Abstract:
:Agarwood oil and spikenard extract were examined for their sedative activity using a spontaneous vapor administration system. It was shown that inhalation of agarwood oil vapor sedated mice. The main volatile constituents of the oil were found to be benzylacetone [agarwood oil from a Hong Kong market (1)], or alpha-gurjunene and (+)-calarene [agarwood oil made in Vietnam (2)]. A hexane extract of spikenard contained a lot of calarene, and its vapor inhalation had a sedative effect on mice. Individual principles benzylacetone, calarene, and alpha-gurjunene were administered to mice, which reproduced the result of the corresponding oil or extract. However, the most effective dose of the compounds was lower than their original content in the oil and extract (benzylacetone 0.1%, calarene 0.17%, alpha-gurjunene 1.5%).
journal_name
J Nat Medjournal_title
Journal of natural medicinesauthors
Takemoto H,Ito M,Shiraki T,Yagura T,Honda Gdoi
10.1007/s11418-007-0177-0subject
Has Abstractpub_date
2008-01-01 00:00:00pages
41-6issue
1eissn
1340-3443issn
1861-0293journal_volume
62pub_type
杂志文章abstract::Nardostachys jatamansi (NJ) has been used in the treatment of inflammatory diseases. However, it is not clear how NJ produces anti-inflammatory effects. In the present study, using an experimental model of lipopolysaccharide (LPS)-induced endotoxin shock, the protective effects and mechanisms of action of NJ were inve...
journal_title:Journal of natural medicines
pub_type: 杂志文章
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更新日期:2011-01-01 00:00:00
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journal_title:Journal of natural medicines
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abstract::Ephedra Herb is a crude drug defined as the terrestrial stem of Ephedra sinica, E. intermedia, or E. equisetina. It is often used to treat headaches, bronchial asthma, nasal inflammation, and the common cold. In this study, we isolated characteristic non-alkaloidal constituents from the extracts and identified them in...
journal_title:Journal of natural medicines
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journal_title:Journal of natural medicines
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doi:10.1007/s11418-008-0308-2
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abstract::Tetrandrine is a cytotoxic compound capable of exerting remarkable antitumor activity against many cancer cells in vitro and in vivo. However, little is known about its effect on human renal cell carcinoma (RCC). In the present study, using RCC 786-O, 769-P and ACHN cell lines as the model system, we demonstrated the ...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-013-0765-0
更新日期:2014-01-01 00:00:00
abstract::Pine needle extract (PE) and fermented pine needle extract (FPE) have been reported to show various biological and pharmacological activities such as antioxidant, anti-inflammatory, anti-bacterial, anti-cholesterol, gastrointestinal motility control, and fibrinolytic effect. The aims of our research were to isolate fi...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-015-0956-y
更新日期:2016-07-01 00:00:00
abstract::The stem of the Akebia plant, "Mokutsu", is a crude diuretic and antiphlogistic drug. Japanese products prepared from wild Akebia plants cover most of the Mokutsu market. Two Akebia plants, Akebia quinata Decaisne (Aq) and A. trifoliata Koidzumi (At) of Lardizabalaceae, are standardized as Mokutsu in Japanese pharmaco...
journal_title:Journal of natural medicines
pub_type: 信件
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更新日期:2009-07-01 00:00:00
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journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-016-0976-2
更新日期:2016-07-01 00:00:00
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journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-012-0646-y
更新日期:2013-01-01 00:00:00
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journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-011-0555-5
更新日期:2012-01-01 00:00:00
abstract::Six cycloartane glycosides, named tareciliosides N-S, and a known iridoid glucoside, ixoroside, were isolated in further extensive studies on the 1-BuOH-soluble fraction of a MeOH extract of the leaves of Tarenna gracilipes. From the EtOAc-soluble fraction, three known triterpenes were isolated. Their toxicities towar...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-012-0707-2
更新日期:2013-07-01 00:00:00
abstract::Seven oleanane-type triterpene saponin bisdesmosides, perennisaponins N-T (1-7), were newly isolated from a methanol extract of daisy, the flowers of Bellis perennis L. (Asteraceae). The structures were determined based on chemical and physicochemical data and confirmed using previously isolated related compounds as r...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-016-0998-9
更新日期:2016-07-01 00:00:00
abstract::Mimosa pudica is used in traditional medicine for treating various disorders such as inflammatory conditions, diarrhoea, insomnia, alopecia, urogenital infections and wounds. The present study investigated the effect of M. pudica extract (MPE) on L-arginine-induced acute necrotising pancreatitis in rats. The ethanolic...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-016-0991-3
更新日期:2016-07-01 00:00:00
abstract::Evodiae fructus (EF), a fruit of Evodia rutaecarpa Bentham, has long been used as an analgesic drug in traditional Chinese and Japanese medicine. However, the underlying molecular mechanism of its pharmacological action is unclear. Here, using calcium imaging, whole-cell patch-clamp recording, and behavioral analysis,...
