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Anti-inflammatory activity of diterpenes from Croton stellatopilosus on LPS-induced RAW264.7 cells.

Abstract：

:An acyclic diterpene (plaunotol; 1) and two furanoditerpenes (plaunolide, 2 and plaunol E, 3), were isolated from Croton stellatopilosus leaves, and assessed for their inhibitory activity on nitric oxide (NO) production by lipopolysaccharide (LPS)-induced RAW264.7 cells. Plaunotol, plaunolide and plaunol E exhibited inhibitory activity with IC(50) values of 3.41, 17.09 and 2.79 μM, respectively. Cytotoxic effects were observed at concentrations of ≥100 μM for plaunotol and ≥10 μM for plaunol E. In order to understand the mechanism of this anti-inflammatory activity, transcription profiles of the COX-1, COX-2 and iNOS genes were measured using a quantitative RT-PCR technique. The level of gene expression was expressed as a relative quantitation according to the comparative C (T) method. The results indicated that plaunotol stimulated the COX-1 and COX-2 genes, and suppressed expression of the iNOS gene. Treatment of cells with plaunolide caused a downregulation of the expressions of the COX-1, COX-2 and iNOS genes. In contrast, plaunol E inhibited the expression of the COX-2, stimulated COX-1 and iNOS expressions. In summary, the present study shows that different diterpenes from C. stellatopilosus leaves exhibit anti-inflammatory activity towards LPS-activated RAW264.7 cells by different mechanisms. Our results provide data to support further investigations into the possibility that these diterpenes could be alternatives to act as anti-inflammatory agents.

journal_name

J Nat Med

journal_title

Journal of natural medicines

authors

Premprasert C,Tewtrakul S,Plubrukarn A,Wungsintaweekul J

doi

10.1007/s11418-012-0668-5

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

174-81

issue

1

eissn

1340-3443

issn

1861-0293

journal_volume

67

pub_type

杂志文章

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