Abstract：
:A novel, efficient, and accurate fingerprinting method using high performance liquid chromatography-photodiode array detection has been developed and optimized for the investigation and demonstration of the variance in chemical properties among Siraitia grosvenorii fruits from different origins. The effects of growth stages, cultivated varieties, collection locations, and fruit portions of the herb on chromatographic fingerprints were examined. Eleven compounds were identified on chromatograms by comparing the retention time and UV spectrum of each peak separately with those of external references. The results revealed that chromatographic fingerprints, combining similarity or hierarchical clustering analysis along with reference compounds, could efficiently identify and distinguish S. grosvenorii fruits from different sources, which provided helpful clues for studying the plants' secondary metabolites and benefitted quality control.
journal_name
J Nat Medjournal_title
Journal of natural medicinesauthors
Lu F,Li D,Fu C,Liu J,Huang Y,Chen Y,Wen Y,Nohara Tdoi
10.1007/s11418-011-0555-5subject
Has Abstractpub_date
2012-01-01 00:00:00pages
70-6issue
1eissn
1340-3443issn
1861-0293journal_volume
66pub_type
杂志文章abstract：:A new arylbenzofuran, 4-hydroxy-2-(4'-hydroxy-2'-methoxyphenyl)-6-methoxybenzofu-ran-3-carbaldehyde (1), was isolated from the aerial parts of alfalfa (Medicago sativa L.), together with three known compounds. The structure of the new compound (1) was determined by spectroscopic methods. ...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-008-0297-1
更新日期：2009-04-01 00:00:00
abstract：:Three new compounds, citrusauranosides A (1), B (2), and C (3), along with 22 known compounds (4-25) were obtained from the 70% ethanol-water extract of the fruits of Citrus aurantium L.. Their structures were identified by spectroscopic methods. Among the known compounds, 14, 15, 17 and 23 were firstly obtained from ...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-018-1255-1
更新日期：2019-01-01 00:00:00
abstract：:Blood-brain barrier (BBB)-permeable components in the methanolic extract of Nelumbo nucifera flowers showed accelerative effects on neurite outgrowth in PC-12 cells. Among the constituents isolated from N. nucifera flowers in our previous study, aporphine-type alkaloids, lirinidine, asimilobine, N-methylasimilobine, a...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-019-01368-7
更新日期：2020-01-01 00:00:00
abstract：:Atherosclerosis is a major cause of coronary heart disease. As a result of the development of atherosclerotic lesions, the walls of blood vessels become thicker and inhibit blood circulation. Atherosclerosis is caused by a high-fat diet and vascular injury. Chronic arterial inflammation plays an important role in the ...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-018-1231-9
更新日期：2019-01-01 00:00:00
abstract：:Two new limonoids, sanjecumins A (1) and B (2), have been isolated from the leaves of Sandoricum koetjape, together with sandoripins A (3) and B (4). Their structures and absolute configurations were elucidated on the basis of NMR and CD data. Sandoripins A (3) and B (4) moderately inhibited nitric oxide production in...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-012-0677-4
更新日期：2013-04-01 00:00:00
abstract：:Mimosa pudica is used in traditional medicine for treating various disorders such as inflammatory conditions, diarrhoea, insomnia, alopecia, urogenital infections and wounds. The present study investigated the effect of M. pudica extract (MPE) on L-arginine-induced acute necrotising pancreatitis in rats. The ethanolic...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-016-0991-3
更新日期：2016-07-01 00:00:00
abstract：:A new phenylethanoid, 1-O-β-D-(4-hydroxyphenyl)-ethyl-6-O-vanilloyl-glucopyranoside (1), and a new furofuran lignan, (7R,7'R,7''S,8S,8'S,8''R)-4', 4''-dihydroxy-3,3',3'',5-tetramethoxy-7,9':7'9-diepoxy-4,8''-oxy-8,8'-sesquineolignan-7'',9''-diol (2), along with five known compounds (3-7) were isolated from the roots o...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-016-0996-y
更新日期：2016-07-01 00:00:00
abstract：:From the 1-BuOH-soluble fraction of a MeOH extract of Euphorbia hirta, collected in the Okinawa islands, three new megastigmane glucoside gallates, named hirtionosides A-C, 3-hydroxyoctanoic acid glucosides and a phenylpropanoid glucoside were isolated along with 15 known compounds. The structures of the new compounds...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-012-0692-5
更新日期：2013-04-01 00:00:00