journal_title:Journal of natural medicines
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journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-011-0609-8
更新日期:2012-07-01 00:00:00
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journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-008-0287-3
更新日期:2009-01-01 00:00:00
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journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-019-01335-2
更新日期:2020-01-01 00:00:00
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journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-012-0654-y
更新日期:2013-01-01 00:00:00
abstract::Eurycomanone, an active constituent isolated from Eurycoma longifolia Jack, was examined for modulatory effects on cytochrome P450 (CYP) isoforms CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2C19, CYP2E1 and CYP3A4 using in vitro assays. The IC50 value was determined to assess the potencies of modulation for each CYP isoform. O...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-013-0794-8
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journal_title:Journal of natural medicines
pub_type: 杂志文章
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更新日期:2018-03-01 00:00:00
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journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-017-1122-5
更新日期:2018-01-01 00:00:00
abstract::Blood-brain barrier (BBB)-permeable components in the methanolic extract of Nelumbo nucifera flowers showed accelerative effects on neurite outgrowth in PC-12 cells. Among the constituents isolated from N. nucifera flowers in our previous study, aporphine-type alkaloids, lirinidine, asimilobine, N-methylasimilobine, a...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-019-01368-7
更新日期:2020-01-01 00:00:00
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journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-018-1225-7
更新日期:2018-09-01 00:00:00
abstract::Antihypertensive treatment is highly important to prevent the progression of chronic kidney disease. Shichimotsukokato (SKT), a traditional Japanese medicine (i.e., Kampo formula), lowered systolic blood pressure (SBP) in experimental animal models of hypertension. However, its mechanism of action has not been fully e...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-015-0945-1
更新日期:2016-04-01 00:00:00
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journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-016-1015-z
更新日期:2016-10-01 00:00:00
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journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-018-1231-9
更新日期:2019-01-01 00:00:00
abstract::The core of solid tumors is characterized by hypoxia and a nutrient-starved microenvironment and has gained much attention as targets of anti-cancer drugs. In the course of search for selective growth inhibitors against the cancer cells adapted to nutrient starvation, epidithiodiketopiperazine DC1149B (1) together wit...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-019-01357-w
更新日期:2020-01-01 00:00:00
abstract::The present study was designed to determine the protective effects of Yucca schidigera (Ys) against oxidative damage induced by acute nitrite intoxication as well as the histopathological evaluation of Ys in rats. The rats were divided into three groups each containing 12 rats: control (C); nitrite intoxication (N); Y...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-009-0338-4
更新日期:2009-07-01 00:00:00
abstract::(E)-methyl-4-hydroxy-3,5-dimethoxycinnamate, (E)-methyl-4-hydroxy-3-methoxycinnamate, (E)-methyl-4-hydroxycinnamate, (Z)-methyl-4-hydroxycinnamate, calycanthine, ursolic acid, 2-hydroxy-3-methylanthraquinone, 4-methoxybenzoic acid, 3,4,5-trimethoxybenzoic acid, methyl 4-hydroxybenzoate and allantoin were isolated from...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-008-0227-2
更新日期:2008-07-01 00:00:00
abstract::Two new xanthones namely cratochinone A (1) and cratochinone B (2), along with 16 known xanthones, were isolated from the roots of Cratoxylum cochinchinense. Their structures were characterized by spectroscopic methods, especially 1D and 2D NMR as well as comparison with those reported in the literature for known xant...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-019-01376-7
更新日期:2020-03-01 00:00:00