring the horizontal (square crossing) and vertic...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2011.05.029
更新日期:2011-08-01 00:00:00
abstract::The effect of melanin-concentrating hormone (MCH) on the release of alpha-melanocyte stimulating hormone (alpha-MSH) from the tilapia pituitary gland was studied in vitro. In a superfusion set up, 10 nM to 1 microM synthetic salmon MCH caused a concentration-dependent inhibition of alpha-MSH release from tilapia neuro...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(95)00063-p
更新日期:1995-01-01 00:00:00
abstract::We studied the expression of the osteogenic and antinociceptive C-terminal histone H4-related peptide fragments, H4-(89-102) (OGP) and H4-(86-100), respectively, within various rat tissues and isolated alveolar macrophages (AM) by radioimmunoassay (RIA). OGP was located mainly within the bone marrow, spleen, thymus, a...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2005.03.013
更新日期:2005-08-01 00:00:00
abstract::Previous studies have shown that the nervous system and other tissues of molluscs contain a number of peptides that potently excite molluscan hearts. Two such peptides, termed small cardioactive peptides A and B (SCPA and SCPB) are present in large quantities in the nervous system of Aplysia. These peptides are widely...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(87)90184-7
更新日期:1987-01-01 00:00:00
abstract::The present status of our understanding of the feedback regulation of pancreatic secretion by peptide YY (PYY) released from the distal intestine is reviewed. Exocrine pancreatic secretion is primarily controlled by the cephalic (the vagus nerve), gastric (acid and pepsin secretion, and nutrients delivered into the du...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/s0196-9781(01)00612-x
更新日期:2002-02-01 00:00:00