Two new compounds from the roots of Ilex pubescens and their cytotoxic activity.

abstract：:Taxol is produced by a few microorganisms and plants such as yew (Taxus sp.). Recent researches have shown that hazel (Corylus avellana L.) is also able to produce Taxol. In the present study, effects of different concentrations of phenylalanine (Phe) on the production of Taxol, antioxidant activity, and cytotoxic eff...

journal_title：Journal of natural medicines

authors： Bemani E,Ghanati F,Rezaei A,Jamshidi M

更新日期：2013-07-01 00:00:00

abstract：:Visceral obesity induces insulin resistance and is recognized as an important risk factor for metabolic syndrome (MS). Therefore, inhibition of lipid absorption from the intestine is regarded as an effective way of preventing MS. Terminalia bellirica is extensively used in Ayurvedic medicine in India and neighboring c...

journal_title：Journal of natural medicines

authors： Makihara H,Shimada T,Machida E,Oota M,Nagamine R,Tsubata M,Kinoshita K,Takahashi K,Aburada M

更新日期：2012-07-01 00:00:00

abstract：:The article Comparison of glycyrrhizin content in 25 major kinds of Kampo extracts containing Glycyrrhizae Radix used clinically in Japan, written by Mitsuhiko Nose, Momoka Tada, Rika Kojima, Kumiko Nagata, Shinsuke Hisaka, Sayaka Masada, Masato Homma and Takashi Hakamatsuka, was originally published Online First with...

journal_title：Journal of natural medicines

authors： Nose M,Tada M,Kojima R,Nagata K,Hisaka S,Masada S,Homma M,Hakamatsuka T

更新日期：2018-03-01 00:00:00

abstract：:The predominant feature of type 2 diabetes is insulin resistance. Identifying a drug able to reduce insulin resistance is an urgent requirement. ent-3α-Formylabieta-8(14),13(15)-dien-16,12β-olide had been identified as a new diterpene derivative which showed anticancer activity. This study explores the hypoglycemic ef...

journal_title：Journal of natural medicines

authors： Hou P,Qu Y,Liao Z,Zhao S,Feng Y,Zhang J

更新日期：2020-03-01 00:00:00

abstract：:Mimosa pudica is used in traditional medicine for treating various disorders such as inflammatory conditions, diarrhoea, insomnia, alopecia, urogenital infections and wounds. The present study investigated the effect of M. pudica extract (MPE) on L-arginine-induced acute necrotising pancreatitis in rats. The ethanolic...

journal_title：Journal of natural medicines

authors： Kaur J,Sidhu S,Chopra K,Khan MU

更新日期：2016-07-01 00:00:00

abstract：:Three new compounds, (3S)-dihydrobonducellin 8-O-β-D-glucopyranoside (1), 3',5'-dimethoxy-jezonolid (2), and latisilinoid (3), along with 16 known compounds, were isolated from the twigs of Caesalpinia latisiliqua (Leguminosae). The known compounds were identified as flavonoids, stilbenes, and phenolics as determined ...

journal_title：Journal of natural medicines

authors： Oh M,Park S,Song JH,Ko HJ,Kim SH

更新日期：2020-01-01 00:00:00

abstract：:Near-infrared (NIR) spectroscopy combined with chemometrics has been utilized in predictions of natural medicine content without destroying samples. Suppositories (oren powdered extract content 0, 0.5, 1.0, 2.5, 10, 12.5, and 15%) were produced by mixing oren powdered extract with macrogol mixture consisting of 1 part...

journal_title：Journal of natural medicines

authors： Teraoka R,Abe H,Sugama T,Ito K,Aburada M,Otsuka M

更新日期：2012-04-01 00:00:00

abstract：:Two new phenolic compounds (1 and 2, named as teasperol and teasperin, respectively) were isolated from fermented tea (Camellia sinensis L.) products, together with known phenolic compounds. Teasperol (1) was isolated from Chinese traditional post-fermented tea leaves (Liu-pao tea) and teasperin (2) was from a Japanes...

