Abstract：
:Immunoreactive alpha-MSH was found in human skin and the skin of numerous other mammals. After hypophysectomy the concentration of alpha-MSH in rat skin showed little change suggesting that the pituitary is not the source of this MSH. In human skin the highest concentration was found in the epidermis and HPLC revealed four peaks of immunoreactive alpha-MSH. Two of these co-eluted with mono- and des-acetyl alpha-MSH standards. An earlier peak probably represented an oxidized MSH and a later running peak, diacetylated alpha-MSH. Although no differences were found in alpha-MSH content of skin from albino and pigmented rats or between involved and non-involved epidermis of patients with vitiligo, its predominance in human epidermis could suggest a relationship with the melanocyte or its melanin. Whether alpha-MSH in the skin has any pigmentary significance or any other role has yet to be established.
journal_name
Peptidesjournal_title
Peptidesauthors
Thody AJ,Ridley K,Penny RJ,Chalmers R,Fisher C,Shuster Sdoi
10.1016/0196-9781(83)90072-4subject
Has Abstractpub_date
1983-11-01 00:00:00pages
813-6issue
6eissn
0196-9781issn
1873-5169pii
0196-9781(83)90072-4journal_volume
4pub_type
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