Antibacterial activity of two limonoids from Swietenia mahagoni against multiple-drug-resistant (MDR) bacterial strains.

abstract：:Four new Amaryllidaceae alkaloids (1-4) possessing a homolycorine-type or a crinine-type skeleton have been isolated from the aerial part of Zephyranthes candida, and their structures were elucidated on the basis of spectroscopic data. The stereochemistry was elucidated by combination of NOESY correlations and CD anal...

journal_title：Journal of natural medicines

authors： Shitara N,Hirasawa Y,Hasumi S,Sasaki T,Matsumoto M,Wong CP,Kaneda T,Asakawa Y,Morita H

更新日期：2014-07-01 00:00:00

abstract：:In our previous study, piperlonguminine from the fruit of Piper chaba was reported to promote adipogenesis in 3T3-L1 cells like the peroxisome proliferator-activated receptor-γ (PPARγ) agonist, troglitazone. In the present study, the mode of action of piperlonguminine in cells was examined. Piperlonguminine increased ...

journal_title：Journal of natural medicines

authors： Yamaguchi I,Matsuda H,Zhang H,Hamao M,Yamashita C,Kogami Y,Kon'I H,Murata M,Nakamura S,Yoshikawa M

更新日期：2014-01-01 00:00:00

abstract：:The purpose of the present study was to investigate the protective effects of combined therapy of garlic homogenate and hydrochlorothiazide (HCTZ) in animals with hypertension and myocardial damage. Three weeks of high fructose (10% w/v) in fluid to albino rats resulted in hypertension. They were subsequently administ...

journal_title：Journal of natural medicines

authors： Asdaq SM,Inamdar MN

更新日期：2011-01-01 00:00:00

abstract：:Five new compounds, rigenolides D-H (1-5), were isolated from the aerial parts of Gentiana rigescens Franch. Their structures were assigned by detailed spectroscopic analyses and chemical conversions. Rigenolides D (1) and E (2) were elucidated to be a secoiridoid and a norsecoiridoid, respectively, possessing a dieno...

journal_title：Journal of natural medicines

authors： Suyama Y,Tanaka N,Kawazoe K,Murakami K,Li SL,Sun HD,Kashiwada Y

更新日期：2018-03-01 00:00:00

abstract：:Four hydrolyzable tannins [oenothein B (1), eugeniflorin D(2) (2), and tellimagrandins I (3) and II (4)], two related polyphenolic compounds [gallic acid (5) and quinic acid 3,5-di-O-gallate (6)], and four myricetin glycosides [myricetins 3-O-beta-D-xyloside (7), 3-O-beta-D-galactoside (8), 3-O-beta-D-galactoside 6''-...

journal_title：Journal of natural medicines

authors： Yoshimura M,Amakura Y,Tokuhara M,Yoshida T

更新日期：2008-07-01 00:00:00

abstract：:Cancer cachexia is a complex and multifactorial syndrome that influences about 50-80% of cancer patients and may lead to 20% of cancer deaths and muscle atrophy is the key characteristic of the syndrome. Recent researches have shown that myostatin is a negative regulator in the growth and differentiation of skeletal m...

journal_title：Journal of natural medicines

authors： Ge Z,Liu D,Shang Y,Li Y,Chen SZ

更新日期：2020-09-01 00:00:00

abstract：:Celastrus orbiculatus is a medicinal plant belonging to the Celastraceae family. In this survey on the secondary metabolites of plants for obtaining antitumor substances, the chemical constituents of the stems of C. orbiculatus were investigated. Nortriptonoterpene (1), a new C19-norabietane diterpenoid, together with...

journal_title：Journal of natural medicines

authors： Jiang W,Shan TZ,Xu JJ,Chen WJ,Miao L,Lv MY,Tao L,Liu YQ

更新日期：2019-09-01 00:00:00

abstract：:Fufang Xueshuantong Capsule (FXST) can reduce urinary albumin and whole blood viscosity in early diabetic nephropathy (DN) patients. This research aimed to investigate the effect of FXST on kidney function in DN rats and to identify the underlying molecular mechanisms. We performed Illumina RatRef-12 Expression BeadCh...

