Abstract：
:Celastrus orbiculatus is a medicinal plant belonging to the Celastraceae family. In this survey on the secondary metabolites of plants for obtaining antitumor substances, the chemical constituents of the stems of C. orbiculatus were investigated. Nortriptonoterpene (1), a new C19-norabietane diterpenoid, together with six other known abietane-type diterpenoids (2-7) and five known kaurane-type diterpenoids (8-12) were isolated and identified from the EtOAc extract of C. orbiculatus. Their structures were elucidated on the basis of extensive spectroscopic methods, including UV, IR, HR-ESI-MS, ECD, and NMR experiments, and by comparison with literature data. Compound 1 is a new C19-norabietane diterpenoid with 19 carbons. All compounds except for 10 and 11 were isolated from C. orbiculatus for the first time. The NMR data of 9 were reported for the first time. Compounds 1, 7 and 11 showed cytotoxicities against SGC-7901 with IC50 values of 63.2, 80.9 and 56.7 μM, respectively.
journal_name
J Nat Medjournal_title
Journal of natural medicinesauthors
Jiang W,Shan TZ,Xu JJ,Chen WJ,Miao L,Lv MY,Tao L,Liu YQdoi
10.1007/s11418-019-01326-3subject
Has Abstractpub_date
2019-09-01 00:00:00pages
841-846issue
4eissn
1340-3443issn
1861-0293pii
10.1007/s11418-019-01326-3journal_volume
73pub_type
杂志文章abstract：:We screened water and methanol extracts of 28 Indonesian medicinal plants for their protein tyrosine phosphatase 1B (PTP1B) inhibitory activities. Nine water extracts, i.e., Alstonia scholaris leaf, Blumea balsamifera, Cinnamomum burmannii, Cymbopogon nardus, Melaleuca leucadendra, Phyllanthus niruri, Piper nigrum, Sy...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-012-0674-7
更新日期：2013-04-01 00:00:00
abstract：:Crude extract of Juniperus excelsa (JeExt), which tested positive for the presence of anthraquinone, flavonoids, saponins, sterols, terpenes and tannin, exhibited a protective effect against castor oil-induced diarrhoea in mice at 100-1000 mg/kg. In rabbit jejunum preparations, JeExt (0.01-1.0 mg/mL) caused relaxation...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-011-0605-z
更新日期：2012-04-01 00:00:00
abstract：:Species of genus Ocimum (Lamiaceae) are economically important due to their essential oils and utilization as medicine for many disorders, including the central nervous system. A previous study showed seasonal variations in chemical profile and in central nervous system activities of essential oil from Ocimum gratissi...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-010-0429-2
更新日期：2010-10-01 00:00:00
abstract：:The present study was designed to determine the protective effects of Yucca schidigera (Ys) against oxidative damage induced by acute nitrite intoxication as well as the histopathological evaluation of Ys in rats. The rats were divided into three groups each containing 12 rats: control (C); nitrite intoxication (N); Y...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-009-0338-4
更新日期：2009-07-01 00:00:00
abstract：:From the 1-BuOH-soluble fraction of a MeOH extract of Euphorbia hirta, collected in the Okinawa islands, three new megastigmane glucoside gallates, named hirtionosides A-C, 3-hydroxyoctanoic acid glucosides and a phenylpropanoid glucoside were isolated along with 15 known compounds. The structures of the new compounds...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-012-0692-5
更新日期：2013-04-01 00:00:00
abstract：:The root of Angelica acutiloba Kitagawa is an important crude drug in Kampo medicines (traditional Japanese medicine). Chemical evaluation of crude drugs is crucial to ensuring the safety and efficacy of herbal medicine; however, there is currently no chemical standard for the A. acutiloba crude drug in Japanese pharm...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-018-1190-1
更新日期：2018-06-01 00:00:00
abstract：:Rhamnan sulfate (RS) is a polysaccharide with a rhamnose backbone isolated from Monostroma nitidum. Like heparin, it exerts anticoagulant activity in the presence of antithrombin. Endothelial cells facilitate the crosstalk between blood coagulation and vascular inflammation. In this study, we compared the effect of RS...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-019-01289-5
更新日期：2019-06-01 00:00:00
abstract：:Solvent partitioning followed by column chromatography of the MeOH extract of the seeds of Swietenia mahagoni afforded two limonoids, swietenolide (1) and 2-hydroxy-3-O-tigloylswietenolide (2). The compounds were identified by spectroscopic means. The antibacterial activity of these compounds was assessed against eigh...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-008-0287-3
