The Mycobacterium tuberculosis membrane protein Rv0180c: Evaluation of peptide sequences implicated in mycobacterial invasion of two human cell lines.

abstract：:As we commemorate the 25th anniversary of the journal Peptides, it is timely to review the functional significance of the bombesin (BB)-like peptides and receptors in the CNS. Over two decades ago we published an article in the journal Peptides demonstrating that BB-like peptides are present in high densities in certa...

journal_title：Peptides

authors： Moody TW,Merali Z

更新日期：2004-03-01 00:00:00

abstract：:Neuropeptide Y (NPY) induces feeding in previously satiated animals after injection into the hypothalamus, especially the perifornical region (PFH). NPY also appears to have rewarding properties as evidenced by its ability to produce a conditioned place preference following injection into the nucleus accumbens (N.Acc)...

journal_title：Peptides

authors： Brown CM,Fletcher PJ,Coscina DV

更新日期：1998-01-01 00:00:00

abstract：:Pacifastin-like protease inhibitors belong to a recent classified protease inhibitor family and they are the smallest protease inhibitors described in animals. In this work, we purified and characterized, for the first time, two neutrophil elastase inhibitors belonging to the pacifastin family from the blood sucking i...

journal_title：Peptides

authors： de Marco R,Lovato DV,Torquato RJ,Clara RO,Buarque DS,Tanaka AS

更新日期：2010-07-01 00:00:00

abstract：:Age-related changes in NPY-driven angiogenesis were investigated using Matrigel and aortic sprouting assays in young (2 months.) and aged (18 months.) mice. In both assays, NPY-induced vessel growth decreased significantly with age. In parallel, aged mice showed reduced expression (RT-PCR) of Y2 receptors and the NPY ...

journal_title：Peptides

authors： Kitlinska J,Lee EW,Movafagh S,Pons J,Zukowska Z

更新日期：2002-01-01 00:00:00

abstract：:The monoclonal antibody 2F5 recognizing the neutralizing epitope ELDKWA on the C-domain could neutralize 90% of the investigated HIV-1 isolates. Low levels of ELDKWA-epitope-specific antibodies were observed in HIV-1-infected individuals. To induce high levels of antibodies to ELDKW-epitope, C-domain peptide (P2) was ...

journal_title：Peptides

authors： Liao M,Lu Y,Xiao Y,Dierich MP,Chen Y

更新日期：2000-04-01 00:00:00

abstract：:A novel peptide, de7b, was isolated from the venom of Conus delessertii, a worm-hunting species collected in the Caribbean Sea off the Yucatan Peninsula. Its primary structure was determined by automated Edman degradation and confirmed by mass spectrometry: it contains 28 amino acids, including six Cys residues. Pepti...

journal_title：Peptides

authors： Aguilar MB,Flores-Torres A,Batista CV,Falcón A,López-Vera E,de la Cotera EP

更新日期：2009-03-01 00:00:00

abstract：:Structurally unique, synthetic prion peptides provide the basis of a simple assay to serve as both a detection and signal amplification system that distinguishes the normal prion protein, PrPC, from the misfolded prion protein, PrPSc, that is associated with the occurrence of transmissible spongiform encephalopathies ...

journal_title：Peptides

authors： Grosset A,Moskowitz K,Nelsen C,Pan T,Davidson E,Orser CS

更新日期：2005-11-01 00:00:00

abstract：:In this study we investigated the role that dopaminergic pathways play in the miotic effect exerted by neurotensin after intracameral administration. Neurotensin was injected into the anterior chamber (AC) at a dose of 30 micrograms to 4 groups of albino rabbits which had previously undergone the following treatment: ...

journal_title：Peptides

authors： Tassorelli C,Spampinato D,Caruso P,Cavaliere S,Micieli G,Drago F,Nappi G

更新日期：1990-11-01 00:00:00

abstract：:Two peptides, with a molecular mass of about 11 kDa and an N-terminal sequence abundant in arginine and glutamine residues, were isolated from wax gourd seeds. The isolation protocol included affinity chromatography on Affi-gel blue gel, ion-exchange chromatography on Mono-S and gel filtration on Superdex 75. The pept...

journal_title：Peptides

authors： Ng TB,Parkash A,Tso WW

更新日期：2003-01-01 00:00:00

abstract：:There is growing evidence of the antimicrobial properties of histones and histone-derived peptides; however, most of them are specific to lysine (Lys)-rich histones (H1, H2A, and H2B). In the present study, we focused on arginine (Arg)-rich histones (H3 and H4) and investigated their antimicrobial properties in compar...

