Abstract：
:In a previous study, we found that both synthetic 3-O-methylquercetin (3MQ) and 3,4',7-O-trimethylquercetin (34'7TMQ) increased extracellular melanin content. 34'7TMQ increased the activity of melanogenic enzymes by stimulating the p38 pathway and the expression of microphthalmia-associated transcription factor (MITF). In contrast, 3MQ increased the activity of melanogenic enzymes without the involvement of MITF, which suggests that 3MQ inhibits the degradation of melanogenic enzymes. In the present study, we investigated the effects of 3MQ and 34'7TMQ on melanogenesis in normal human melanocytes and using a commercial three-dimensional (3D) skin model system. Both 3MQ and 34'7TMQ elongated the dendrites of normal human melanocytes from a Caucasian donor, but did not stimulate melanogenesis in the melanocytes. In the 3D skin model, which included melanocytes from an Asian donor, 3MQ and 34'7TMQ increased and elongated the melanocytes and showed a tendency to stimulate melanogenesis. These results suggest that 3MQ and 34'7TMQ could be put to practical use in skin care products and agents aimed at preventing hair graying.
journal_name
J Nat Medjournal_title
Journal of natural medicinesauthors
Yamauchi K,Mitsunaga Tdoi
10.1007/s11418-018-1175-0subject
Has Abstractpub_date
2018-03-01 00:00:00pages
563-569issue
2eissn
1340-3443issn
1861-0293pii
10.1007/s11418-018-1175-0journal_volume
72pub_type
杂志文章abstract：:The root of Angelica acutiloba Kitagawa is an important crude drug in Kampo medicines (traditional Japanese medicine). Chemical evaluation of crude drugs is crucial to ensuring the safety and efficacy of herbal medicine; however, there is currently no chemical standard for the A. acutiloba crude drug in Japanese pharm...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-018-1190-1
更新日期：2018-06-01 00:00:00
abstract：:In recent years, Spirulina has gained more and more attention from medical scientists as a nutraceutical and a source of potential pharmaceuticals. The present study was conducted to elucidate the immunomodulatory effect of Spirulina fusiformis (a cyanobacterium of the family Oscillatoriaceae) in vivo and in vitro. Th...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-008-0308-2
更新日期：2009-04-01 00:00:00
abstract：:Celastrus orbiculatus is a medicinal plant belonging to the Celastraceae family. In this survey on the secondary metabolites of plants for obtaining antitumor substances, the chemical constituents of the stems of C. orbiculatus were investigated. Nortriptonoterpene (1), a new C19-norabietane diterpenoid, together with...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-019-01326-3
更新日期：2019-09-01 00:00:00
abstract：:In vitro screening methods using cultured Neuro2a cells to examine the activation (phosphorylation) of extracellular signal-regulated kinase (ERK) 1/2 and promotion of neurite outgrowth revealed that the extracts of 5 Kampo (Japanese traditional) formulations have potential as medicines for the treatment of behavioral...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-017-1119-0
更新日期：2018-01-01 00:00:00
abstract：:Bioassay-guided fractionation led to the isolation of six new flavonol glycosides, floramanosides A (1), B (2), C (3), D (4), E (5), and F (6), from the flowers of Abelmouschus manihot. Their structures were elucidated by chemical and spectroscopic methods (UV, IR, HRESI-TOF-MS, 1D- and 2D-NMR). Activity screening res...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-012-0651-1
更新日期：2013-01-01 00:00:00
abstract：:From the dried rhizomes of Curcuma comosa cultivating in Thailand, 26 known sesquiterpenes were isolated: zederone, zederone epoxide, furanodienone, isofuranodienone, 1(10)Z,4Z-furanodiene-6-one, glechomanolide, dehydrocurdione, neocurdione, curdione, 7 alpha-hydroxyneocurdione, 7 beta-hydroxycurdione, germacrone-1(10...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-008-0282-8
更新日期：2009-01-01 00:00:00
abstract：:We have previously shown that the two sesquiterpene lactones, salograviolide A (Sal A) and iso-seco-tanapartholide (TNP), isolated from the Middle Eastern indigenous plants Centaurea ainetensis and Achillea falcata, respectively, possess selective antitumor properties. Here, we aimed to assess the anticancer effects o...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-012-0703-6
更新日期：2013-07-01 00:00:00
abstract：:A new pyrrolidine derivative, (5S)-hydroxyethyl 2-oxopyrrolidine-5-carboxylate (1), a new flavonol glycoside, tamaraxetin 3,7-di-O-α-L-rhamnopyranoside (2), and a new triterpene saponin, polyscioside A methyl ester (3), along with six known compounds (4-9) were isolated from the leaves of Polyscias balfouriana. Their ...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-017-1081-x
