Abstract：
:Tetrandrine is a cytotoxic compound capable of exerting remarkable antitumor activity against many cancer cells in vitro and in vivo. However, little is known about its effect on human renal cell carcinoma (RCC). In the present study, using RCC 786-O, 769-P and ACHN cell lines as the model system, we demonstrated the anticancer effect of tetrandrine against RCC and clarified its underlying mechanisms. Tetrandrine treatment showed growth inhibitory effects on RCC cells in a time- and dose-dependent manner. Additionally, flow cytometric studies revealed that tetrandrine was capable of inducing G1 cell cycle arrest and apoptosis in RCC cells. Mechanically, activation of caspase-8, caspase-9, and caspase-3 and increasing expression of cell cycle regulatory protein p21(WAF1/CIP1) and p27(KIP1) were observed in tetrandrine-treated RCC cells. This study provides the first evidence that tetrandrine triggered apoptosis and cell cycle arrest in RCC 786-O, 769-P and ACHN cells in vitro; these events are associated with caspase cascade activation and upregulation of p21 and p27. Our results thus provide rational evidence supporting the application of tetrandrine as a novel therapeutic agent against RCC in the clinical setting.
journal_name
J Nat Medjournal_title
Journal of natural medicinesauthors
Chen T,Ji B,Chen Ydoi
10.1007/s11418-013-0765-0subject
Has Abstractpub_date
2014-01-01 00:00:00pages
46-52issue
1eissn
1340-3443issn
1861-0293journal_volume
68pub_type
杂志文章abstract：:Three new compounds, (3S)-dihydrobonducellin 8-O-β-D-glucopyranoside (1), 3',5'-dimethoxy-jezonolid (2), and latisilinoid (3), along with 16 known compounds, were isolated from the twigs of Caesalpinia latisiliqua (Leguminosae). The known compounds were identified as flavonoids, stilbenes, and phenolics as determined ...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-019-01335-2
更新日期：2020-01-01 00:00:00
abstract：:It is generally accepted that fungi have a number of dormant gene clusters for the synthesis of secondary metabolites, and the activation of these gene clusters can expand the diversity of secondary metabolites in culture. Recent studies have revealed that the mycolic acid-containing bacterium Tsukamurella pulmonis ac...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-019-01345-0
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journal_title：Journal of natural medicines
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doi：10.1007/s11418-018-1203-0
更新日期：2018-06-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-015-0929-1
更新日期：2016-01-01 00:00:00
abstract：:Five new coumarins, (+)-peujaponisin (1) and multivittans A-D (2-5), were isolated from the roots of Ligusticum multivittatum Franch., and their structures were established by spectral means. ...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-007-0193-0
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abstract：:The aim of the study was to investigate the in vivo effect of the seashell protein Haishengsu (HSS) on Ehrlich ascites tumor. Mice were inoculated with Ehrlich ascites tumor cells and randomly divided into three HSS groups and a control group. The survival times in the three HSS-treated groups was longer than in the c...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-009-0346-4
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abstract：:Several studies have indicated the involvement of oxidative stress and high glucose-induced cell death in the development of diabetic neuropathy. Satureja khuzestanica has been recommended in the literature as a remedy for the treatment of diabetes, and also contains antioxidant agents. Here, we investigated the possi...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-012-0646-y
更新日期：2013-01-01 00:00:00
abstract：:Taxol is produced by a few microorganisms and plants such as yew (Taxus sp.). Recent researches have shown that hazel (Corylus avellana L.) is also able to produce Taxol. In the present study, effects of different concentrations of phenylalanine (Phe) on the production of Taxol, antioxidant activity, and cytotoxic eff...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-012-0696-1
更新日期：2013-07-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-010-0409-6
更新日期：2010-07-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-016-1051-8
更新日期：2017-01-01 00:00:00
abstract：:Picrasma javanica Blume (Simaroubaceae) is a medium-sized tree that is distributed widely in tropical Asia. In our previous study, we isolated quassinoids from P. javanica bark collected in Myanmar, and reported their antiproliferative activities. In our ongoing research for the discovery of bioactive compounds from M...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-018-01279-z
更新日期：2019-06-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-009-0371-3
更新日期：2010-01-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-013-0770-3
更新日期：2014-01-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-011-0555-5
更新日期：2012-01-01 00:00:00
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journal_title：Journal of natural medicines
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doi：10.1007/s11418-020-01441-6
更新日期：2021-01-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-010-0388-7
更新日期：2010-04-01 00:00:00
abstract：:Antihypertensive treatment is highly important to prevent the progression of chronic kidney disease. Shichimotsukokato (SKT), a traditional Japanese medicine (i.e., Kampo formula), lowered systolic blood pressure (SBP) in experimental animal models of hypertension. However, its mechanism of action has not been fully e...
journal_title：Journal of natural medicines
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doi：10.1007/s11418-015-0945-1
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-010-0432-7
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journal_title：Journal of natural medicines
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journal_title：Journal of natural medicines
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journal_title：Journal of natural medicines
pub_type： 杂志文章
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更新日期：2020-03-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-014-0836-x
更新日期：2014-07-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-008-0261-0
更新日期：2008-10-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-017-1126-1
更新日期：2018-01-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 信件
doi：10.1007/s11418-009-0318-8
更新日期：2009-07-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-012-0704-5
更新日期：2013-07-01 00:00:00
abstract：:From the dried rhizomes of Curcuma comosa cultivating in Thailand, 26 known sesquiterpenes were isolated: zederone, zederone epoxide, furanodienone, isofuranodienone, 1(10)Z,4Z-furanodiene-6-one, glechomanolide, dehydrocurdione, neocurdione, curdione, 7 alpha-hydroxyneocurdione, 7 beta-hydroxycurdione, germacrone-1(10...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-008-0282-8
更新日期：2009-01-01 00:00:00
abstract：:Aloperine (ALO), one of the alkaloids isolated from Sophora alopecuroides L., is traditionally used for various diseases including neuronal disorders. This study investigated the protective effects of ALO on neonatal rat primary-cultured hippocampal neurons injured by oxygen-glucose deprivation and reperfusion (OGD/RP...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-015-0928-2
更新日期：2015-10-01 00:00:00
abstract：:Successive oral administration (50 mg/kg) of a 50% ethanolic extract (HP-ext) of devil's claw, the secondary root of Harpagophytum procumbens, showed a significant anti-inflammatory effect in the rat adjuvant-induced chronic arthritis model. HP-ext dose-dependently suppressed the lipopolysaccharide (LPS)-induced produ...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-010-0395-8
更新日期：2010-04-01 00:00:00
abstract：:Activity-guided isolation of the n-butanol fraction of Chamaerhodos erecta and water soluble fraction of C. altaica resulted in the isolation of 39 compounds, including new compounds identified as 4,5-dihydroxybenzaldehyde-3-O-β-D-glucopyranoside (1) from C. erecta and quercetin-3-O-β-D-glucuronopyranosyl-4'-O-β-D-glu...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-013-0748-1
更新日期：2013-10-01 00:00:00
