Abstract：
:The effect of peripheral injections of substance P (SP) on performance in two different configurations of an automated tunnel maze was examined in three experiments. In two experiments, the effect of pretrial SP injections (10-1000 micrograms/kg) on performance in the hexagonal and radial maze configuration of an automated tunnel maze was investigated. In the hexagonal maze, which measures activity, exploratory efficiency, habituation, and perimeter walking, injection of SP affected perimeter walking only. In the radial maze, SP produced a facilitation of measures of efficiency and long-term and short-term memory without affecting activity. In the third experiment, the effect of pre- and posttrial injections of SP (50 or 500 micrograms/kg) on performance in the radial maze configuration was tested. Again, pretrial injections of 500 micrograms of SP facilitated performance with respect to measures of efficiency and short- and long-term memory; 50 micrograms produced a weaker effect. Virtually no effect was seen with posttrial injections.
journal_name
Peptidesjournal_title
Peptidesauthors
Nagel JA,Welzl H,Bättig K,Huston JPdoi
10.1016/0196-9781(93)90014-8subject
Has Abstractpub_date
1993-01-01 00:00:00pages
85-95issue
1eissn
0196-9781issn
1873-5169pii
0196-9781(93)90014-8journal_volume
14pub_type
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