New norditerpenoid alkaloids from Aconitum vilmorinianum Komarov.

Abstract:

:Aconitum vilmorinianum Komarov is a local medicinal plant used in many well-known clinical preparations to treat rheumatism and pains in Yunnan Province, China. Phytochemical examination of the roots of A. vilmorinianum led to the isolation of three novel imine-type norditerpenoid alkaloids named vilmorrianines E-G (1-3), and a new natural alkaloid N-desethyl-N-formyl-8-O-methyltalatisamine (4), together with 14 known alkaloids. Their structures were elucidated on the basis of spectroscopic evidence. Vilmorrianine E is the first known norditerpenoid alkaloid containing both an imine group and a three-membered ring formed by C8, C9, and C10.

journal_name

J Nat Med

authors

Chen CL,Tan WH,Wang Y,Xue ZG,Wan CP,Yang ZY,Zhou ZH,Ma XX

doi

10.1007/s11418-015-0926-4

subject

Has Abstract

pub_date

2015-10-01 00:00:00

pages

601-7

issue

4

eissn

1340-3443

issn

1861-0293

journal_volume

69

pub_type

杂志文章
  • Exploration for the real causative agents of licorice-induced pseudoaldosteronism.

    abstract::I investigated the causative agents of licorice-induced pseudoaldosteronism, which is a frequent side effect of Japanese traditional Kampo medicines. Glycyrrhizin (GL), the main ingredient of licorice, is absorbed after being metabolized to glycyrrhetinic acid (GA) by intestinal bacteria, and then metabolized in liver...

    journal_title:Journal of natural medicines

    pub_type: 杂志文章,评审

    doi:10.1007/s11418-021-01484-3

    authors: Makino T

    更新日期:2021-01-22 00:00:00

  • Hirtionosides A-C, gallates of megastigmane glucosides, 3-hydroxyoctanoic acid glucosides and a phenylpropanoid glucoside from the whole plants of Euphorbia hirta.

    abstract::From the 1-BuOH-soluble fraction of a MeOH extract of Euphorbia hirta, collected in the Okinawa islands, three new megastigmane glucoside gallates, named hirtionosides A-C, 3-hydroxyoctanoic acid glucosides and a phenylpropanoid glucoside were isolated along with 15 known compounds. The structures of the new compounds...

    journal_title:Journal of natural medicines

    pub_type: 杂志文章

    doi:10.1007/s11418-012-0692-5

    authors: Nomoto Y,Sugimoto S,Matsunami K,Otsuka H

    更新日期:2013-04-01 00:00:00

  • The protective potential of Yucca schidigera (Sarsaponin 30) against nitrite-induced oxidative stress in rats.

    abstract::The present study was designed to determine the protective effects of Yucca schidigera (Ys) against oxidative damage induced by acute nitrite intoxication as well as the histopathological evaluation of Ys in rats. The rats were divided into three groups each containing 12 rats: control (C); nitrite intoxication (N); Y...

    journal_title:Journal of natural medicines

    pub_type: 杂志文章

    doi:10.1007/s11418-009-0338-4

    authors: Cigerci IH,Fidan AF,Konuk M,Yuksel H,Kucukkurt I,Eryavuz A,Sozbilir NB

    更新日期:2009-07-01 00:00:00

  • The roots of Nardostachys jatamansi inhibits lipopolysaccharide-induced endotoxin shock.

    abstract::Nardostachys jatamansi (NJ) has been used in the treatment of inflammatory diseases. However, it is not clear how NJ produces anti-inflammatory effects. In the present study, using an experimental model of lipopolysaccharide (LPS)-induced endotoxin shock, the protective effects and mechanisms of action of NJ were inve...

    journal_title:Journal of natural medicines

    pub_type: 杂志文章

    doi:10.1007/s11418-010-0458-x

    authors: Bae GS,Seo SW,Kim MS,Park KC,Koo BS,Jung WS,Cho GH,Oh HC,Yun SW,Kim JJ,Kim SG,Hwang SY,Song HJ,Park SJ

    更新日期:2011-01-01 00:00:00

  • Production of monoclonal antibodies against antitumor cyclohexapeptide RA-VII from Rubia cordifolia and their characterization.

    abstract::An immunoassay system was established for the estimation of the quantity of an antitumor cyclic hexapeptide RA-VII (1) from Rubia cordifolia L. and R. akane Nakai (Rubiaceae). First, 1 was converted into its hapten, which was then conjugated with a carrier protein to be used as an effective antigen to obtain its monoc...