journal_title：Peptides

authors： Tagai C,Morita S,Shiraishi T,Miyaji K,Iwamuro S

更新日期：2011-10-01 00:00:00

abstract：:Trefoil factors (TFFs) 1, 2 and 3 are small polypeptides that are co-secreted with mucin throughout the body. They are up-regulated in cancer and inflammatory processes in the gastrointestinal system, where they are proposed to be involved in tissue regeneration, proliferation and protection. Our aim was to explore th...

journal_title：Peptides

authors： Viby NE,Nexø E,Kissow H,Andreassen H,Clementsen P,Thim L,Poulsen SS

更新日期：2015-01-01 00:00:00

abstract：:Gastric inhibitory polypeptide (GIP) is a 42 amino acid hormone secreted from intestinal K-cells in response to nutrient ingestion. Despite a recognised physiological role for GIP as an insulin secretagogue to control postprandial blood glucose levels, growing evidence reveals important actions of GIP on adipocytes an...

journal_title：Peptides

authors： Irwin N,Gault VA,O'Harte FPM,Flatt PR

更新日期：2020-03-01 00:00:00

abstract：:The objective of this study was to investigate absorption enhancing approaches for systemic delivery of methionine enkephalin via the nose. Absorption promotion of methionine enkephalin in the presence of protease inhibitors (bestatin, puromycin) and absorption enhancers (glycocholate, dimethyl-beta-cyclodextrin) were...

journal_title：Peptides

authors： Agu RU,Vu Dang H,Jorissen M,Kinget R,Verbeke N

更新日期：2004-04-01 00:00:00

abstract：:The intestinal enzymatic degradation of the immunomodulating peptides thymotrinan (TP3), thymocartin (TP4), and thymopentin (TP5), three oligopeptides derived from the naturally occurring thymus hormone thymopoietin, was investigated to evaluate their potential for peroral drug delivery. In the presence of brush-borde...

journal_title：Peptides

authors： Heizmann J,Langguth P,Biber A,Oschmann R,Merkle HP,Wolffram S

更新日期：1996-01-01 00:00:00

abstract：:Somatostatin-14 (S14) and its precursor, somatostatin-28 (S28), are widely distributed throughout the rat brain, suggesting that they could act as neurotransmitter or neuromodulator in the central nervous system. The present study was undertaken to study the localization of S14 and S28 receptors in the rat brain deter...

journal_title：Peptides

authors： Leroux P,Pelletier G

更新日期：1984-05-01 00:00:00

abstract：:In this study we examined the effects of 2% saline loading (S), partial restriction of water consumption (R) or a combination of S or R with dexamethasone (DEX) treatment for 14 days on corticotropin releasing factor (CRF)-41 content of the neurointermediate lobe (NIL) and supraoptic nuclei (SON) of male Wistar rats. ...

journal_title：Peptides

authors： Dohanics J,Linton EA,Lowry PJ,Makara GB

更新日期：1990-01-01 00:00:00

abstract：:The binding activity of several galanin fragments and analogs was measured on specific receptors present in rat brain and the rat pancreatic beta cell line Rin m 5F. In both tissues it was observed that: 1) galanin(3-29), galanin(10-29) and [Ile2]-galanin were ineffective for inhibiting [125I] galanin binding and 2) a...

journal_title：Peptides

authors： Lagny-Pourmir I,Lorinet AM,Yanaihara N,Laburthe M

更新日期：1989-07-01 00:00:00

abstract：:The present study sought to examine the mechanism of substance P to modulate the antinociceptive action of intrathecal (i.t.) morphine in paw-licking/biting response evoked by subcutaneous injection of capsaicin into the plantar surface of the hindpaw in mice. The i.t. injection of morphine inhibited capsaicin-induced...

journal_title：Peptides

authors： Komatsu T,Sasaki M,Sanai K,Kuwahata H,Sakurada C,Tsuzuki M,Iwata Y,Sakurada S,Sakurada T

更新日期：2009-09-01 00:00:00

abstract：:The guinea pig ileum possesses NK-1 and NK-3 tachykinin receptors. As expected, [Pro9]SP and senktide, which are selective agonists of NK-1 and NK-3 receptors, respectively, were found to be highly potent in contracting the guinea pig ileum. Surprisingly, similar observations were made with septide, SP-O-CH3, [Apa9-10...

journal_title：Peptides

authors： Petitet F,Saffroy M,Torrens Y,Lavielle S,Chassaing G,Loeuillet D,Glowinski J,Beaujouan JC

更新日期：1992-03-01 00:00:00

abstract：:Experiments characterized the behavioral effects of bombesin (BN) administered systemically (1-8 micrograms/kg; IP) or centrally at the nucleus tractus solitarius (NTS) and the nucleus accumbens (NA) (0.0001-1.0 microgram/0.5 microliter). The role of dopaminergic system(s) in the mediation of BN-induced behavioral eff...

