Three new alkaloids from the roots of Sophora tonkinensis.

abstract：:Eight new furostanol glycosides (1-8), together with two known ones (9 and 10), have been isolated from a glycoside-enriched fraction prepared from the rhizomes of Helleborus orientalis (Ranunculaceae). The structures of 1-8 were determined on the basis of extensive spectroscopic analysis, including 2D NMR, and the re...

journal_title：Journal of natural medicines

authors： Mimaki Y,Matsuo Y,Watanabe K,Sakagami H

更新日期：2010-10-01 00:00:00

abstract：:A new phenylethanoid, 1-O-β-D-(4-hydroxyphenyl)-ethyl-6-O-vanilloyl-glucopyranoside (1), and a new furofuran lignan, (7R,7'R,7''S,8S,8'S,8''R)-4', 4''-dihydroxy-3,3',3'',5-tetramethoxy-7,9':7'9-diepoxy-4,8''-oxy-8,8'-sesquineolignan-7'',9''-diol (2), along with five known compounds (3-7) were isolated from the roots o...

journal_title：Journal of natural medicines

authors： Xiong H,Zhao F,Bi J,Zhang Y,Zhao G,Chen X,Li Y,Yan R,Zhao Q,Qiao H,Zhang G

更新日期：2016-07-01 00:00:00

abstract：:Alkaline hydrolysis of the ether-insoluble resin glycoside (convolvulin) fraction of the seeds of Quamoclit × multifida (syn. Q. sloteri House, Convolvulaceae), a hybrid between Q. pennat and Q. coccinea, gave three new glycosidic acids (maltifidinic acids C, D, and E) along with three known glycosidic acids (quamocli...

journal_title：Journal of natural medicines

authors： Ono M,Kishida M,Ikegami Y,Takaki Y,Okawa M,Kinjo J,Yoshimitsu H,Nohara T,Miyahara K

更新日期：2011-01-01 00:00:00

abstract：:The core of solid tumors is characterized by hypoxia and a nutrient-starved microenvironment and has gained much attention as targets of anti-cancer drugs. In the course of search for selective growth inhibitors against the cancer cells adapted to nutrient starvation, epidithiodiketopiperazine DC1149B (1) together wit...

journal_title：Journal of natural medicines

authors： Tang R,Kimishima A,Ishida R,Setiawan A,Arai M

更新日期：2020-01-01 00:00:00

abstract：:Successive oral administration (50 mg/kg) of a 50% ethanolic extract (HP-ext) of devil's claw, the secondary root of Harpagophytum procumbens, showed a significant anti-inflammatory effect in the rat adjuvant-induced chronic arthritis model. HP-ext dose-dependently suppressed the lipopolysaccharide (LPS)-induced produ...

journal_title：Journal of natural medicines

authors： Inaba K,Murata K,Naruto S,Matsuda H

更新日期：2010-04-01 00:00:00

abstract：:Advanced glycation end-products (AGEs) are associated with a non-enzymatic reaction between the amino group of a protein and the carbonyl group of a sugar during hyperglycemia. The precipitation of AGEs in different tissues leads to many complications, such as endothelial dysfunction, cardiovascular complications, ath...

journal_title：Journal of natural medicines

authors： Abdallah HM,El-Bassossy HM,Mohamed GA,El-Halawany AM,Alshali KZ,Banjar ZM

更新日期：2017-01-01 00:00:00

abstract：:Ephedra Herb is a crude drug defined as the terrestrial stem of Ephedra sinica, E. intermedia, or E. equisetina. It is often used to treat headaches, bronchial asthma, nasal inflammation, and the common cold. In this study, we isolated characteristic non-alkaloidal constituents from the extracts and identified them in...

journal_title：Journal of natural medicines

authors： Oshima N,Yamashita T,Uchiyama N,Hyuga S,Hyuga M,Yang J,Hakamatsuka T,Hanawa T,Goda Y

