Ferrearin C induces apoptosis via heme oxygenase-1 (HO-1) induction in neuroblastoma.

Abstract:

:We investigated the cytotoxicity of six neolignans (1-6), which are similar in structure to furanocyclohexenone with an angular allyl group, in human neuroblastoma cell lines (IMR-32, LA-N-1, NB-39, SK-N-SH) and normal cells [human umbilical vein endothelial cells (HUVEC) and human dermal fibroblasts (HDF)] using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Two neolignans, ferrearin C (1) and 2, showed significant cytotoxicity in neuroblastoma cells. Typical morphologic features of apoptosis were observed for the ferrearin-type neolignans using Hoechst 33342, and apoptotic cytoplasmic membrane inversion was also induced by ferrearin-type neolignans in IMR-32. Furthermore, a Proteome Profiler Array showed that the ferrearin-type neolignans induced the marked expression of heme oxygenase-1 (HO-1). In a western blot analysis, ferrearin C (1) increased the level of Bax and reduced the level of survivin, indicating the activation of the mitochondrial pathway of apoptosis.

journal_name

J Nat Med

authors

Hayama T,Tabata K,Uchiyama T,Fujimoto Y,Suzuki T

doi

10.1007/s11418-011-0514-1

subject

Has Abstract

pub_date

2011-07-01 00:00:00

pages

431-9

issue

3-4

eissn

1340-3443

issn

1861-0293

journal_volume

65

pub_type

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