Abstract：
:Cancer cachexia is a complex and multifactorial syndrome that influences about 50-80% of cancer patients and may lead to 20% of cancer deaths and muscle atrophy is the key characteristic of the syndrome. Recent researches have shown that myostatin is a negative regulator in the growth and differentiation of skeletal muscle. Herein, C2C12 cancer cachexia model was established with C26 conditioned culture medium (CCM), then treated with magnolol to evaluate the pharmacological activity of magnolol in myotube atrophy. Our results demonstrated that magnolol inhibited the activity of myostatin promotor and the myostatin signaling pathway. In C2C12 cancer cachexia model, magnolol decreased myostatin expression, inhibited the phosphorylation of SMAD2/3 activated by C26 conditioned culture medium (CCM), and elevated the phosphorylation of FOXO3a lowered by CCM. Myosin heavy chain (MyHC), myogenin (MyoG), and myogenic differentiation (MyoD), as three common myotube markers in C2C12 myotube, were decreased by CCM, which could be effectively reversed by magnolol via activation of AKT/mTOR-regulated protein synthesis and inhibition of ubiquitin-mediated proteolysis. This study reveals that magnolol inhibits myotube atrophy induced by CCM by increasing protein synthesis and decreasing ubiquitin-mediated proteolysis, so that magnolol is a promising leading compound in treating muscle atrophy induced by cancer cachexia.
journal_name
J Nat Medjournal_title
Journal of natural medicinesauthors
Ge Z,Liu D,Shang Y,Li Y,Chen SZdoi
10.1007/s11418-020-01428-3subject
Has Abstractpub_date
2020-09-01 00:00:00pages
741-749issue
4eissn
1340-3443issn
1861-0293pii
10.1007/s11418-020-01428-3journal_volume
74pub_type
杂志文章abstract：:Agarwood oil and spikenard extract were examined for their sedative activity using a spontaneous vapor administration system. It was shown that inhalation of agarwood oil vapor sedated mice. The main volatile constituents of the oil were found to be benzylacetone [agarwood oil from a Hong Kong market (1)], or alpha-gu...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-007-0177-0
更新日期：2008-01-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-008-0261-0
更新日期：2008-10-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-012-0668-5
更新日期：2013-01-01 00:00:00
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journal_title：Journal of natural medicines
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doi：10.1007/s11418-018-1175-0
更新日期：2018-03-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-007-0224-x
更新日期：2008-04-01 00:00:00
abstract：:Acanthopanax senticosus HARMS (AS) is used as a Chinese herbal medicine and as a health supplement in Japan. However, little is known about the interaction between AS and other drugs. In this study, we investigated the effect of AS extract on intestinal drug transporter (P-glycoprotein, or P-gp) and peptide transporte...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-009-0371-3
更新日期：2010-01-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-015-0956-y
更新日期：2016-07-01 00:00:00
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journal_title：Journal of natural medicines
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doi：10.1007/s11418-016-1051-8
更新日期：2017-01-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-010-0429-2
更新日期：2010-10-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-018-1231-9
更新日期：2019-01-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-016-0984-2
更新日期：2016-07-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-012-0707-2
更新日期：2013-07-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-019-01376-7
更新日期：2020-03-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-010-0464-z
更新日期：2011-01-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-019-01307-6
更新日期：2019-06-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-015-0933-5
更新日期：2016-01-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-009-0338-4
更新日期：2009-07-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-012-0677-4
更新日期：2013-04-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
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更新日期：2016-10-01 00:00:00
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journal_title：Journal of natural medicines
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更新日期：2011-07-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-011-0612-0
更新日期：2012-07-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
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更新日期：2014-07-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-015-0926-4
更新日期：2015-10-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-019-01334-3
更新日期：2020-01-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-010-0409-6
更新日期：2010-07-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-017-1119-0
更新日期：2018-01-01 00:00:00
abstract：:Eurycomanone, an active constituent isolated from Eurycoma longifolia Jack, was examined for modulatory effects on cytochrome P450 (CYP) isoforms CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2C19, CYP2E1 and CYP3A4 using in vitro assays. The IC50 value was determined to assess the potencies of modulation for each CYP isoform. O...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-013-0794-8
更新日期：2014-04-01 00:00:00
abstract：:We have previously shown that the two sesquiterpene lactones, salograviolide A (Sal A) and iso-seco-tanapartholide (TNP), isolated from the Middle Eastern indigenous plants Centaurea ainetensis and Achillea falcata, respectively, possess selective antitumor properties. Here, we aimed to assess the anticancer effects o...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-012-0703-6
更新日期：2013-07-01 00:00:00
abstract：:The hypolipidemic activity of Symplocos cochinchinensis S. Moore leaves was studied in Triton WR-1339- and high fat diet-induced hyperlipidemic rats. In Triton WR-1339-induced hyperlipidemic rats, the hexane extract (250 and 500 mg/kg) exerted a significant (P < 0.01) lipid-lowering effect compared to ethyl acetate an...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-011-0548-4
更新日期：2012-01-01 00:00:00
abstract：:In our previous study, piperlonguminine from the fruit of Piper chaba was reported to promote adipogenesis in 3T3-L1 cells like the peroxisome proliferator-activated receptor-γ (PPARγ) agonist, troglitazone. In the present study, the mode of action of piperlonguminine in cells was examined. Piperlonguminine increased ...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-013-0770-3
更新日期：2014-01-01 00:00:00
