Abstract：
:To date, there are very few effective drugs for liver fibrosis treatment; therefore, it is urgent to develop novel therapeutic targets and approaches. In the present research, we sought to study the protective effect of sweroside contained in Lonicera japonica or blue honeysuckle berries in a mouse model of liver fibrosis and investigate the underlying mechanism. The mouse model of liver fibrosis in was induced by intraperitoneal injections of 10% CCl4 for 6 weeks (three times/week). At the beginning of the fourth week, sweroside was intragastrically administered once a day and at the end of the treatment, biochemical and histological studies were investigated. The expression of FXR, miR-29a and the downstream targets were analyzed as well. Moreover, the effect of sweroside on cell proliferation was observed in human hepatic stellate cells (HSCs) (LX-2), along with using the siRNA for FXR and miR-29a inhibitor to investigate the underpinning of the anti-fibrotic effect of sweroside. Sweroside successfully protected the liver fibrosis in CCl4-induced mouse model, accompanied by miR-29a induction. Furthermore, sweroside also induced miR-29a in HSCs, resulting in the inhibition of COL1 and TIMP1. Our data also showed that either silencing miR-29a or knockdown of FXR in LX-2 cell abolished the inhibition of COL1 and TIMP1 as well as the inhibition of cell proliferation by sweroside treatment. In conclusion, sweroside exerted its anti-fibrotic effect in vivo and in vitro by up-regulation of miR-29a and repression of COL1 and TIMP1, which was at least in part through FXR.
journal_name
J Nat Medjournal_title
Journal of natural medicinesauthors
Gong J,Yang F,Yang Q,Tang X,Shu F,Xu L,Wang Z,Yang Ldoi
10.1007/s11418-019-01334-3subject
Has Abstractpub_date
2020-01-01 00:00:00pages
17-25issue
1eissn
1340-3443issn
1861-0293pii
10.1007/s11418-019-01334-3journal_volume
74pub_type
杂志文章abstract：:Celastrus orbiculatus is a medicinal plant belonging to the Celastraceae family. In this survey on the secondary metabolites of plants for obtaining antitumor substances, the chemical constituents of the stems of C. orbiculatus were investigated. Nortriptonoterpene (1), a new C19-norabietane diterpenoid, together with...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-019-01326-3
更新日期：2019-09-01 00:00:00
abstract：:Eurycomanone, an active constituent isolated from Eurycoma longifolia Jack, was examined for modulatory effects on cytochrome P450 (CYP) isoforms CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2C19, CYP2E1 and CYP3A4 using in vitro assays. The IC50 value was determined to assess the potencies of modulation for each CYP isoform. O...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-013-0794-8
更新日期：2014-04-01 00:00:00
abstract：:Taxol is produced by a few microorganisms and plants such as yew (Taxus sp.). Recent researches have shown that hazel (Corylus avellana L.) is also able to produce Taxol. In the present study, effects of different concentrations of phenylalanine (Phe) on the production of Taxol, antioxidant activity, and cytotoxic eff...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-012-0696-1
更新日期：2013-07-01 00:00:00
abstract：:Recruitment of immune cells to adipose tissue is altered dramatically in obesity, which results in chronic inflammation of the adipose tissue that leads to metabolic disorders, such as insulin resistance and type 2 diabetes mellitus. The regulation of immune cell infiltration into adipose tissue has prophylactic and t...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-019-01332-5
更新日期：2020-01-01 00:00:00
abstract：:Picrasma javanica Blume (Simaroubaceae) is a medium-sized tree that is distributed widely in tropical Asia. In our previous study, we isolated quassinoids from P. javanica bark collected in Myanmar, and reported their antiproliferative activities. In our ongoing research for the discovery of bioactive compounds from M...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-018-01279-z
更新日期：2019-06-01 00:00:00
abstract：:A new phenylethanoid, 1-O-β-D-(4-hydroxyphenyl)-ethyl-6-O-vanilloyl-glucopyranoside (1), and a new furofuran lignan, (7R,7'R,7''S,8S,8'S,8''R)-4', 4''-dihydroxy-3,3',3'',5-tetramethoxy-7,9':7'9-diepoxy-4,8''-oxy-8,8'-sesquineolignan-7'',9''-diol (2), along with five known compounds (3-7) were isolated from the roots o...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-016-0996-y
更新日期：2016-07-01 00:00:00
abstract：:I investigated the causative agents of licorice-induced pseudoaldosteronism, which is a frequent side effect of Japanese traditional Kampo medicines. Glycyrrhizin (GL), the main ingredient of licorice, is absorbed after being metabolized to glycyrrhetinic acid (GA) by intestinal bacteria, and then metabolized in liver...