更新日期：2009-01-01 00:00:00
abstract：:Recruitment of immune cells to adipose tissue is altered dramatically in obesity, which results in chronic inflammation of the adipose tissue that leads to metabolic disorders, such as insulin resistance and type 2 diabetes mellitus. The regulation of immune cell infiltration into adipose tissue has prophylactic and t...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-019-01332-5
更新日期：2020-01-01 00:00:00
abstract：:A new indole alkaloid, leucoridine A N-oxide (1), consisting of two units of a strychnan type of skeleton, was isolated from the leaves of Leuconotis griffithii. Its structure was elucidated by various spectroscopic means such as NMR and MS, and also by chemical means. Antiplasmodial activity against Plasmodium falcip...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-011-0574-2
更新日期：2012-04-01 00:00:00
abstract：:Phytochemical investigation of the methanol extract of Vitex limonifolia leaves led to the isolation of three new labdane-type diterpenoids, vitexlimolides A-C (1-3) and eight known compounds, 5,4'-dihydroxy-3,7-dimethoxyflavone (4), vitecetin (5), 5,4'-dihydroxy-7,3'-dimethoxyflavone (6), verrucosin (7), 2α, 3α-dihyd...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-017-1125-2
更新日期：2018-01-01 00:00:00
abstract：:I investigated the causative agents of licorice-induced pseudoaldosteronism, which is a frequent side effect of Japanese traditional Kampo medicines. Glycyrrhizin (GL), the main ingredient of licorice, is absorbed after being metabolized to glycyrrhetinic acid (GA) by intestinal bacteria, and then metabolized in liver...
journal_title：Journal of natural medicines
pub_type： 杂志文章,评审
doi：10.1007/s11418-021-01484-3
更新日期：2021-01-22 00:00:00
abstract：:Oligostilbenoids are a group of natural products derived from the oxidative coupling of C6-C2-C6 units found in some plant families. A structurally diverse chemical pool is produced after the successive regioselective and stereoselective oligomerization of resveratrol. This review describes the current status and know...
journal_title：Journal of natural medicines
pub_type： 杂志文章,评审
doi：10.1007/s11418-020-01412-x
更新日期：2020-09-01 00:00:00
abstract：:Shakuyakukanzoto (SKT) is a kampo medicine composed of equal proportions of Glycyrrhizae radix (G. radix) and Paeoniae radix (P. radix). A double-blind study reported that SKT significantly ameliorated painful muscle cramp in cirrhosis patients without the typical severe side effects of muscle weakness and central ner...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-015-0890-z
更新日期：2015-07-01 00:00:00
abstract：:Successive oral administration (50 mg/kg) of a 50% ethanolic extract (HP-ext) of devil's claw, the secondary root of Harpagophytum procumbens, showed a significant anti-inflammatory effect in the rat adjuvant-induced chronic arthritis model. HP-ext dose-dependently suppressed the lipopolysaccharide (LPS)-induced produ...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-010-0395-8
更新日期：2010-04-01 00:00:00
abstract：:Six cycloartane glycosides, named tareciliosides N-S, and a known iridoid glucoside, ixoroside, were isolated in further extensive studies on the 1-BuOH-soluble fraction of a MeOH extract of the leaves of Tarenna gracilipes. From the EtOAc-soluble fraction, three known triterpenes were isolated. Their toxicities towar...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-012-0707-2
更新日期：2013-07-01 00:00:00
abstract：:Aloperine (ALO), one of the alkaloids isolated from Sophora alopecuroides L., is traditionally used for various diseases including neuronal disorders. This study investigated the protective effects of ALO on neonatal rat primary-cultured hippocampal neurons injured by oxygen-glucose deprivation and reperfusion (OGD/RP...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-015-0928-2
更新日期：2015-10-01 00:00:00
abstract：:A methanolic extract of Argusia (or Messerschmidia or Tournefortia) argentea (Boraginaceae) significantly inhibited hemorrhage induced by crude venom of Trimeresurus flavoviridis. The extract was then separated according to antivenom activity by using silica gel column chromatography and HPLC equipped with an octadecy...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-010-0428-3
更新日期：2010-10-01 00:00:00
abstract：:In this study, we analyzed the CYP3A inhibitory components of star fruit Averrhoa carambola L., using liquid chromatography-mass spectrometry (LC-MS). The stereoisomer of procyanidin B1 and B2 and/or the trimer consisting of catechin and/or epicatechin were suggested to be potent inhibitory components. ...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-008-0239-y