更新日期：2019-01-01 00:00:00

abstract：:Atherosclerosis is a major cause of coronary heart disease. As a result of the development of atherosclerotic lesions, the walls of blood vessels become thicker and inhibit blood circulation. Atherosclerosis is caused by a high-fat diet and vascular injury. Chronic arterial inflammation plays an important role in the ...

journal_title：Journal of natural medicines

authors： Ham YM,Song HS,Kwon JE,Jeon H,Baek HJ,Kim CW,Yoon WJ,Choung ES,Kang SC

更新日期：2019-01-01 00:00:00

abstract：:The effects on guinea-pig heart muscle of extracts of Apocynum venetum L. leaf, root, stem, old stem and Venetron--a polyphenol-rich extract of leaves--were studied by recording the mechanical activity and heart rate of isolated right atria. Cymarin--a cardiac glycoside--was also determined in A. venetum extracts by L...

journal_title：Journal of natural medicines

authors： Irie K,Sato T,Tanaka I,Nakajima J,Kawaguchi M,Himi T

更新日期：2009-04-01 00:00:00

abstract：:Pine needle extract (PE) and fermented pine needle extract (FPE) have been reported to show various biological and pharmacological activities such as antioxidant, anti-inflammatory, anti-bacterial, anti-cholesterol, gastrointestinal motility control, and fibrinolytic effect. The aims of our research were to isolate fi...

journal_title：Journal of natural medicines

authors： Park J,Lee B,Choi H,Kim W,Kim HJ,Cheong H

更新日期：2016-07-01 00:00:00

abstract：:From the 1-BuOH-soluble fraction of a MeOH extract of Euphorbia hirta, collected in the Okinawa islands, three new megastigmane glucoside gallates, named hirtionosides A-C, 3-hydroxyoctanoic acid glucosides and a phenylpropanoid glucoside were isolated along with 15 known compounds. The structures of the new compounds...

journal_title：Journal of natural medicines

authors： Nomoto Y,Sugimoto S,Matsunami K,Otsuka H

更新日期：2013-04-01 00:00:00

abstract：:Two new xanthones namely cratochinone A (1) and cratochinone B (2), along with 16 known xanthones, were isolated from the roots of Cratoxylum cochinchinense. Their structures were characterized by spectroscopic methods, especially 1D and 2D NMR as well as comparison with those reported in the literature for known xant...

journal_title：Journal of natural medicines

authors： Natrsanga P,Jongaramruong J,Rassamee K,Siripong P,Tip-Pyang S

更新日期：2020-03-01 00:00:00

abstract：:Twenty-three new C21 steroidal glycosides, marstenacissides C1-C10 (1-10), D1-D7 (11-17) and E1-E6 (18-23), and four new C21 steroids, 11α,12β-O-ditigloyl-tenacigenin C (24), 11α-O-benzoyl-12β-O-tigloyl-tenacigenin C (25), 11α-O-tigloyl-12β-O-benzoyl-tenacigenin C (26) and 11α-O-tigloyl-12β-O-benzoyl-marsdenin (27), w...

journal_title：Journal of natural medicines

authors： Pang X,Kang LP,Fang XM,Yu HS,Han LF,Zhao Y,Zhang LX,Yu LY,Ma BP

更新日期：2018-01-01 00:00:00

abstract：:A new pyrrolidine derivative, (5S)-hydroxyethyl 2-oxopyrrolidine-5-carboxylate (1), a new flavonol glycoside, tamaraxetin 3,7-di-O-α-L-rhamnopyranoside (2), and a new triterpene saponin, polyscioside A methyl ester (3), along with six known compounds (4-9) were isolated from the leaves of Polyscias balfouriana. Their ...

journal_title：Journal of natural medicines

authors： Sugimoto S,Yamano Y,Khalil HE,Otsuka H,Kamel MS,Matsunami K

更新日期：2017-07-01 00:00:00

abstract：:A novel C20 natural product, acacienone (1), was isolated from the leaves of Acacia mangium collected in Bangladesh. The structure of compound 1 was elucidated by spectral studies and X-ray crystallographic analysis. Acacienone (1) possesses a terpenoid-related tetracyclic framework containing 20 carbons with biogenet...