journal_title：Journal of natural medicines
pub_type： 杂志文章,评审
doi：10.1007/s11418-021-01484-3
更新日期：2021-01-22 00:00:00
abstract：:The hydroalcoholic extract of fruits of Ziziphus jujuba (ZJ) was investigated for its anti-inflammatory effect using acute and chronic models of inflammation in rat. Wistar albino rats of either sex were employed in the present study (n = 6). Acute inflammation was induced by subplantar administration of carrageenan (...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-011-0531-0
更新日期：2011-07-01 00:00:00
abstract：:The core of solid tumors is characterized by hypoxia and a nutrient-starved microenvironment and has gained much attention as targets of anti-cancer drugs. In the course of search for selective growth inhibitors against the cancer cells adapted to nutrient starvation, epidithiodiketopiperazine DC1149B (1) together wit...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-019-01357-w
更新日期：2020-01-01 00:00:00
abstract：:We investigated the cytotoxicity of six neolignans (1-6), which are similar in structure to furanocyclohexenone with an angular allyl group, in human neuroblastoma cell lines (IMR-32, LA-N-1, NB-39, SK-N-SH) and normal cells [human umbilical vein endothelial cells (HUVEC) and human dermal fibroblasts (HDF)] using a 3-...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-011-0514-1
更新日期：2011-07-01 00:00:00
abstract：:Rosae fructus is a traditional Chinese crude drug, used for purgative purposes. It is included in the Japanese Pharmacopoeia XV, in which its origin is stated to be Rosa multiflora Thunberg. These days, some imported Rosae fructus are on the market and the pharmacological activity of the imported product is in questio...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-008-0293-5
更新日期：2009-01-01 00:00:00
abstract：:A new indole alkaloid, leucoridine A N-oxide (1), consisting of two units of a strychnan type of skeleton, was isolated from the leaves of Leuconotis griffithii. Its structure was elucidated by various spectroscopic means such as NMR and MS, and also by chemical means. Antiplasmodial activity against Plasmodium falcip...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-011-0574-2
更新日期：2012-04-01 00:00:00
abstract：:Four new Amaryllidaceae alkaloids (1-4) possessing a homolycorine-type or a crinine-type skeleton have been isolated from the aerial part of Zephyranthes candida, and their structures were elucidated on the basis of spectroscopic data. The stereochemistry was elucidated by combination of NOESY correlations and CD anal...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-014-0819-y
更新日期：2014-07-01 00:00:00
abstract：:Three new compounds, (3S)-dihydrobonducellin 8-O-β-D-glucopyranoside (1), 3',5'-dimethoxy-jezonolid (2), and latisilinoid (3), along with 16 known compounds, were isolated from the twigs of Caesalpinia latisiliqua (Leguminosae). The known compounds were identified as flavonoids, stilbenes, and phenolics as determined ...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-019-01335-2
更新日期：2020-01-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-015-0933-5
更新日期：2016-01-01 00:00:00
abstract：:Reversed-phase preparative high-performance liquid chromatography (HPLC) of the methanol extract of the aerial parts of Euphorbia petiolata Banks & Soland, an endemic Iranian medicinal plant, yielded ten free radical scavengers including eight flavonoid glycosides myricetin 3-O-glucoside (1), kaempferol 3-O-(2-O-gallo...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-009-0382-0
更新日期：2010-04-01 00:00:00
abstract：:Rhamnan sulfate (RS) is a polysaccharide with a rhamnose backbone isolated from Monostroma nitidum. Like heparin, it exerts anticoagulant activity in the presence of antithrombin. Endothelial cells facilitate the crosstalk between blood coagulation and vascular inflammation. In this study, we compared the effect of RS...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-019-01289-5
更新日期：2019-06-01 00:00:00
abstract：:Alkaline hydrolysis of the ether-insoluble resin glycoside (convolvulin) fraction of the seeds of Quamoclit × multifida (syn. Q. sloteri House, Convolvulaceae), a hybrid between Q. pennat and Q. coccinea, gave three new glycosidic acids (maltifidinic acids C, D, and E) along with three known glycosidic acids (quamocli...