更新日期：2008-07-01 00:00:00
abstract：:Agarwood oil and spikenard extract were examined for their sedative activity using a spontaneous vapor administration system. It was shown that inhalation of agarwood oil vapor sedated mice. The main volatile constituents of the oil were found to be benzylacetone [agarwood oil from a Hong Kong market (1)], or alpha-gu...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-007-0177-0
更新日期：2008-01-01 00:00:00
abstract：:The present study aimed at investigating the effect of carvacrol on hepatic mitochondrial enzyme activities and DNA damage in D: -galactosamine (D: -GalN)-induced hepatotoxicity in male albino Wistar rats. The activities of hepatic mitochondrial enzymes such as isocitrate dehydrogenase, α-ketoglutarate dehydrogenase, ...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-011-0544-8
更新日期：2011-07-01 00:00:00
abstract：:Although Radix Angelicae dahuricae (Angelica) has been traditionally used in patients with rheumatism arthralgia, its bioactive ingredients remain to be determined. In this study, the essential oil extract of Radix Angelicae dahuricae (EOAD) was assessed for its anti-inflammatory activities against xylene-induced acut...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-016-0978-0
更新日期：2016-07-01 00:00:00
abstract：:Five new compounds, rigenolides D-H (1-5), were isolated from the aerial parts of Gentiana rigescens Franch. Their structures were assigned by detailed spectroscopic analyses and chemical conversions. Rigenolides D (1) and E (2) were elucidated to be a secoiridoid and a norsecoiridoid, respectively, possessing a dieno...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-018-1181-2
更新日期：2018-03-01 00:00:00
abstract：:Rosae fructus is a traditional Chinese crude drug, used for purgative purposes. It is included in the Japanese Pharmacopoeia XV, in which its origin is stated to be Rosa multiflora Thunberg. These days, some imported Rosae fructus are on the market and the pharmacological activity of the imported product is in questio...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-008-0293-5
更新日期：2009-01-01 00:00:00
abstract：:Five new coumarins, (+)-peujaponisin (1) and multivittans A-D (2-5), were isolated from the roots of Ligusticum multivittatum Franch., and their structures were established by spectral means. ...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-007-0193-0
更新日期：2008-01-01 00:00:00
abstract：:We aimed to establish a methodology for identifying Paeonia samples based on metallomic analysis. We prepared 66 batches of samples (16 batches of crude drugs and 50 batches of cultivars, comprising 64 batches of Paeonia lactiflora and 2 batches of P. veitchii) collected from Japan and China (Inner Mongolia and elsewh...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-013-0795-7
更新日期：2014-04-01 00:00:00
abstract：:In our previous study, piperlonguminine from the fruit of Piper chaba was reported to promote adipogenesis in 3T3-L1 cells like the peroxisome proliferator-activated receptor-γ (PPARγ) agonist, troglitazone. In the present study, the mode of action of piperlonguminine in cells was examined. Piperlonguminine increased ...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-013-0770-3
更新日期：2014-01-01 00:00:00
abstract：:Five polyphenolic compounds were identified from the diethyl ether and ethyl acetate extracts of the herb of ragged robin, Lychnis flos-cuculi L. (Caryophyllaceae). The identified and isolated compounds were established as a caffeic acid, luteolin, apigenin, apigenin 8-C-beta-D-glucopyranoside (vitexin) and luteolin 8...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-008-0261-0
更新日期：2008-10-01 00:00:00
abstract：:Euphorbia hirta L. has been widely used in India and Chinese society. The molecular pharmacology basis of its anti-inflammatory effect is revealed in this work. The ethanol extract of Euphorbia hirta L. (Eh) and its active component were studied in lipopolysaccharide (LPS)-activated macrophage cells (RAW 264.7) as an ...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-010-0417-6
更新日期：2010-07-01 00:00:00
abstract：:Seven oleanane-type triterpene saponin bisdesmosides, perennisaponins N-T (1-7), were newly isolated from a methanol extract of daisy, the flowers of Bellis perennis L. (Asteraceae). The structures were determined based on chemical and physicochemical data and confirmed using previously isolated related compounds as r...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-016-0998-9
更新日期：2016-07-01 00:00:00
