当前位置： SCI文献检索 > Journal of Natural Medicines期刊下所有文献 > Adipogenic effects of piperlonguminine in 3T3-L1 cells and plasma concentrations of several amide constituents from Piper chaba extracts after treatment of mice.

Adipogenic effects of piperlonguminine in 3T3-L1 cells and plasma concentrations of several amide constituents from Piper chaba extracts after treatment of mice.

Abstract：

:In our previous study, piperlonguminine from the fruit of Piper chaba was reported to promote adipogenesis in 3T3-L1 cells like the peroxisome proliferator-activated receptor-γ (PPARγ) agonist, troglitazone. In the present study, the mode of action of piperlonguminine in cells was examined. Piperlonguminine increased mRNA levels of adiponectin, glucose transporter 4, and fatty acid-binding protein (aP2). It also increased mRNA levels of PPARγ2 but, unlike troglitazone, piperlonguminine did not activate PPARγ directly in a nuclear receptor cofactor assay. Analyses of plasma from mice treated with piperlonguminine, piperine, and retrofractamide A, and an extract of the fruit, showed that concentrations of piperlonguminine were higher than those of piperine and retrofractamide A, and that the "area-under-the-curve" of piperine increased following in vivo administration of the extract.

journal_name

J Nat Med

journal_title

Journal of natural medicines

authors

Yamaguchi I,Matsuda H,Zhang H,Hamao M,Yamashita C,Kogami Y,Kon'I H,Murata M,Nakamura S,Yoshikawa M

doi

10.1007/s11418-013-0770-3

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

74-82

issue

1

eissn

1340-3443

issn

1861-0293

journal_volume

68

pub_type

杂志文章

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