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pub_type： 杂志文章
doi：10.1007/s11418-010-0464-z
更新日期：2011-01-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-012-0646-y
更新日期：2013-01-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-016-1051-8
更新日期：2017-01-01 00:00:00
abstract：:Four hydrolyzable tannins [oenothein B (1), eugeniflorin D(2) (2), and tellimagrandins I (3) and II (4)], two related polyphenolic compounds [gallic acid (5) and quinic acid 3,5-di-O-gallate (6)], and four myricetin glycosides [myricetins 3-O-beta-D-xyloside (7), 3-O-beta-D-galactoside (8), 3-O-beta-D-galactoside 6''-...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-008-0251-2
更新日期：2008-07-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-007-0224-x
更新日期：2008-04-01 00:00:00
abstract：:Since prostate growth is governed by the androgen signaling pathway, blockade of the pathway is regarded as an appropriate strategy for the treatment of benign prostatic hyperplasia (BPH). Panax ginseng is known to have various pharmacological activities. Of several products of its root, red ginseng, having many bioac...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-011-0609-8
更新日期：2012-07-01 00:00:00
abstract：:Two tetrahydroxanthones, 1,3,5S,8S-tetrahydroxy-5,6,7,8-tetrahydroxanthone (1) and 1,3,5R,8S-tetrahydroxy-5,6,7,8-tetrahydroxanthone (2), and six new tetrahydroxanthone glycosides, amarellins A-F (3-8), were isolated from the aerial parts of a Mongolian medicinal plant Gentianella amarella ssp. acuta (Gentianaceae). T...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-016-1015-z
更新日期：2016-10-01 00:00:00
abstract：:From the 1-BuOH-soluble fraction of a MeOH extract of the leaves of Guettarda speciosa L., two new compounds (1, 2) were isolated together with six known compounds. Spectroscopic analysis of 1 and 2 established their structures to be derivatives of a glycerol α-glucuronide and a megastigmane glycoside, respectively. H...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-010-0484-8
更新日期：2011-04-01 00:00:00
abstract：:Aged garlic extract (AGE), a garlic preparation rich in water-soluble cysteinyl moieties, has been reported to have multiple beneficial effects on cardiovascular disease including inhibition of platelet aggregation. However, the mode of AGE action on platelets has not been clear. In this study, we examined the effect ...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-016-1055-4
更新日期：2017-01-01 00:00:00
abstract：:Penta-O-galloyl-D-glucose (PGG) is a simple hydrolysable tannin in plants. PGG exists in two anomeric forms, α-PGG and β-PGG. While β-PGG can be found in a wide variety of plants, α-PGG is rather rare in nature. Numerous studies with β-PGG revealed a wide variety of biological activities, such as anti-microbial and an...
journal_title：Journal of natural medicines
pub_type： 杂志文章,评审
doi：10.1007/s11418-014-0823-2
更新日期：2014-07-01 00:00:00
abstract：:The aim of the study was to investigate the in vivo effect of the seashell protein Haishengsu (HSS) on Ehrlich ascites tumor. Mice were inoculated with Ehrlich ascites tumor cells and randomly divided into three HSS groups and a control group. The survival times in the three HSS-treated groups was longer than in the c...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-009-0346-4
更新日期：2009-10-01 00:00:00
abstract：:A novel, efficient, and accurate fingerprinting method using high performance liquid chromatography-photodiode array detection has been developed and optimized for the investigation and demonstration of the variance in chemical properties among Siraitia grosvenorii fruits from different origins. The effects of growth ...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-011-0555-5
更新日期：2012-01-01 00:00:00
abstract：:In our previous study, piperlonguminine from the fruit of Piper chaba was reported to promote adipogenesis in 3T3-L1 cells like the peroxisome proliferator-activated receptor-γ (PPARγ) agonist, troglitazone. In the present study, the mode of action of piperlonguminine in cells was examined. Piperlonguminine increased ...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-013-0770-3
更新日期：2014-01-01 00:00:00