    journal_title:Journal of natural medicines

    pub_type: 杂志文章

    doi:10.1007/s11418-011-0508-z

    authors: Hasuda T,Hitotsuyanagi Y,Takeya K

    更新日期:2011-07-01 00:00:00

  • Cytotoxic abietane and kaurane diterpenoids from Celastrus orbiculatus.

    abstract::Celastrus orbiculatus is a medicinal plant belonging to the Celastraceae family. In this survey on the secondary metabolites of plants for obtaining antitumor substances, the chemical constituents of the stems of C. orbiculatus were investigated. Nortriptonoterpene (1), a new C19-norabietane diterpenoid, together with...

    journal_title:Journal of natural medicines

    pub_type: 杂志文章

    doi:10.1007/s11418-019-01326-3

    authors: Jiang W,Shan TZ,Xu JJ,Chen WJ,Miao L,Lv MY,Tao L,Liu YQ

    更新日期:2019-09-01 00:00:00

  • Effects of shakuyakukanzoto and its absorbed components on twitch contractions induced by physiological Ca2+ release in rat skeletal muscle.

    abstract::Shakuyakukanzoto (SKT) is a kampo medicine composed of equal proportions of Glycyrrhizae radix (G. radix) and Paeoniae radix (P. radix). A double-blind study reported that SKT significantly ameliorated painful muscle cramp in cirrhosis patients without the typical severe side effects of muscle weakness and central ner...

    journal_title:Journal of natural medicines

    pub_type: 杂志文章

    doi:10.1007/s11418-015-0890-z

    authors: Kaifuchi N,Omiya Y,Kushida H,Fukutake M,Nishimura H,Kase Y

    更新日期:2015-07-01 00:00:00

  • Pharmacological effect of carvacrol on D: -galactosamine-induced mitochondrial enzymes and DNA damage by single-cell gel electrophoresis.

    abstract::The present study aimed at investigating the effect of carvacrol on hepatic mitochondrial enzyme activities and DNA damage in D: -galactosamine (D: -GalN)-induced hepatotoxicity in male albino Wistar rats. The activities of hepatic mitochondrial enzymes such as isocitrate dehydrogenase, α-ketoglutarate dehydrogenase, ...

    journal_title:Journal of natural medicines

    pub_type: 杂志文章

    doi:10.1007/s11418-011-0544-8

    authors: Aristatile B,Al-Numair KS,Al-Assaf AH,Pugalendi KV

    更新日期:2011-07-01 00:00:00

  • Study on selected trace elements and heavy metals in some popular medicinal plants from Sudan.

    abstract::This study reports on the determination of 11 elements in 33 medicinal plants from Sudan and discusses a possible correlation between their curative effects and their trace elements content. Further, a possible accumulation of adverse heavy metals could be excluded. A total of 11 elements (cadmium, lead, mercury, tin,...

    journal_title:Journal of natural medicines

    pub_type: 信件

    doi:10.1007/s11418-012-0630-6

    authors: Ebrahim AM,Eltayeb MH,Khalid H,Mohamed H,Abdalla W,Grill P,Michalke B

    更新日期:2012-10-01 00:00:00

  • Analysis of CYP3A inhibitory components of star fruit (Averrhoa carambola L.) using liquid chromatography-mass spectrometry.

    abstract::In this study, we analyzed the CYP3A inhibitory components of star fruit Averrhoa carambola L., using liquid chromatography-mass spectrometry (LC-MS). The stereoisomer of procyanidin B1 and B2 and/or the trimer consisting of catechin and/or epicatechin were suggested to be potent inhibitory components. ...

    journal_title:Journal of natural medicines

    pub_type: 杂志文章

    doi:10.1007/s11418-008-0239-y

    authors: Hosoi S,Shimizu E,Arimori K,Okumura M,Hidaka M,Yamada M,Sakushima A

    更新日期:2008-07-01 00:00:00

  • Tetrahydroxanthones from Mongolian medicinal plant Gentianella amarella ssp. acuta.

    abstract::Two tetrahydroxanthones, 1,3,5S,8S-tetrahydroxy-5,6,7,8-tetrahydroxanthone (1) and 1,3,5R,8S-tetrahydroxy-5,6,7,8-tetrahydroxanthone (2), and six new tetrahydroxanthone glycosides, amarellins A-F (3-8), were isolated from the aerial parts of a Mongolian medicinal plant Gentianella amarella ssp. acuta (Gentianaceae). T...

