Abstract:
:Bioassay-guided chromatographic purification of the antitubercular chloroform extract of Pandanus tectorius Soland. var. laevis leaves afforded a new tirucallane-type triterpene, 24,24-dimethyl-5 beta-tirucall-9(11),25-dien-3-one (1), squalene and a mixture of the phytosterols stigmasterol and beta-sitosterol. Microplate Alamar Blue Assay (MABA) showed that 1 inhibited the growth of Mycobacterium tuberculosis H(37)Rv with a MIC of 64 microg/mL, while squalene and the sterol mixture have MICs of 100 and 128 microg/mL, respectively.
journal_name
J Nat Medjournal_title
Journal of natural medicinesauthors
Tan MA,Takayama H,Aimi N,Kitajima M,Franzblau SG,Nonato MGdoi
10.1007/s11418-007-0218-8subject
Has Abstractpub_date
2008-04-01 00:00:00pages
232-5issue
2eissn
1340-3443issn
1861-0293journal_volume
62pub_type
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