journal_title：Peptides

authors： Johnston SA,Merali Z

更新日期：1988-01-01 00:00:00

abstract：:The cross-immunoreactivity, topography, and fiber projections of the alpha MSH-immunoreactive specific neurons in the forebrain of the rat appear to be distinctly different from that of the neurons in the hypothalamic arcuate opiocortin system. The cell bodies, immunoreactive only to alpha-MSH, have a specific pattern...

journal_title：Peptides

authors： Piekut DT,Knigge KM

更新日期：1984-11-01 00:00:00

abstract：:Neurotensin and somatostatin have both been shown to inhibit gastric acid secretion, but no interaction between these peptides has been demonstrated. To determine whether somatostatin might be a mediator of neurotensin's effect on pentagastrin-stimulated gastric acid secretion, we performed the following three experim...

journal_title：Peptides

authors： Hammer RA,Ochoa A,Fernandez C,Ertan A,Arimura A

更新日期：1992-11-01 00:00:00

abstract：:For clinical use, it is essential to develop potent endomorphin (EM) analogs with reduced antinociceptive tolerance. In the present study, the antinociceptive activities and tolerance development of four potent EM-1 analogs with C-terminal oligoarginine-conjugation was evaluated and compared in the radiant heat paw wi...

journal_title：Peptides

authors： Yuan BY,Liu WZ,Wang XF,Zhang YZ,Yang DJ,Wang CL

更新日期：2018-08-01 00:00:00

abstract：:Recently two hypothalamic releasing factors have been isolated, sequenced and synthesized: corticotropin-releasing factor (CRF) from sheep and rat hypothalami; and growth hormone-releasing factor (GH-RF) from tumors in human pancreas (hpGH-RF) and from rat hypothalami (rhGH-RF). Their biological potencies were tested ...

journal_title：Peptides

authors： Vigh S,Schally AV

更新日期：1984-01-01 00:00:00

abstract：:Studies on the in vitro interaction of beta-endorphin with different biomembrane preparations, measured in terms of Ca2+ induced chlorotetracycline (CTC) fluorescence alterations indicate that beta-endorphin causes release of calcium ion from both synaptosomal and erythrocyte membrane stores but not from rat brain mit...

journal_title：Peptides

authors： Chakrabarti AK,Chatterjee TK,Ghosh JJ

更新日期：1983-05-01 00:00:00

abstract：:Intracerebroventricular (ICV) and subcutaneous (SC) injections of sauvagine powerfully inhibited gastric acid secretion stimulated by gastric distension and by 2-deoxy-D-glucose, but not by histamine in pylorus-ligated rats. Naloxone failed to antagonize the antisecretory effects of SC and ICV sauvagine. Intravenous i...

journal_title：Peptides

authors： Improta G,Broccardo M

更新日期：1988-07-01 00:00:00

abstract：:Rhesus monkey MCH-R1 and MCH-R2 receptors were cloned. Amino acid homology is 98.8% between monkey and human MCH-R1, while monkey and human MCH-R2 are 98% homologous. Binding and intracellular signaling characteristics of the monkey receptors were compared with the human homologues. The results demonstrate that MCH bi...

journal_title：Peptides

authors： Fried S,O'Neill K,Hawes BE

更新日期：2002-08-01 00:00:00

abstract：:Central nervous systems of the pond snail Lymnaea stagnalis were incubated in vitro in different concentrations of ORG 2766 (10(-9)-2.5 x 10(-4) M) for 10 and 20 h. Quantitative ultrastructural study of cross sections of the cerebral commissure showed that the number of microtubules in large axons had increased after ...

journal_title：Peptides

authors： Müller LJ,Moorer-van Delft CM,Boer HH

更新日期：1992-07-01 00:00:00

abstract：:Endothelin-1 may contribute to bronchial smooth muscle constriction and airway remodelling in asthma, where bronchial epithelial cells represent an important source of this peptide. We report here that asthmatic bronchial epithelial cells exposed to allergens in vitro induce the differentiation of airway fibroblasts i...

journal_title：Peptides

authors： Sun G,Stacey MA,Bellini A,Marini M,Mattoli S

更新日期：1997-01-01 00:00:00

abstract：:The synthesis is described of an analogue of the locust CRF-like diuretic peptide in which methionine in positions 1,3, and 13 is replaced by isosteric methyl-homoserine residues. This analogue has been tested for biological activity on Malpighian tubules in vitro, and feeding behavior in vivo. It is highly active in ...

journal_title：Peptides

authors： Goldsworthy GJ,Chung JS,Simmonds MS,Tatari M,Varouni S,Poulos CP

更新日期：2003-10-01 00:00:00