Abstract:
:Phytochemical investigation of the methanol extract of Vitex limonifolia leaves led to the isolation of three new labdane-type diterpenoids, vitexlimolides A-C (1-3) and eight known compounds, 5,4'-dihydroxy-3,7-dimethoxyflavone (4), vitecetin (5), 5,4'-dihydroxy-7,3'-dimethoxyflavone (6), verrucosin (7), 2α, 3α-dihydroxy-urs-12-en-28-oic acid (8), euscaphlic acid (9), 18,19-seco, 2α, 3α-dihydroxy-19-oxo-urs-11,13(18)-dien-28-oic acid (10), and maslinic acid (11). Their chemical structures were elucidated by physical and chemical methods. All compounds were evaluated for antiviral activities against CVB3, HRV1B, and EV71 viruses. As a result, compounds 4 and 6 showed potent antiviral activity against CVB3 infection with IC50 values of 0.12 ± 0.06 and 1.86 ± 0.18 (µM), respectively.
journal_name
J Nat Medjournal_title
Journal of natural medicinesauthors
Ban NK,Thoa NTK,Linh TM,Trang DT,Van Kiem P,Nhiem NX,Tai BH,Van Minh C,Song JH,Ko HJ,Kim SHdoi
10.1007/s11418-017-1125-2subject
Has Abstractpub_date
2018-01-01 00:00:00pages
290-297issue
1eissn
1340-3443issn
1861-0293pii
10.1007/s11418-017-1125-2journal_volume
72pub_type
杂志文章abstract::A new indole alkaloid, leucoridine A N-oxide (1), consisting of two units of a strychnan type of skeleton, was isolated from the leaves of Leuconotis griffithii. Its structure was elucidated by various spectroscopic means such as NMR and MS, and also by chemical means. Antiplasmodial activity against Plasmodium falcip...
journal_title:Journal of natural medicines
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journal_title:Journal of natural medicines
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journal_title:Journal of natural medicines
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journal_title:Journal of natural medicines
pub_type: 杂志文章
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journal_title:Journal of natural medicines
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journal_title:Journal of natural medicines
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journal_title:Journal of natural medicines
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journal_title:Journal of natural medicines
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doi:10.1007/s11418-015-0956-y
更新日期:2016-07-01 00:00:00
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journal_title:Journal of natural medicines
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journal_title:Journal of natural medicines
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更新日期:2013-07-01 00:00:00
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journal_title:Journal of natural medicines
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pub_type: 杂志文章
doi:10.1007/s11418-010-0464-z
更新日期:2011-01-01 00:00:00
abstract::Evodiae fructus (EF), a fruit of Evodia rutaecarpa Bentham, has long been used as an analgesic drug in traditional Chinese and Japanese medicine. However, the underlying molecular mechanism of its pharmacological action is unclear. Here, using calcium imaging, whole-cell patch-clamp recording, and behavioral analysis,...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-015-0929-1
更新日期:2016-01-01 00:00:00
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journal_title:Journal of natural medicines
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journal_title:Journal of natural medicines
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journal_title:Journal of natural medicines
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journal_title:Journal of natural medicines
pub_type: 杂志文章
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更新日期:2012-04-01 00:00:00
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journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-012-0668-5
更新日期:2013-01-01 00:00:00
abstract::Two new phenolic compounds (1 and 2, named as teasperol and teasperin, respectively) were isolated from fermented tea (Camellia sinensis L.) products, together with known phenolic compounds. Teasperol (1) was isolated from Chinese traditional post-fermented tea leaves (Liu-pao tea) and teasperin (2) was from a Japanes...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-012-0704-5
更新日期:2013-07-01 00:00:00
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journal_title:Journal of natural medicines
pub_type: 杂志文章
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更新日期:2010-07-01 00:00:00
abstract::I investigated the causative agents of licorice-induced pseudoaldosteronism, which is a frequent side effect of Japanese traditional Kampo medicines. Glycyrrhizin (GL), the main ingredient of licorice, is absorbed after being metabolized to glycyrrhetinic acid (GA) by intestinal bacteria, and then metabolized in liver...
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pub_type: 杂志文章,评审
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更新日期:2021-01-22 00:00:00
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journal_title:Journal of natural medicines
pub_type: 杂志文章
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更新日期:2019-01-01 00:00:00
abstract::From the dried rhizomes of Curcuma comosa cultivating in Thailand, 26 known sesquiterpenes were isolated: zederone, zederone epoxide, furanodienone, isofuranodienone, 1(10)Z,4Z-furanodiene-6-one, glechomanolide, dehydrocurdione, neocurdione, curdione, 7 alpha-hydroxyneocurdione, 7 beta-hydroxycurdione, germacrone-1(10...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-008-0282-8
更新日期:2009-01-01 00:00:00
abstract::A new diterpenoid was isolated from the leaves of Clerodendron trichotomumThunb. (Verbenaceae) along with one each of a known diterpenoid, phenylethanoid glycoside, and sterol and two known flavonoids. Their chemical structures were characterized on the basis of spectroscopic data and X-ray analysis. In addition, thei...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-012-0690-7
更新日期:2013-04-01 00:00:00
abstract::Smallanthus sonchifolius (yacon) is a perennial plant mostly cultivated in South America, primarily for use of the tubers as a food crop and the leaves as fodder for livestock. The antibacterial activities of the methanol extract of yacon leaves (S. sonchifolius) and its n-hexane, ethyl acetate, n-butanol and water fr...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-010-0388-7
更新日期:2010-04-01 00:00:00