更新日期：2017-07-01 00:00:00
abstract：:Several studies have indicated the involvement of oxidative stress and high glucose-induced cell death in the development of diabetic neuropathy. Satureja khuzestanica has been recommended in the literature as a remedy for the treatment of diabetes, and also contains antioxidant agents. Here, we investigated the possi...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-012-0646-y
更新日期：2013-01-01 00:00:00
abstract：:A new oxygenated lanostane-type triterpene, named lucidumol C, together with six known compounds, was isolated from the chloroform extract of the fruiting bodies of Ganoderma lingzhi. Structures were established based on extensive spectroscopic and chemical studies. Potential cytotoxic activities of the isolated compo...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-016-0976-2
更新日期：2016-07-01 00:00:00
abstract：:Reversed-phase preparative high-performance liquid chromatography (HPLC) of the methanol extract of the aerial parts of Euphorbia petiolata Banks & Soland, an endemic Iranian medicinal plant, yielded ten free radical scavengers including eight flavonoid glycosides myricetin 3-O-glucoside (1), kaempferol 3-O-(2-O-gallo...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-009-0382-0
更新日期：2010-04-01 00:00:00
abstract：:Ceramicines are a series of limonoids which were isolated from the bark of Malaysian Chisocheton ceramicus (Meliaceae) and show various biological activities. Ceramicine B, in particular, has been reported to show a strong lipid droplet accumulation (LDA) inhibitory activity on a mouse pre-adipocyte cell line (MC3T3-G...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-017-1109-2
更新日期：2018-01-01 00:00:00
abstract：:Atherosclerosis is a major cause of coronary heart disease. As a result of the development of atherosclerotic lesions, the walls of blood vessels become thicker and inhibit blood circulation. Atherosclerosis is caused by a high-fat diet and vascular injury. Chronic arterial inflammation plays an important role in the ...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-018-1231-9
更新日期：2019-01-01 00:00:00
abstract：:It is generally accepted that fungi have a number of dormant gene clusters for the synthesis of secondary metabolites, and the activation of these gene clusters can expand the diversity of secondary metabolites in culture. Recent studies have revealed that the mycolic acid-containing bacterium Tsukamurella pulmonis ac...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-019-01345-0
更新日期：2020-01-01 00:00:00
abstract：:This study reports on the determination of 11 elements in 33 medicinal plants from Sudan and discusses a possible correlation between their curative effects and their trace elements content. Further, a possible accumulation of adverse heavy metals could be excluded. A total of 11 elements (cadmium, lead, mercury, tin,...
journal_title：Journal of natural medicines
pub_type： 信件
doi：10.1007/s11418-012-0630-6
更新日期：2012-10-01 00:00:00
abstract：:An acyclic diterpene (plaunotol; 1) and two furanoditerpenes (plaunolide, 2 and plaunol E, 3), were isolated from Croton stellatopilosus leaves, and assessed for their inhibitory activity on nitric oxide (NO) production by lipopolysaccharide (LPS)-induced RAW264.7 cells. Plaunotol, plaunolide and plaunol E exhibited i...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-012-0668-5
更新日期：2013-01-01 00:00:00
abstract：:Picrorhiza kurrooa Royle ex Benth (Scrophulariaceae), commonly known as Kutki, is a major ingredient of many ayurvedic preparations prescribed in the treatment of various diseases. Picrosides I and II are the active agents responsible for the medicinal effects of Kutki, and the variation in content of these compounds ...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-010-0491-9
更新日期：2011-07-01 00:00:00
abstract：:Although Radix Angelicae dahuricae (Angelica) has been traditionally used in patients with rheumatism arthralgia, its bioactive ingredients remain to be determined. In this study, the essential oil extract of Radix Angelicae dahuricae (EOAD) was assessed for its anti-inflammatory activities against xylene-induced acut...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-016-0978-0
更新日期：2016-07-01 00:00:00
abstract：:From the 1-BuOH-soluble fraction of a MeOH extract of the leaves of Guettarda speciosa L., two new compounds (1, 2) were isolated together with six known compounds. Spectroscopic analysis of 1 and 2 established their structures to be derivatives of a glycerol α-glucuronide and a megastigmane glycoside, respectively. H...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-010-0484-8
