Abstract：
:Advanced glycation end-products (AGEs) are associated with a non-enzymatic reaction between the amino group of a protein and the carbonyl group of a sugar during hyperglycemia. The precipitation of AGEs in different tissues leads to many complications, such as endothelial dysfunction, cardiovascular complications, atherosclerosis, retinopathy, neuropathy, and Alzheimer's disease. Garcinia mangostana L. (Clusiaceae) (GM) was selected owing to the ability of its polar and non-polar fractions to inhibit AGE formation. For the first time, the bioguided fractionation of its pericarp MeOH extract (GMT) gave rise to two new xanthones, namely, mangostanaxanthones III (1) and IV (3), in addition to six known compounds, β-mangostin (2), garcinone E (4), rubraxanthone (5), α-mangostin (6), garcinone C (7), and 9-hydroxycalabaxanthone (8), from the non-polar faction. Their structures were verified by various spectroscopic methods, including 1D and 2D NMR studies and high-resolution MS data. All of the isolated xanthones significantly inhibited both sugar (ribose) and dicarbonyl compound (methylglyoxal)-induced protein glycation in a dose-dependent manner. This is explained by the ability of the isolated xanthones to inhibit protein oxidation, as indicated by the decreases in dityrosine and N'-formylkynurenine formation.
journal_name
J Nat Medjournal_title
Journal of natural medicinesauthors
Abdallah HM,El-Bassossy HM,Mohamed GA,El-Halawany AM,Alshali KZ,Banjar ZMdoi
10.1007/s11418-016-1051-8subject
Has Abstractpub_date
2017-01-01 00:00:00pages
216-226issue
1eissn
1340-3443issn
1861-0293pii
10.1007/s11418-016-1051-8journal_volume
71pub_type
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journal_title：Journal of natural medicines
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journal_title：Journal of natural medicines
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journal_title：Journal of natural medicines
pub_type： 杂志文章
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更新日期：2017-01-01 00:00:00
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journal_title：Journal of natural medicines
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