Abstract：
:Cosmetic industries focus on developing materials and resources that regulate skin pigmentation. Melanin, the major pigment in human skin, protects the skin against damage from ultraviolet light. An ethanolic extract of the leaves of Callicarpa longissima inhibits melanin production in B16F10 mouse melanoma cells by suppressing microphthalmia-associated transcription factor (MITF) gene expression. Following purification and analysis using liquid chromatography-mass spectrometry (LC-MS), NMR, and biochemical assays, carnosol was determined to be responsible for the major inhibitory effect of the C. longissima extract on melanin production. Carnosol is an oxidative product of carnosic acid, whose presence in the extract was also confirmed by an authentic reference. The carnosol and carnosic acid content in the extract was approximately 16% (w/w). These results suggest that C. longissima is a novel, useful, and attractive source of skin-whitening agents.
journal_name
J Nat Medjournal_title
Journal of natural medicinesauthors
Yamahara M,Sugimura K,Kumagai A,Fuchino H,Kuroi A,Kagawa M,Itoh Y,Kawahara H,Nagaoka Y,Iida O,Kawahara N,Takemori H,Watanabe Hdoi
10.1007/s11418-015-0933-5subject
Has Abstractpub_date
2016-01-01 00:00:00pages
28-35issue
1eissn
1340-3443issn
1861-0293pii
10.1007/s11418-015-0933-5journal_volume
70pub_type
杂志文章abstract：:We investigated the cytotoxicity of six neolignans (1-6), which are similar in structure to furanocyclohexenone with an angular allyl group, in human neuroblastoma cell lines (IMR-32, LA-N-1, NB-39, SK-N-SH) and normal cells [human umbilical vein endothelial cells (HUVEC) and human dermal fibroblasts (HDF)] using a 3-...
journal_title：Journal of natural medicines
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journal_title：Journal of natural medicines
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journal_title：Journal of natural medicines
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journal_title：Journal of natural medicines
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journal_title：Journal of natural medicines
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journal_title：Journal of natural medicines
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journal_title：Journal of natural medicines
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更新日期：2016-07-01 00:00:00
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journal_title：Journal of natural medicines
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journal_title：Journal of natural medicines
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更新日期：2013-01-01 00:00:00
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journal_title：Journal of natural medicines
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journal_title：Journal of natural medicines
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更新日期：2018-01-01 00:00:00
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journal_title：Journal of natural medicines
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journal_title：Journal of natural medicines
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journal_title：Journal of natural medicines
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journal_title：Journal of natural medicines
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更新日期：2016-01-01 00:00:00
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journal_title：Journal of natural medicines
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更新日期：2010-04-01 00:00:00
abstract：:Pueraria candollei (P. candollei) is a traditional Thai herb widely used for estrogen replacement therapy because it contains many unique chromenes that possess potent estrogenic activity, one of which is known as isomiroestrol. Since isomiroestrol is a promising compound that is solely present in P. candollei, it can...
journal_title：Journal of natural medicines
pub_type： 杂志文章
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更新日期：2019-06-01 00:00:00
abstract：:Rosae fructus is a traditional Chinese crude drug, used for purgative purposes. It is included in the Japanese Pharmacopoeia XV, in which its origin is stated to be Rosa multiflora Thunberg. These days, some imported Rosae fructus are on the market and the pharmacological activity of the imported product is in questio...
journal_title：Journal of natural medicines
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更新日期：2009-01-01 00:00:00
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journal_title：Journal of natural medicines
pub_type： 杂志文章
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更新日期：2012-04-01 00:00:00
abstract：:(E)-methyl-4-hydroxy-3,5-dimethoxycinnamate, (E)-methyl-4-hydroxy-3-methoxycinnamate, (E)-methyl-4-hydroxycinnamate, (Z)-methyl-4-hydroxycinnamate, calycanthine, ursolic acid, 2-hydroxy-3-methylanthraquinone, 4-methoxybenzoic acid, 3,4,5-trimethoxybenzoic acid, methyl 4-hydroxybenzoate and allantoin were isolated from...
journal_title：Journal of natural medicines
pub_type： 杂志文章
doi：10.1007/s11418-008-0227-2
更新日期：2008-07-01 00:00:00