abstract：:Ceramicines are a series of limonoids which were isolated from the bark of Malaysian Chisocheton ceramicus (Meliaceae) and show various biological activities. Ceramicine B, in particular, has been reported to show a strong lipid droplet accumulation (LDA) inhibitory activity on a mouse pre-adipocyte cell line (MC3T3-G...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-017-1109-2
更新日期：2018-01-01 00:00:00
abstract：:Autophagy is a catabolic process for degradation of intracellular components and plays an important role in the development and growth of cancer. Our preliminary screening confirmed that an extract from the root of Saussurea lappa remarkably suppressed the proliferation of HepG2 hepatocellular carcinoma cells and inhi...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-020-01462-1
更新日期：2021-01-01 00:00:00
abstract：:Aloperine (ALO), one of the alkaloids isolated from Sophora alopecuroides L., is traditionally used for various diseases including neuronal disorders. This study investigated the protective effects of ALO on neonatal rat primary-cultured hippocampal neurons injured by oxygen-glucose deprivation and reperfusion (OGD/RP...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-015-0928-2
更新日期：2015-10-01 00:00:00
abstract：:We have previously shown that the two sesquiterpene lactones, salograviolide A (Sal A) and iso-seco-tanapartholide (TNP), isolated from the Middle Eastern indigenous plants Centaurea ainetensis and Achillea falcata, respectively, possess selective antitumor properties. Here, we aimed to assess the anticancer effects o...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-012-0703-6
更新日期：2013-07-01 00:00:00
abstract：:(E)-methyl-4-hydroxy-3,5-dimethoxycinnamate, (E)-methyl-4-hydroxy-3-methoxycinnamate, (E)-methyl-4-hydroxycinnamate, (Z)-methyl-4-hydroxycinnamate, calycanthine, ursolic acid, 2-hydroxy-3-methylanthraquinone, 4-methoxybenzoic acid, 3,4,5-trimethoxybenzoic acid, methyl 4-hydroxybenzoate and allantoin were isolated from...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-008-0227-2
更新日期：2008-07-01 00:00:00
abstract：:In our previous study, piperlonguminine from the fruit of Piper chaba was reported to promote adipogenesis in 3T3-L1 cells like the peroxisome proliferator-activated receptor-γ (PPARγ) agonist, troglitazone. In the present study, the mode of action of piperlonguminine in cells was examined. Piperlonguminine increased ...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-013-0770-3
更新日期：2014-01-01 00:00:00
abstract：:Eight new furostanol glycosides (1-8), together with two known ones (9 and 10), have been isolated from a glycoside-enriched fraction prepared from the rhizomes of Helleborus orientalis (Ranunculaceae). The structures of 1-8 were determined on the basis of extensive spectroscopic analysis, including 2D NMR, and the re...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-010-0432-7
更新日期：2010-10-01 00:00:00
abstract：:Seven oleanane-type triterpene saponin bisdesmosides, perennisaponins N-T (1-7), were newly isolated from a methanol extract of daisy, the flowers of Bellis perennis L. (Asteraceae). The structures were determined based on chemical and physicochemical data and confirmed using previously isolated related compounds as r...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-016-0998-9
更新日期：2016-07-01 00:00:00
abstract：:Chresta martii (Asteraceae) is a plant found in the Xingó region (semi-arid area) in Northeastearn Brazil, and is recognized by the local population as a traditional herb used to treat gastric diseases. This is the first report of the chemical composition, acute toxicity, and gastroprotective effect in mice of the hyd...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-012-0663-x
更新日期：2013-01-01 00:00:00
abstract：:We investigated the cytotoxicity of six neolignans (1-6), which are similar in structure to furanocyclohexenone with an angular allyl group, in human neuroblastoma cell lines (IMR-32, LA-N-1, NB-39, SK-N-SH) and normal cells [human umbilical vein endothelial cells (HUVEC) and human dermal fibroblasts (HDF)] using a 3-...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-011-0514-1
更新日期：2011-07-01 00:00:00
abstract：:Evodiae fructus (EF), a fruit of Evodia rutaecarpa Bentham, has long been used as an analgesic drug in traditional Chinese and Japanese medicine. However, the underlying molecular mechanism of its pharmacological action is unclear. Here, using calcium imaging, whole-cell patch-clamp recording, and behavioral analysis,...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-015-0929-1
更新日期：2016-01-01 00:00:00
