Abstract:
:Blood-brain barrier (BBB)-permeable components in the methanolic extract of Nelumbo nucifera flowers showed accelerative effects on neurite outgrowth in PC-12 cells. Among the constituents isolated from N. nucifera flowers in our previous study, aporphine-type alkaloids, lirinidine, asimilobine, N-methylasimilobine, and pronuciferine, showed accelerative effects. Lirinidine, N-methylasimilobine, and an alkaloid-rich diethyl ether fraction at low concentrations increased the expression of mRNAs coding for TrkA, Vav3, and Rac1. In addition, good permeability of asimilobine and N-methylasimilobine was confirmed using an in vitro BBB model. Asimilobine and N-methylasimilobine are considered to be suitable as seed compounds of drugs for Alzheimer's disease, because of their activity and BBB permeability.
journal_name
J Nat Medjournal_title
Journal of natural medicinesauthors
Yano M,Nakashima S,Oda Y,Nakamura S,Matsuda Hdoi
10.1007/s11418-019-01368-7subject
Has Abstractpub_date
2020-01-01 00:00:00pages
212-218issue
1eissn
1340-3443issn
1861-0293pii
10.1007/s11418-019-01368-7journal_volume
74pub_type
杂志文章abstract::The root of Angelica acutiloba Kitagawa is an important crude drug in Kampo medicines (traditional Japanese medicine). Chemical evaluation of crude drugs is crucial to ensuring the safety and efficacy of herbal medicine; however, there is currently no chemical standard for the A. acutiloba crude drug in Japanese pharm...
journal_title:Journal of natural medicines
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doi:10.1007/s11418-018-1190-1
更新日期:2018-06-01 00:00:00
abstract::This experiment's with aim was to study the pharmacokinetics of asperosaponin VI and its three metabolites (cauloside A, HN saponin F and hederagenin) via a sensitive high performance liquid chromatography connected with electrospray ionization triple quadrupole mass spectrum (HPLC-ESI-MS/MS). Chromatographic separati...
journal_title:Journal of natural medicines
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doi:10.1007/s11418-014-0821-4
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abstract::Ancient Chinese medicine treatises on Atractylodis Macrocephalae Rhizoma (AMR), the rhizome of Atractylodes macrocephala Koidz, indicated that it possessed an expectorant effect. However, in modern times, it is commonly used as a tocolytic agent. In this study, the components of AMR that are responsible for its expect...
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pub_type: 杂志文章
doi:10.1007/s11418-015-0934-4
更新日期:2016-01-01 00:00:00
abstract::Near-infrared (NIR) spectroscopy combined with chemometrics has been utilized in predictions of natural medicine content without destroying samples. Suppositories (oren powdered extract content 0, 0.5, 1.0, 2.5, 10, 12.5, and 15%) were produced by mixing oren powdered extract with macrogol mixture consisting of 1 part...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-011-0596-9
更新日期:2012-04-01 00:00:00
abstract::Liver fibrosis is considered to be a result of chronic liver pathological changes, and hepatic stellate cells (HSCs) play an important role during this process. Evodiamine, an indole alkaloid derived from Evodia rutaecarpa, exhibits pharmacological activities. This study focused on the effects of evodiamine on carbon ...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-017-1122-5
更新日期:2018-01-01 00:00:00
abstract::Although Radix Angelicae dahuricae (Angelica) has been traditionally used in patients with rheumatism arthralgia, its bioactive ingredients remain to be determined. In this study, the essential oil extract of Radix Angelicae dahuricae (EOAD) was assessed for its anti-inflammatory activities against xylene-induced acut...
journal_title:Journal of natural medicines
pub_type: 杂志文章
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abstract::Antihypertensive treatment is highly important to prevent the progression of chronic kidney disease. Shichimotsukokato (SKT), a traditional Japanese medicine (i.e., Kampo formula), lowered systolic blood pressure (SBP) in experimental animal models of hypertension. However, its mechanism of action has not been fully e...
journal_title:Journal of natural medicines
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更新日期:2016-04-01 00:00:00
abstract::Cancer cachexia is a complex and multifactorial syndrome that influences about 50-80% of cancer patients and may lead to 20% of cancer deaths and muscle atrophy is the key characteristic of the syndrome. Recent researches have shown that myostatin is a negative regulator in the growth and differentiation of skeletal m...
journal_title:Journal of natural medicines
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journal_title:Journal of natural medicines
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更新日期:2014-07-01 00:00:00
abstract::Visceral obesity induces insulin resistance and is recognized as an important risk factor for metabolic syndrome (MS). Therefore, inhibition of lipid absorption from the intestine is regarded as an effective way of preventing MS. Terminalia bellirica is extensively used in Ayurvedic medicine in India and neighboring c...
journal_title:Journal of natural medicines
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更新日期:2012-07-01 00:00:00
abstract::An immunoassay system was established for the estimation of the quantity of an antitumor cyclic hexapeptide RA-VII (1) from Rubia cordifolia L. and R. akane Nakai (Rubiaceae). First, 1 was converted into its hapten, which was then conjugated with a carrier protein to be used as an effective antigen to obtain its monoc...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-011-0508-z
更新日期:2011-07-01 00:00:00
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journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-009-0346-4
更新日期:2009-10-01 00:00:00
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journal_title:Journal of natural medicines
pub_type: 临床试验,杂志文章
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更新日期:2009-04-01 00:00:00
abstract::A new β-carboline alkaloid (1) and two new matrine-type alkaloids (2 and 3), together with two known alkaloids (4 and 5), were isolated from the roots of Sophora tonkinensis. The new structures were elucidated via extensive analyses of the spectroscopic data (IR, UV, HRESIMS, NMR) and X-ray crystallography. The absolu...
journal_title:Journal of natural medicines
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journal_title:Journal of natural medicines
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doi:10.1007/s11418-007-0218-8
更新日期:2008-04-01 00:00:00
abstract::Rhamnan sulfate (RS) is a polysaccharide with a rhamnose backbone isolated from Monostroma nitidum. Like heparin, it exerts anticoagulant activity in the presence of antithrombin. Endothelial cells facilitate the crosstalk between blood coagulation and vascular inflammation. In this study, we compared the effect of RS...
journal_title:Journal of natural medicines
pub_type: 杂志文章
doi:10.1007/s11418-019-01289-5
更新日期:2019-06-01 00:00:00
abstract::Species of genus Ocimum (Lamiaceae) are economically important due to their essential oils and utilization as medicine for many disorders, including the central nervous system. A previous study showed seasonal variations in chemical profile and in central nervous system activities of essential oil from Ocimum gratissi...
journal_title:Journal of natural medicines
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doi:10.1007/s11418-010-0429-2
更新日期:2010-10-01 00:00:00
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journal_title:Journal of natural medicines
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更新日期:2017-01-01 00:00:00
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更新日期:2020-01-01 00:00:00
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journal_title:Journal of natural medicines
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更新日期:2011-07-01 00:00:00
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journal_title:Journal of natural medicines
pub_type: 杂志文章
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更新日期:2018-06-01 00:00:00
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journal_title:Journal of natural medicines
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journal_title:Journal of natural medicines
pub_type: 杂志文章
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更新日期:2009-04-01 00:00:00
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journal_title:Journal of natural medicines
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journal_title:Journal of natural medicines
pub_type: 杂志文章
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更新日期:2018-01-01 00:00:00
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journal_title:Journal of natural medicines
pub_type: 杂志文章
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