journal_title：Journal of natural medicines

authors： Kanegae A,Sakamoto A,Nakayama H,Nakazono Y,Yakashiro I,Matsuo Y,Tanaka T,Ishimaru K

更新日期：2013-07-01 00:00:00

abstract：:Since prostate growth is governed by the androgen signaling pathway, blockade of the pathway is regarded as an appropriate strategy for the treatment of benign prostatic hyperplasia (BPH). Panax ginseng is known to have various pharmacological activities. Of several products of its root, red ginseng, having many bioac...

journal_title：Journal of natural medicines

authors： Bae JS,Park HS,Park JW,Li SH,Chun YS

更新日期：2012-07-01 00:00:00

abstract：:Euphorbia hirta L. has been widely used in India and Chinese society. The molecular pharmacology basis of its anti-inflammatory effect is revealed in this work. The ethanol extract of Euphorbia hirta L. (Eh) and its active component were studied in lipopolysaccharide (LPS)-activated macrophage cells (RAW 264.7) as an ...

journal_title：Journal of natural medicines

authors： Shih MF,Cheng YD,Shen CR,Cherng JY

更新日期：2010-07-01 00:00:00

abstract：:From the 1-BuOH-soluble fraction of a MeOH extract of the leaves of Guettarda speciosa L., two new compounds (1, 2) were isolated together with six known compounds. Spectroscopic analysis of 1 and 2 established their structures to be derivatives of a glycerol α-glucuronide and a megastigmane glycoside, respectively. H...

journal_title：Journal of natural medicines

authors： Cai WH,Matsunami K,Otsuka H,Shinzato T,Takeda Y

更新日期：2011-04-01 00:00:00

abstract：:Fufang Xueshuantong Capsule (FXST) can reduce urinary albumin and whole blood viscosity in early diabetic nephropathy (DN) patients. This research aimed to investigate the effect of FXST on kidney function in DN rats and to identify the underlying molecular mechanisms. We performed Illumina RatRef-12 Expression BeadCh...

journal_title：Journal of natural medicines

authors： Zhang Q,Xiao X,Li M,Li W,Yu M,Zhang H,Sun X,Mao L,Xiang H

更新日期：2013-01-01 00:00:00

abstract：:An immunoassay system was established for the estimation of the quantity of an antitumor cyclic hexapeptide RA-VII (1) from Rubia cordifolia L. and R. akane Nakai (Rubiaceae). First, 1 was converted into its hapten, which was then conjugated with a carrier protein to be used as an effective antigen to obtain its monoc...

journal_title：Journal of natural medicines

authors： Hasuda T,Hitotsuyanagi Y,Takeya K

更新日期：2011-07-01 00:00:00

abstract：:In recent years, Spirulina has gained more and more attention from medical scientists as a nutraceutical and a source of potential pharmaceuticals. The present study was conducted to elucidate the immunomodulatory effect of Spirulina fusiformis (a cyanobacterium of the family Oscillatoriaceae) in vivo and in vitro. Th...

journal_title：Journal of natural medicines

authors： Rasool M,Sabina EP

更新日期：2009-04-01 00:00:00

abstract：:Alkaline hydrolysis of the ether-insoluble resin glycoside (convolvulin) fraction of the seeds of Quamoclit × multifida (syn. Q. sloteri House, Convolvulaceae), a hybrid between Q. pennat and Q. coccinea, gave three new glycosidic acids (maltifidinic acids C, D, and E) along with three known glycosidic acids (quamocli...

journal_title：Journal of natural medicines

authors： Ono M,Kishida M,Ikegami Y,Takaki Y,Okawa M,Kinjo J,Yoshimitsu H,Nohara T,Miyahara K