journal_title：Journal of natural medicines

authors： Zhang Q,Xiao X,Li M,Li W,Yu M,Zhang H,Sun X,Mao L,Xiang H

更新日期：2013-01-01 00:00:00

abstract：:We aimed to establish a methodology for identifying Paeonia samples based on metallomic analysis. We prepared 66 batches of samples (16 batches of crude drugs and 50 batches of cultivars, comprising 64 batches of Paeonia lactiflora and 2 batches of P. veitchii) collected from Japan and China (Inner Mongolia and elsewh...

journal_title：Journal of natural medicines

authors： Shimada K,Nakamura Y,Kawase M,Komatsu K,Saito T,Takahashi K

更新日期：2014-04-01 00:00:00

abstract：:The root of Angelica acutiloba Kitagawa is an important crude drug in Kampo medicines (traditional Japanese medicine). Chemical evaluation of crude drugs is crucial to ensuring the safety and efficacy of herbal medicine; however, there is currently no chemical standard for the A. acutiloba crude drug in Japanese pharm...

journal_title：Journal of natural medicines

authors： Shinjyo N,Fuchino H,Kawahara N,Hishida A

更新日期：2018-06-01 00:00:00

abstract：:This investigation was aimed to probe the pharmacological base of medicinal use of Acorus calamus in ischemic heart diseases. Effect on heart parameters was studied in isolated rabbit heart while coronary vasodilator effect was studied in isolated bovine coronary arterial rings, suspended in tissue baths filled with K...

journal_title：Journal of natural medicines

authors： Shah AJ,Gilani AH

更新日期：2012-01-01 00:00:00

abstract：:A new aromatic derivative, 5-(3,4-dihydroxyphenyl)-3-methylcyclohex-2-enone (1), and three known compounds, peltigerine, solorinine, and phenyl butanoid, were isolated from the MeOH extract of the lichen Peltigera dolichorrhiza (Peltigeraceae). Their structures were determined by 1D and 2D nuclear magnetic resonance a...

journal_title：Journal of natural medicines

authors： Yoshikawa K,Kunioka E,Kokudo N,Hashimoto T

更新日期：2010-07-01 00:00:00

abstract：:Taxol is produced by a few microorganisms and plants such as yew (Taxus sp.). Recent researches have shown that hazel (Corylus avellana L.) is also able to produce Taxol. In the present study, effects of different concentrations of phenylalanine (Phe) on the production of Taxol, antioxidant activity, and cytotoxic eff...

journal_title：Journal of natural medicines

authors： Bemani E,Ghanati F,Rezaei A,Jamshidi M

更新日期：2013-07-01 00:00:00

abstract：:We investigated the cytotoxicity of six neolignans (1-6), which are similar in structure to furanocyclohexenone with an angular allyl group, in human neuroblastoma cell lines (IMR-32, LA-N-1, NB-39, SK-N-SH) and normal cells [human umbilical vein endothelial cells (HUVEC) and human dermal fibroblasts (HDF)] using a 3-...

journal_title：Journal of natural medicines

authors： Hayama T,Tabata K,Uchiyama T,Fujimoto Y,Suzuki T

更新日期：2011-07-01 00:00:00

abstract：:Twenty-three new C21 steroidal glycosides, marstenacissides C1-C10 (1-10), D1-D7 (11-17) and E1-E6 (18-23), and four new C21 steroids, 11α,12β-O-ditigloyl-tenacigenin C (24), 11α-O-benzoyl-12β-O-tigloyl-tenacigenin C (25), 11α-O-tigloyl-12β-O-benzoyl-tenacigenin C (26) and 11α-O-tigloyl-12β-O-benzoyl-marsdenin (27), w...