journal_title：Journal of natural medicines

authors： Hara Y,Totsugi Y,Ichikawa H,Harada S,Fujii K,Ahmed F,Sadhu SK,Arai MA,Ishibashi M

更新日期：2021-01-01 00:00:00

abstract：:Two new diterpenoids, 14α-hydroxy-9α,13α-epoxylabd-5(6)-en-7-on-16,15-olide (1) and 13ξ-hydroxylabd-5(6),8(9)-dien-7-on-16,15-olide (2) along with six known diterpenoids were isolated from the aerial parts of Leonotis leonurus R. Br. These structures were determined on the basis of spectroscopic analyses. Some of the ...

journal_title：Journal of natural medicines

authors： Narukawa Y,Komori M,Niimura A,Noguchi H,Kiuchi F

更新日期：2015-01-01 00:00:00

abstract：:We investigated the cytotoxicity of six neolignans (1-6), which are similar in structure to furanocyclohexenone with an angular allyl group, in human neuroblastoma cell lines (IMR-32, LA-N-1, NB-39, SK-N-SH) and normal cells [human umbilical vein endothelial cells (HUVEC) and human dermal fibroblasts (HDF)] using a 3-...

journal_title：Journal of natural medicines

authors： Hayama T,Tabata K,Uchiyama T,Fujimoto Y,Suzuki T

更新日期：2011-07-01 00:00:00

abstract：:The purpose of the present study was to investigate the protective effects of combined therapy of garlic homogenate and hydrochlorothiazide (HCTZ) in animals with hypertension and myocardial damage. Three weeks of high fructose (10% w/v) in fluid to albino rats resulted in hypertension. They were subsequently administ...

journal_title：Journal of natural medicines

authors： Asdaq SM,Inamdar MN

更新日期：2011-01-01 00:00:00

abstract：:Eight bastadins, tetramers of brominated-tyrosine derivatives, were isolated from the marine sponge Ianthella basta, and their anti-proliferative activities against endothelial cells were examined. A structure-activity relationship study of these compounds revealed that a macrocyclic structure was crucial, and a basta...

journal_title：Journal of natural medicines

authors： Aoki S,Cho SH,Hiramatsu A,Kotoku N,Kobayashi M

更新日期：2006-07-01 00:00:00

abstract：:We have previously shown that the two sesquiterpene lactones, salograviolide A (Sal A) and iso-seco-tanapartholide (TNP), isolated from the Middle Eastern indigenous plants Centaurea ainetensis and Achillea falcata, respectively, possess selective antitumor properties. Here, we aimed to assess the anticancer effects o...

journal_title：Journal of natural medicines

authors： Salla M,Fakhoury I,Saliba N,Darwiche N,Gali-Muhtasib H

更新日期：2013-07-01 00:00:00

abstract：:Liver fibrosis is considered to be a result of chronic liver pathological changes, and hepatic stellate cells (HSCs) play an important role during this process. Evodiamine, an indole alkaloid derived from Evodia rutaecarpa, exhibits pharmacological activities. This study focused on the effects of evodiamine on carbon ...

journal_title：Journal of natural medicines

authors： Yang D,Li L,Qian S,Liu L

更新日期：2018-01-01 00:00:00

abstract：:In a previous study, we found that both synthetic 3-O-methylquercetin (3MQ) and 3,4',7-O-trimethylquercetin (34'7TMQ) increased extracellular melanin content. 34'7TMQ increased the activity of melanogenic enzymes by stimulating the p38 pathway and the expression of microphthalmia-associated transcription factor (MITF)...

journal_title：Journal of natural medicines

authors： Yamauchi K,Mitsunaga T

更新日期：2018-03-01 00:00:00

abstract：:A new oxygenated lanostane-type triterpene, named lucidumol C, together with six known compounds, was isolated from the chloroform extract of the fruiting bodies of Ganoderma lingzhi. Structures were established based on extensive spectroscopic and chemical studies. Potential cytotoxic activities of the isolated compo...