更新日期：2011-01-01 00:00:00

abstract：:To date, there are very few effective drugs for liver fibrosis treatment; therefore, it is urgent to develop novel therapeutic targets and approaches. In the present research, we sought to study the protective effect of sweroside contained in Lonicera japonica or blue honeysuckle berries in a mouse model of liver fibr...

journal_title：Journal of natural medicines

authors： Gong J,Yang F,Yang Q,Tang X,Shu F,Xu L,Wang Z,Yang L

更新日期：2020-01-01 00:00:00

abstract：:A new depsidone, paucinervin Q (1), a new dichromone, paucinervin R (2), and a known compound, paucinervin B (3), were isolated from the stems of Garcinia paucinervis by various chromatographic methods. Their structures were determined by analysis of spectroscopic data. The isolates were evaluated for their antiprolif...

journal_title：Journal of natural medicines

authors： Jia C,Xue J,Li X,Li D,Li Z,Hua H

更新日期：2019-01-01 00:00:00

abstract：:Eight new furostanol glycosides (1-8), together with two known ones (9 and 10), have been isolated from a glycoside-enriched fraction prepared from the rhizomes of Helleborus orientalis (Ranunculaceae). The structures of 1-8 were determined on the basis of extensive spectroscopic analysis, including 2D NMR, and the re...

journal_title：Journal of natural medicines

authors： Mimaki Y,Matsuo Y,Watanabe K,Sakagami H

更新日期：2010-10-01 00:00:00

abstract：:The hypolipidemic activity of Symplocos cochinchinensis S. Moore leaves was studied in Triton WR-1339- and high fat diet-induced hyperlipidemic rats. In Triton WR-1339-induced hyperlipidemic rats, the hexane extract (250 and 500 mg/kg) exerted a significant (P < 0.01) lipid-lowering effect compared to ethyl acetate an...

journal_title：Journal of natural medicines

authors： Sunil C,Ignacimuthu S,Kumarappan C

更新日期：2012-01-01 00:00:00

abstract：:Eurycomanone, an active constituent isolated from Eurycoma longifolia Jack, was examined for modulatory effects on cytochrome P450 (CYP) isoforms CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2C19, CYP2E1 and CYP3A4 using in vitro assays. The IC50 value was determined to assess the potencies of modulation for each CYP isoform. O...

journal_title：Journal of natural medicines

authors： Pan Y,Tiong KH,Abd-Rashid BA,Ismail Z,Ismail R,Mak JW,Ong CE

更新日期：2014-04-01 00:00:00

abstract：:Aloperine (ALO), one of the alkaloids isolated from Sophora alopecuroides L., is traditionally used for various diseases including neuronal disorders. This study investigated the protective effects of ALO on neonatal rat primary-cultured hippocampal neurons injured by oxygen-glucose deprivation and reperfusion (OGD/RP...

journal_title：Journal of natural medicines

authors： Ma NT,Zhou R,Chang RY,Hao YJ,Ma L,Jin SJ,Du J,Zheng J,Zhao CJ,Niu Y,Sun T,Li W,Koike K,Yu JQ,Li YX

更新日期：2015-10-01 00:00:00

abstract：:Crude extract of Juniperus excelsa (JeExt), which tested positive for the presence of anthraquinone, flavonoids, saponins, sterols, terpenes and tannin, exhibited a protective effect against castor oil-induced diarrhoea in mice at 100-1000 mg/kg. In rabbit jejunum preparations, JeExt (0.01-1.0 mg/mL) caused relaxation...

journal_title：Journal of natural medicines

authors： Khan M,Khan AU,Najeeb-ur-Rehman,Gilani AH

更新日期：2012-04-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) possesses two distinct enzymatic activities: those of RNA- and DNA-dependent DNA polymerases and RNase H. In the current HIV-1 therapy, all HIV-1 RT inhibitors inhibit the activity of DNA polymerase, but not that of RNase H. We previously reported ...

