Abstract:
:Numerous works associate the MCH peptide, and the hypothalamic neurons that produce it, to the feeding behavior and energy homeostasis. It is commonly admitted that MCH is an orexigenic peptide, and MCH neurons could be under the control of arcuate NPY and POMC neurons. However, the literature data is not always concordant. In particular questions about the intrahypothalamic circuit involving other neuropeptides and about the mechanisms through which MCH could act are not yet clearly answered. For example, which receptors mediate a MCH response to NPY or alpha-MSH, does MCH act alone, is there any local anatomical organization within the tuberal LHA? A review of the current literature is then needed to help focus attention on these unresolved and often neglected issues.
journal_name
Peptidesjournal_title
Peptidesauthors
Griffond B,Risold PYdoi
10.1016/j.peptides.2009.07.008subject
Has Abstractpub_date
2009-11-01 00:00:00pages
2045-51issue
11eissn
0196-9781issn
1873-5169pii
S0196-9781(09)00279-4journal_volume
30pub_type
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