abstract：:In a previous study, we found that both synthetic 3-O-methylquercetin (3MQ) and 3,4',7-O-trimethylquercetin (34'7TMQ) increased extracellular melanin content. 34'7TMQ increased the activity of melanogenic enzymes by stimulating the p38 pathway and the expression of microphthalmia-associated transcription factor (MITF)...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-018-1175-0
更新日期：2018-03-01 00:00:00
abstract：:Euphorbia hirta L. has been widely used in India and Chinese society. The molecular pharmacology basis of its anti-inflammatory effect is revealed in this work. The ethanol extract of Euphorbia hirta L. (Eh) and its active component were studied in lipopolysaccharide (LPS)-activated macrophage cells (RAW 264.7) as an ...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-010-0417-6
更新日期：2010-07-01 00:00:00
abstract：:We screened water and methanol extracts of 28 Indonesian medicinal plants for their protein tyrosine phosphatase 1B (PTP1B) inhibitory activities. Nine water extracts, i.e., Alstonia scholaris leaf, Blumea balsamifera, Cinnamomum burmannii, Cymbopogon nardus, Melaleuca leucadendra, Phyllanthus niruri, Piper nigrum, Sy...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-012-0674-7
更新日期：2013-04-01 00:00:00
abstract：:Eurycomanone, an active constituent isolated from Eurycoma longifolia Jack, was examined for modulatory effects on cytochrome P450 (CYP) isoforms CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2C19, CYP2E1 and CYP3A4 using in vitro assays. The IC50 value was determined to assess the potencies of modulation for each CYP isoform. O...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-013-0794-8
更新日期：2014-04-01 00:00:00
abstract：:Advanced glycation end-products (AGEs) are associated with a non-enzymatic reaction between the amino group of a protein and the carbonyl group of a sugar during hyperglycemia. The precipitation of AGEs in different tissues leads to many complications, such as endothelial dysfunction, cardiovascular complications, ath...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-016-1051-8
更新日期：2017-01-01 00:00:00
abstract：:The purpose of the present study was to investigate the protective effects of combined therapy of garlic homogenate and hydrochlorothiazide (HCTZ) in animals with hypertension and myocardial damage. Three weeks of high fructose (10% w/v) in fluid to albino rats resulted in hypertension. They were subsequently administ...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-010-0467-9
更新日期：2011-01-01 00:00:00
abstract：:Two new xanthones namely cratochinone A (1) and cratochinone B (2), along with 16 known xanthones, were isolated from the roots of Cratoxylum cochinchinense. Their structures were characterized by spectroscopic methods, especially 1D and 2D NMR as well as comparison with those reported in the literature for known xant...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-019-01376-7
更新日期：2020-03-01 00:00:00
abstract：:Antihypertensive treatment is highly important to prevent the progression of chronic kidney disease. Shichimotsukokato (SKT), a traditional Japanese medicine (i.e., Kampo formula), lowered systolic blood pressure (SBP) in experimental animal models of hypertension. However, its mechanism of action has not been fully e...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-015-0945-1
更新日期：2016-04-01 00:00:00
abstract：:In vitro screening methods using cultured Neuro2a cells to examine the activation (phosphorylation) of extracellular signal-regulated kinase (ERK) 1/2 and promotion of neurite outgrowth revealed that the extracts of 5 Kampo (Japanese traditional) formulations have potential as medicines for the treatment of behavioral...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-017-1119-0
更新日期：2018-01-01 00:00:00
abstract：:Successive oral administration (50 mg/kg) of a 50% ethanolic extract (HP-ext) of devil's claw, the secondary root of Harpagophytum procumbens, showed a significant anti-inflammatory effect in the rat adjuvant-induced chronic arthritis model. HP-ext dose-dependently suppressed the lipopolysaccharide (LPS)-induced produ...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-010-0395-8
更新日期：2010-04-01 00:00:00
abstract：:A new depsidone, paucinervin Q (1), a new dichromone, paucinervin R (2), and a known compound, paucinervin B (3), were isolated from the stems of Garcinia paucinervis by various chromatographic methods. Their structures were determined by analysis of spectroscopic data. The isolates were evaluated for their antiprolif...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-018-1247-1
更新日期：2019-01-01 00:00:00