更新日期：2011-04-01 00:00:00
abstract：:This investigation was aimed to probe the pharmacological base of medicinal use of Acorus calamus in ischemic heart diseases. Effect on heart parameters was studied in isolated rabbit heart while coronary vasodilator effect was studied in isolated bovine coronary arterial rings, suspended in tissue baths filled with K...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-011-0561-7
更新日期：2012-01-01 00:00:00
abstract：:Agarwood oil and spikenard extract were examined for their sedative activity using a spontaneous vapor administration system. It was shown that inhalation of agarwood oil vapor sedated mice. The main volatile constituents of the oil were found to be benzylacetone [agarwood oil from a Hong Kong market (1)], or alpha-gu...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-007-0177-0
更新日期：2008-01-01 00:00:00
abstract：:Blood-brain barrier (BBB)-permeable components in the methanolic extract of Nelumbo nucifera flowers showed accelerative effects on neurite outgrowth in PC-12 cells. Among the constituents isolated from N. nucifera flowers in our previous study, aporphine-type alkaloids, lirinidine, asimilobine, N-methylasimilobine, a...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-019-01368-7
更新日期：2020-01-01 00:00:00
abstract：:It has been found by ribosomal DNA analysis that the endophytic filamentous fungi isolated from the tea plant Camellia sinensis (Theaceae) are composed of six groups; one Fusarium sp., one Penicillium sp., two Schizophyllum sp., and two Diaporthe sp.. ...
journal_title：Journal of natural medicines
pub_type： 社论
doi：10.1007/s11418-006-0038-2
更新日期：2006-07-01 00:00:00
abstract：:Crude extract of Juniperus excelsa (JeExt), which tested positive for the presence of anthraquinone, flavonoids, saponins, sterols, terpenes and tannin, exhibited a protective effect against castor oil-induced diarrhoea in mice at 100-1000 mg/kg. In rabbit jejunum preparations, JeExt (0.01-1.0 mg/mL) caused relaxation...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-011-0605-z
更新日期：2012-04-01 00:00:00
abstract：:The present study aimed at investigating the effect of carvacrol on hepatic mitochondrial enzyme activities and DNA damage in D: -galactosamine (D: -GalN)-induced hepatotoxicity in male albino Wistar rats. The activities of hepatic mitochondrial enzymes such as isocitrate dehydrogenase, α-ketoglutarate dehydrogenase, ...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-011-0544-8
更新日期：2011-07-01 00:00:00
abstract：:We aimed to establish a methodology for identifying Paeonia samples based on metallomic analysis. We prepared 66 batches of samples (16 batches of crude drugs and 50 batches of cultivars, comprising 64 batches of Paeonia lactiflora and 2 batches of P. veitchii) collected from Japan and China (Inner Mongolia and elsewh...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-013-0795-7
更新日期：2014-04-01 00:00:00
abstract：:This experiment's with aim was to study the pharmacokinetics of asperosaponin VI and its three metabolites (cauloside A, HN saponin F and hederagenin) via a sensitive high performance liquid chromatography connected with electrospray ionization triple quadrupole mass spectrum (HPLC-ESI-MS/MS). Chromatographic separati...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-014-0821-4
更新日期：2014-07-01 00:00:00
abstract：:A new aromatic derivative, 5-(3,4-dihydroxyphenyl)-3-methylcyclohex-2-enone (1), and three known compounds, peltigerine, solorinine, and phenyl butanoid, were isolated from the MeOH extract of the lichen Peltigera dolichorrhiza (Peltigeraceae). Their structures were determined by 1D and 2D nuclear magnetic resonance a...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-010-0409-6
更新日期：2010-07-01 00:00:00
abstract：:Eight new furostanol glycosides (1-8), together with two known ones (9 and 10), have been isolated from a glycoside-enriched fraction prepared from the rhizomes of Helleborus orientalis (Ranunculaceae). The structures of 1-8 were determined on the basis of extensive spectroscopic analysis, including 2D NMR, and the re...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-010-0432-7
更新日期：2010-10-01 00:00:00
abstract：:Poria, a dried sclerotium of Wolfiporia cocos Ryvarden et Gilbertson (Polyporaceae) has been used as a crude drug in both Chinese and Japanese (Kampo) traditional medicines. Recently, cultivated products of Chinese Poria strains have accounted for most of the market, while the cultivation of Ja...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-011-0612-0
更新日期：2012-07-01 00:00:00