journal_title：Journal of natural medicines

authors： Hisayoshi T,Shinomura M,Yokokawa K,Kuze I,Konishi A,Kawaji K,Kodama EN,Hata K,Takahashi S,Nirasawa S,Sakuda S,Yasukawa K

更新日期：2015-07-01 00:00:00

abstract：:A new pyrrolidine derivative, (5S)-hydroxyethyl 2-oxopyrrolidine-5-carboxylate (1), a new flavonol glycoside, tamaraxetin 3,7-di-O-α-L-rhamnopyranoside (2), and a new triterpene saponin, polyscioside A methyl ester (3), along with six known compounds (4-9) were isolated from the leaves of Polyscias balfouriana. Their ...

journal_title：Journal of natural medicines

authors： Sugimoto S,Yamano Y,Khalil HE,Otsuka H,Kamel MS,Matsunami K

更新日期：2017-07-01 00:00:00

abstract：:Tetrandrine is a cytotoxic compound capable of exerting remarkable antitumor activity against many cancer cells in vitro and in vivo. However, little is known about its effect on human renal cell carcinoma (RCC). In the present study, using RCC 786-O, 769-P and ACHN cell lines as the model system, we demonstrated the ...

journal_title：Journal of natural medicines

authors： Chen T,Ji B,Chen Y

更新日期：2014-01-01 00:00:00

abstract：:Four hydrolyzable tannins [oenothein B (1), eugeniflorin D(2) (2), and tellimagrandins I (3) and II (4)], two related polyphenolic compounds [gallic acid (5) and quinic acid 3,5-di-O-gallate (6)], and four myricetin glycosides [myricetins 3-O-beta-D-xyloside (7), 3-O-beta-D-galactoside (8), 3-O-beta-D-galactoside 6''-...

journal_title：Journal of natural medicines

authors： Yoshimura M,Amakura Y,Tokuhara M,Yoshida T

更新日期：2008-07-01 00:00:00

abstract：:The evaluation of the antioxidant, anti-secretory and anti-inflammatory potentials of the ethyl acetate fraction (ELC) from the root bark of Lycium chinense against ethanol-induced gastric ulcer in mice and the possible mechanisms underlying this action was performed. The results indicated that oral administration of ...

journal_title：Journal of natural medicines

authors： Chen H,Olatunji OJ,Zhou Y

更新日期：2016-07-01 00:00:00

abstract：:Liver fibrosis is considered to be a result of chronic liver pathological changes, and hepatic stellate cells (HSCs) play an important role during this process. Evodiamine, an indole alkaloid derived from Evodia rutaecarpa, exhibits pharmacological activities. This study focused on the effects of evodiamine on carbon ...

journal_title：Journal of natural medicines

authors： Yang D,Li L,Qian S,Liu L

更新日期：2018-01-01 00:00:00

abstract：:Eight bastadins, tetramers of brominated-tyrosine derivatives, were isolated from the marine sponge Ianthella basta, and their anti-proliferative activities against endothelial cells were examined. A structure-activity relationship study of these compounds revealed that a macrocyclic structure was crucial, and a basta...

journal_title：Journal of natural medicines

authors： Aoki S,Cho SH,Hiramatsu A,Kotoku N,Kobayashi M

更新日期：2006-07-01 00:00:00

abstract：:The purpose of the study was to evaluate the suppressive effect of TJ-68 on duodenal spasms during endoscopic retrograde cholangiopancreatography (ERCP). At the point when the duodenal papilla was confirmed after insertion of the endoscope during ERCP, 5.0 g TJ-68 (Tsumura Co., Tokyo, Japan) was dissolved in 50 ml of ...

journal_title：Journal of natural medicines

authors： Sakai Y,Tsuyuguchi T,Ishihara T,Kato K,Tsuboi M,Ooka Y,Katsuura K,Ohara T,Takayama S,Kimura M,Kasanuki J,Ai M,Yokosuka O

更新日期：2009-04-01 00:00:00