Abstract:
:La Crosse (LAC) virions exposed to different pHs (7.3, 6.2, and 5.4) and temperatures (37 degrees, 20 degrees, and 4 degrees) were preserved in thin layers of vitreous ice and observed by electron cryomicroscopy. Our results indicate that, at lower pH, virus particles interact with each other to form aggregates. In some cases, particles could be interpreted to have fused together. At neutral pH and higher temperatures morphological changes consistent with deformation in some particles were observed. We suggest that low pH conditions are sufficient for membrane fusion events to occur with LAC virions.
journal_name
Virologyjournal_title
Virologyauthors
Wang GJ,Hewlett M,Chiu Wdoi
10.1016/0042-6822(91)90869-dsubject
Has Abstractpub_date
1991-09-01 00:00:00pages
455-9issue
1eissn
0042-6822issn
1096-0341journal_volume
184pub_type
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