journal_title：Journal of natural medicines

authors： Pang X,Kang LP,Fang XM,Yu HS,Han LF,Zhao Y,Zhang LX,Yu LY,Ma BP

更新日期：2018-01-01 00:00:00

abstract：:Rhamnan sulfate (RS) is a polysaccharide with a rhamnose backbone isolated from Monostroma nitidum. Like heparin, it exerts anticoagulant activity in the presence of antithrombin. Endothelial cells facilitate the crosstalk between blood coagulation and vascular inflammation. In this study, we compared the effect of RS...

journal_title：Journal of natural medicines

authors： Okamoto T,Akita N,Terasawa M,Hayashi T,Suzuki K

更新日期：2019-06-01 00:00:00

abstract：:It has been found by ribosomal DNA analysis that the endophytic filamentous fungi isolated from the tea plant Camellia sinensis (Theaceae) are composed of six groups; one Fusarium sp., one Penicillium sp., two Schizophyllum sp., and two Diaporthe sp.. ...

journal_title：Journal of natural medicines

authors： Agusta A,Ohashi K,Shibuya H

更新日期：2006-07-01 00:00:00

abstract：:Picrasma javanica Blume (Simaroubaceae) is a medium-sized tree that is distributed widely in tropical Asia. In our previous study, we isolated quassinoids from P. javanica bark collected in Myanmar, and reported their antiproliferative activities. In our ongoing research for the discovery of bioactive compounds from M...

journal_title：Journal of natural medicines

authors： Prema,Wong CP,Nugroho AE,Awouafack MD,Win YY,Win NN,Ngwe H,Morita H,Morita H

更新日期：2019-06-01 00:00:00

abstract：:In vitro screening methods using cultured Neuro2a cells to examine the activation (phosphorylation) of extracellular signal-regulated kinase (ERK) 1/2 and promotion of neurite outgrowth revealed that the extracts of 5 Kampo (Japanese traditional) formulations have potential as medicines for the treatment of behavioral...

journal_title：Journal of natural medicines

authors： Sawamoto A,Okuyama S,Amakura Y,Yamada R,Yoshimura M,Nakajima M,Furukawa Y

更新日期：2018-01-01 00:00:00

abstract：:Phytochemical investigation of the methanol extract of Vitex limonifolia leaves led to the isolation of three new labdane-type diterpenoids, vitexlimolides A-C (1-3) and eight known compounds, 5,4'-dihydroxy-3,7-dimethoxyflavone (4), vitecetin (5), 5,4'-dihydroxy-7,3'-dimethoxyflavone (6), verrucosin (7), 2α, 3α-dihyd...

journal_title：Journal of natural medicines

authors： Ban NK,Thoa NTK,Linh TM,Trang DT,Van Kiem P,Nhiem NX,Tai BH,Van Minh C,Song JH,Ko HJ,Kim SH

更新日期：2018-01-01 00:00:00

abstract：:Two new xanthones namely cratochinone A (1) and cratochinone B (2), along with 16 known xanthones, were isolated from the roots of Cratoxylum cochinchinense. Their structures were characterized by spectroscopic methods, especially 1D and 2D NMR as well as comparison with those reported in the literature for known xant...

journal_title：Journal of natural medicines

authors： Natrsanga P,Jongaramruong J,Rassamee K,Siripong P,Tip-Pyang S

更新日期：2020-03-01 00:00:00

abstract：:Pueraria candollei (P. candollei) is a traditional Thai herb widely used for estrogen replacement therapy because it contains many unique chromenes that possess potent estrogenic activity, one of which is known as isomiroestrol. Since isomiroestrol is a promising compound that is solely present in P. candollei, it can...

journal_title：Journal of natural medicines

authors： Chaingam J,Kitisripanya T,Krittanai S,Sakamoto S,Tanaka H,Putalun W

更新日期：2019-06-01 00:00:00

abstract：:The stem of the Akebia plant, "Mokutsu", is a crude diuretic and antiphlogistic drug. Japanese products prepared from wild Akebia plants cover most of the Mokutsu market. Two Akebia plants, Akebia quinata Decaisne (Aq) and A. trifoliata Koidzumi (At) of Lardizabalaceae, are standardized as Mokutsu in Japanese pharmaco...

