当前位置： SCI文献检索 > Journal of Natural Medicines期刊下所有文献 > Anti-oxidative, anti-secretory and anti-inflammatory activities of the extract from the root bark of Lycium chinense (Cortex Lycii) against gastric ulcer in mice.

Anti-oxidative, anti-secretory and anti-inflammatory activities of the extract from the root bark of Lycium chinense (Cortex Lycii) against gastric ulcer in mice.

Abstract：

:The evaluation of the antioxidant, anti-secretory and anti-inflammatory potentials of the ethyl acetate fraction (ELC) from the root bark of Lycium chinense against ethanol-induced gastric ulcer in mice and the possible mechanisms underlying this action was performed. The results indicated that oral administration of ELC (50, 100, 200 and 400 mg/kg) before ethanol-induced ulcer increased the gastric mucus content, restored the superoxide dismutase and glutathione levels, reduced malondialdehyde levels and inhibited the activity of myeloperoxidase. Furthermore, ELC displayed its anti-secretory activity by decreasing the gastric juice and increased the gastric pH and reduced pro-inflammatory markers and caspase-3 tissue levels. These results suggest that L. chinense displays gastroprotective properties as a result of its antioxidant, anti-inflammatory, anti-secretory and anti-apoptotic effects.

journal_name

J Nat Med

journal_title

Journal of natural medicines

authors

Chen H,Olatunji OJ,Zhou Y

doi

10.1007/s11418-016-0984-2

subject

Has Abstract

pub_date

2016-07-01 00:00:00

pages

610-9

issue

3

eissn

1340-3443

issn

1861-0293

pii

10.1007/s11418-016-0984-2

journal_volume

70

pub_type

杂志文章

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