journal_title：Journal of natural medicines

authors： Amen YM,Zhu Q,Tran HB,Afifi MS,Halim AF,Ashour A,Mira A,Shimizu K

更新日期：2016-07-01 00:00:00

abstract：:Five polyphenolic compounds were identified from the diethyl ether and ethyl acetate extracts of the herb of ragged robin, Lychnis flos-cuculi L. (Caryophyllaceae). The identified and isolated compounds were established as a caffeic acid, luteolin, apigenin, apigenin 8-C-beta-D-glucopyranoside (vitexin) and luteolin 8...

journal_title：Journal of natural medicines

authors： Tomczyk M

更新日期：2008-10-01 00:00:00

abstract：:The predominant feature of type 2 diabetes is insulin resistance. Identifying a drug able to reduce insulin resistance is an urgent requirement. ent-3α-Formylabieta-8(14),13(15)-dien-16,12β-olide had been identified as a new diterpene derivative which showed anticancer activity. This study explores the hypoglycemic ef...

journal_title：Journal of natural medicines

authors： Hou P,Qu Y,Liao Z,Zhao S,Feng Y,Zhang J

更新日期：2020-03-01 00:00:00

abstract：:From the dried rhizomes of Curcuma comosa cultivating in Thailand, 26 known sesquiterpenes were isolated: zederone, zederone epoxide, furanodienone, isofuranodienone, 1(10)Z,4Z-furanodiene-6-one, glechomanolide, dehydrocurdione, neocurdione, curdione, 7 alpha-hydroxyneocurdione, 7 beta-hydroxycurdione, germacrone-1(10...

journal_title：Journal of natural medicines

authors： Qu Y,Xu F,Nakamura S,Matsuda H,Pongpiriyadacha Y,Wu L,Yoshikawa M

更新日期：2009-01-01 00:00:00

abstract：:Fufang Xueshuantong Capsule (FXST) can reduce urinary albumin and whole blood viscosity in early diabetic nephropathy (DN) patients. This research aimed to investigate the effect of FXST on kidney function in DN rats and to identify the underlying molecular mechanisms. We performed Illumina RatRef-12 Expression BeadCh...

journal_title：Journal of natural medicines

authors： Zhang Q,Xiao X,Li M,Li W,Yu M,Zhang H,Sun X,Mao L,Xiang H

更新日期：2013-01-01 00:00:00

abstract：:Two novel monoterpenes, sibiscolacton (1) and sibiraic acid (2), were isolated from the aerial part of Sibiraea angustata RCHD: . along with seven known compounds, namely three phenylpropanoids (3-5), two flavonoids (6,7), one glucityl ferulate (8, sibirate), and a monoterpene glucoside (9, sibiskoside). The structure...

journal_title：Journal of natural medicines

authors： Li B,Lee JB,Hayashi K,Ito Y,Sun WJ,Wang X,Kano Y,Hayashi T

更新日期：2010-01-01 00:00:00

abstract：:Two new phenanthrene and 9, 10-dihydrophenanthrene derivatives (1-2) with six known congeners (3-8) were isolated from the extraction of stems of Dendrobium officinale. Compounds 1 and 2 were based on carbon skeleton in which phenanthrene and 9, 10-dihydrophenanthrene moiety were linked with a phenylpropane unit throu...

journal_title：Journal of natural medicines

authors： Zhao GY,Deng BW,Zhang CY,Cui YD,Bi JY,Zhang GG

更新日期：2018-01-01 00:00:00

abstract：:Evodiae fructus (EF), a fruit of Evodia rutaecarpa Bentham, has long been used as an analgesic drug in traditional Chinese and Japanese medicine. However, the underlying molecular mechanism of its pharmacological action is unclear. Here, using calcium imaging, whole-cell patch-clamp recording, and behavioral analysis,...

journal_title：Journal of natural medicines

authors： Iwaoka E,Wang S,Matsuyoshi N,Kogure Y,Aoki S,Yamamoto S,Noguchi K,Dai Y

更新日期：2016-01-01 00:00:00