当前位置： SCI文献检索 > Journal of Natural Medicines期刊下所有文献 > Effect of phenylalanine on Taxol production and antioxidant activity of extracts of suspension-cultured hazel (Corylus avellana L.) cells.

Effect of phenylalanine on Taxol production and antioxidant activity of extracts of suspension-cultured hazel (Corylus avellana L.) cells.

Abstract：

:Taxol is produced by a few microorganisms and plants such as yew (Taxus sp.). Recent researches have shown that hazel (Corylus avellana L.) is also able to produce Taxol. In the present study, effects of different concentrations of phenylalanine (Phe) on the production of Taxol, antioxidant activity, and cytotoxic effects of extracts of suspension-cultured hazel cells were investigated. The cells were treated with different concentrations of Phe on day 7 of subculture and were harvested on day 14. The results showed that the amounts of Taxol and antioxidant activity were increased by increasing the phenylalanine supply. Interestingly, the cytotoxic effects of hazel cell extract were even stronger than that of pure Taxol (standard), suggesting hazel cell extract as a novel and suitable probe for treating human cancer. Application of phenylalanine to hazel cells exaggerates their effects.

journal_name

J Nat Med

journal_title

Journal of natural medicines

authors

Bemani E,Ghanati F,Rezaei A,Jamshidi M

doi

10.1007/s11418-012-0696-1

subject

Has Abstract

pub_date

2013-07-01 00:00:00

pages

446-51

issue

3

eissn

1340-3443

issn

1861-0293

journal_volume

67

pub_type

杂志文章

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