Abstract:
:Rhamnan sulfate (RS) is a polysaccharide with a rhamnose backbone isolated from Monostroma nitidum. Like heparin, it exerts anticoagulant activity in the presence of antithrombin. Endothelial cells facilitate the crosstalk between blood coagulation and vascular inflammation. In this study, we compared the effect of RS with that of heparin on blood coagulation and vascular endothelial cells in the presence or absence of inflammatory factors, using human umbilical vein endothelial cells. We found that RS significantly enhances inhibition of thrombin and factor Xa in the presence of antithrombin as well as heparin, and that RS inhibits tissue factor expression and von Willebrand factor release from the endothelial cells treated with or without lipopolysaccharide, tumor necrosis factor-α, or thrombin. Heparin did not show any effects on endothelial cell inflammation. Our findings suggest that RS, like heparin, is an antithrombin-dependent anticoagulant and, unlike heparin, is a potent anti-inflammatory agent acting on vascular endothelial cells.
journal_name
J Nat Medjournal_title
Journal of natural medicinesauthors
Okamoto T,Akita N,Terasawa M,Hayashi T,Suzuki Kdoi
10.1007/s11418-019-01289-5subject
Has Abstractpub_date
2019-06-01 00:00:00pages
614-619issue
3eissn
1340-3443issn
1861-0293pii
10.1007/s11418-019-01289-5journal_volume
73pub_type
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journal_title:Journal of natural medicines
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