journal_title：Journal of natural medicines

authors： Kitaoka F,Kakiuchi N,Long C,Itoga M,Yoshimatsu H,Mitsue A,Atsumi T,Mouri C,Mikage M

更新日期：2009-07-01 00:00:00

abstract：:Two new limonoids, sanjecumins A (1) and B (2), have been isolated from the leaves of Sandoricum koetjape, together with sandoripins A (3) and B (4). Their structures and absolute configurations were elucidated on the basis of NMR and CD data. Sandoripins A (3) and B (4) moderately inhibited nitric oxide production in...

journal_title：Journal of natural medicines

authors： Nagakura Y,Nugroho AE,Hirasawa Y,Hosoya T,Rahman A,Kusumawati I,Zaini NC,Morita H

更新日期：2013-04-01 00:00:00

abstract：:We screened water and methanol extracts of 28 Indonesian medicinal plants for their protein tyrosine phosphatase 1B (PTP1B) inhibitory activities. Nine water extracts, i.e., Alstonia scholaris leaf, Blumea balsamifera, Cinnamomum burmannii, Cymbopogon nardus, Melaleuca leucadendra, Phyllanthus niruri, Piper nigrum, Sy...

journal_title：Journal of natural medicines

authors： Saifudin A,Kadota S,Tezuka Y

更新日期：2013-04-01 00:00:00

abstract：:A novel, efficient, and accurate fingerprinting method using high performance liquid chromatography-photodiode array detection has been developed and optimized for the investigation and demonstration of the variance in chemical properties among Siraitia grosvenorii fruits from different origins. The effects of growth ...

journal_title：Journal of natural medicines

authors： Lu F,Li D,Fu C,Liu J,Huang Y,Chen Y,Wen Y,Nohara T

更新日期：2012-01-01 00:00:00

abstract：:Advanced glycation end-products (AGEs) are associated with a non-enzymatic reaction between the amino group of a protein and the carbonyl group of a sugar during hyperglycemia. The precipitation of AGEs in different tissues leads to many complications, such as endothelial dysfunction, cardiovascular complications, ath...

journal_title：Journal of natural medicines

authors： Abdallah HM,El-Bassossy HM,Mohamed GA,El-Halawany AM,Alshali KZ,Banjar ZM

更新日期：2017-01-01 00:00:00

abstract：:Curcuma comosa is widely used as a traditional herbal medicine for gynecological diseases in South East Asia. Previous studies reported that it has phytoestrogenic activity, and several diarylheptanoids were found to be the active constituents. In this study, the pharmacokinetics profile and organ distribution of thre...

journal_title：Journal of natural medicines

authors： Su J,Sripanidkulchai K,Suksamrarn A,Hu Y,Piyachuturawat P,Sripanidkulchai B

更新日期：2012-07-01 00:00:00

abstract：:The signaling of stem cell factor (SCF) through its receptor Kit is known to play an important role in regulating cutaneous melanogenesis. In the course of UVB-induced pigmentation, the expression of membrane-bound SCF by epidermal keratinocytes is upregulated at an early phase and subsequently activates neighboring m...

journal_title：Journal of natural medicines

authors： Kasamatsu S,Hachiya A,Shimotoyodome Y,Kameyama A,Miyauchi Y,Higuchi K,Fujimori T,Ohuchi A,Shibuya Y,Kitahara T

更新日期：2014-07-01 00:00:00

abstract：:Tetrandrine is a cytotoxic compound capable of exerting remarkable antitumor activity against many cancer cells in vitro and in vivo. However, little is known about its effect on human renal cell carcinoma (RCC). In the present study, using RCC 786-O, 769-P and ACHN cell lines as the model system, we demonstrated the ...

journal_title：Journal of natural medicines

authors： Chen T,Ji B,Chen Y

更新日期：2014-01-01 00:00:00