Abstract:
:Thirteen temperature-sensitive (ts) mutants of human cytomegalovirus (HCMV) have been isolated after mutagenesis with nitrosoguanidine or ultraviolet light. Four mutants defective in viral DNA synthesis at nonpermissive temperature (DNA-) were classified into two separate complementation groups. The other nine HCMV ts mutants, capable of synthesizing viral DNA at the elevated temperature (DNA+), belonged to seven independent complementation groups. The number of essential genes encoded by HCMV is thus raised here by nine.
journal_name
Virologyjournal_title
Virologyauthors
Dion M,Hamelin Cdoi
10.1016/0042-6822(87)90257-1subject
Has Abstractpub_date
1987-05-01 00:00:00pages
228-30issue
1eissn
0042-6822issn
1096-0341journal_volume
158pub_type
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