Abstract：
:We investigated the cytotoxicity of six neolignans (1-6), which are similar in structure to furanocyclohexenone with an angular allyl group, in human neuroblastoma cell lines (IMR-32, LA-N-1, NB-39, SK-N-SH) and normal cells [human umbilical vein endothelial cells (HUVEC) and human dermal fibroblasts (HDF)] using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Two neolignans, ferrearin C (1) and 2, showed significant cytotoxicity in neuroblastoma cells. Typical morphologic features of apoptosis were observed for the ferrearin-type neolignans using Hoechst 33342, and apoptotic cytoplasmic membrane inversion was also induced by ferrearin-type neolignans in IMR-32. Furthermore, a Proteome Profiler Array showed that the ferrearin-type neolignans induced the marked expression of heme oxygenase-1 (HO-1). In a western blot analysis, ferrearin C (1) increased the level of Bax and reduced the level of survivin, indicating the activation of the mitochondrial pathway of apoptosis.
journal_name
J Nat Medjournal_title
Journal of natural medicinesauthors
Hayama T,Tabata K,Uchiyama T,Fujimoto Y,Suzuki Tdoi
10.1007/s11418-011-0514-1subject
Has Abstractpub_date
2011-07-01 00:00:00pages
431-9issue
3-4eissn
1340-3443issn
1861-0293journal_volume
65pub_type
杂志文章abstract：:The stem of the Akebia plant, "Mokutsu", is a crude diuretic and antiphlogistic drug. Japanese products prepared from wild Akebia plants cover most of the Mokutsu market. Two Akebia plants, Akebia quinata Decaisne (Aq) and A. trifoliata Koidzumi (At) of Lardizabalaceae, are standardized as Mokutsu in Japanese pharmaco...
journal_title：Journal of natural medicines
pub_type： 信件
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abstract：:Chresta martii (Asteraceae) is a plant found in the Xingó region (semi-arid area) in Northeastearn Brazil, and is recognized by the local population as a traditional herb used to treat gastric diseases. This is the first report of the chemical composition, acute toxicity, and gastroprotective effect in mice of the hyd...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-012-0663-x
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-012-0703-6
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-007-0177-0
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abstract：:Curcuma comosa is widely used as a traditional herbal medicine for gynecological diseases in South East Asia. Previous studies reported that it has phytoestrogenic activity, and several diarylheptanoids were found to be the active constituents. In this study, the pharmacokinetics profile and organ distribution of thre...
journal_title：Journal of natural medicines
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doi：10.1007/s11418-011-0607-x
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-012-0646-y
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-010-0417-6
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-019-01332-5
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journal_title：Journal of natural medicines
pub_type： 杂志文章
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更新日期：2013-07-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-017-1141-2
更新日期：2018-01-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
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journal_title：Journal of natural medicines
pub_type： 杂志文章
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-010-0467-9
更新日期：2011-01-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-017-1081-x
更新日期：2017-07-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-007-0193-0
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journal_title：Journal of natural medicines
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journal_title：Journal of natural medicines
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journal_title：Journal of natural medicines
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journal_title：Journal of natural medicines
pub_type： 杂志文章
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更新日期：2012-04-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
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journal_title：Journal of natural medicines
pub_type： 杂志文章
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更新日期：2012-01-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
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更新日期：2008-07-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
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更新日期：2019-09-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
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更新日期：2014-04-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-011-0574-2
更新日期：2012-04-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-010-0409-6
更新日期：2010-07-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-010-0484-8
更新日期：2011-04-01 00:00:00