    journal_title:Journal of natural medicines

    pub_type: 杂志文章

    doi:10.1007/s11418-016-1015-z

    authors: Lu S,Tanaka N,Kawazoe K,Murakami K,Damdinjav D,Dorjbal E,Kashiwada Y

    更新日期:2016-10-01 00:00:00

  • Resveratrol oligomer structure in Dipterocarpaceaeous plants.

    abstract::Oligostilbenoids are a group of natural products derived from the oxidative coupling of C6-C2-C6 units found in some plant families. A structurally diverse chemical pool is produced after the successive regioselective and stereoselective oligomerization of resveratrol. This review describes the current status and know...

    journal_title:Journal of natural medicines

    pub_type: 杂志文章,评审

    doi:10.1007/s11418-020-01412-x

    authors: Ito T

    更新日期:2020-09-01 00:00:00

  • C21 steroid derivatives from the Dai herbal medicine Dai-Bai-Jie, the dried roots of Marsdenia tenacissima, and their screening for anti-HIV activity.

    abstract::Twenty-three new C21 steroidal glycosides, marstenacissides C1-C10 (1-10), D1-D7 (11-17) and E1-E6 (18-23), and four new C21 steroids, 11α,12β-O-ditigloyl-tenacigenin C (24), 11α-O-benzoyl-12β-O-tigloyl-tenacigenin C (25), 11α-O-tigloyl-12β-O-benzoyl-tenacigenin C (26) and 11α-O-tigloyl-12β-O-benzoyl-marsdenin (27), w...

    journal_title:Journal of natural medicines

    pub_type: 杂志文章

    doi:10.1007/s11418-017-1126-1

    authors: Pang X,Kang LP,Fang XM,Yu HS,Han LF,Zhao Y,Zhang LX,Yu LY,Ma BP

    更新日期:2018-01-01 00:00:00

  • Red ginseng and 20(S)-Rg3 control testosterone-induced prostate hyperplasia by deregulating androgen receptor signaling.

    abstract::Since prostate growth is governed by the androgen signaling pathway, blockade of the pathway is regarded as an appropriate strategy for the treatment of benign prostatic hyperplasia (BPH). Panax ginseng is known to have various pharmacological activities. Of several products of its root, red ginseng, having many bioac...

    journal_title:Journal of natural medicines

    pub_type: 杂志文章

    doi:10.1007/s11418-011-0609-8

    authors: Bae JS,Park HS,Park JW,Li SH,Chun YS

    更新日期:2012-07-01 00:00:00

  • Aqueous-methanolic extract of sweet flag (Acorus calamus) possesses cardiac depressant and endothelial-derived hyperpolarizing factor-mediated coronary vasodilator effects.

    abstract::This investigation was aimed to probe the pharmacological base of medicinal use of Acorus calamus in ischemic heart diseases. Effect on heart parameters was studied in isolated rabbit heart while coronary vasodilator effect was studied in isolated bovine coronary arterial rings, suspended in tissue baths filled with K...

    journal_title:Journal of natural medicines

    pub_type: 杂志文章

    doi:10.1007/s11418-011-0561-7

    authors: Shah AJ,Gilani AH

    更新日期:2012-01-01 00:00:00

  • Effects of Acanthopanax senticosus HARMS extract on drug transport in human intestinal cell line Caco-2.

    abstract::Acanthopanax senticosus HARMS (AS) is used as a Chinese herbal medicine and as a health supplement in Japan. However, little is known about the interaction between AS and other drugs. In this study, we investigated the effect of AS extract on intestinal drug transporter (P-glycoprotein, or P-gp) and peptide transporte...

    journal_title:Journal of natural medicines

    pub_type: 杂志文章

    doi:10.1007/s11418-009-0371-3

    authors: Takahashi T,Kaku T,Sato T,Watanabe K,Sato J

    更新日期:2010-01-01 00:00:00

  • Ferrearin C induces apoptosis via heme oxygenase-1 (HO-1) induction in neuroblastoma.

    abstract::We investigated the cytotoxicity of six neolignans (1-6), which are similar in structure to furanocyclohexenone with an angular allyl group, in human neuroblastoma cell lines (IMR-32, LA-N-1, NB-39, SK-N-SH) and normal cells [human umbilical vein endothelial cells (HUVEC) and human dermal fibroblasts (HDF)] using a 3-...

    journal_title:Journal of natural medicines

    pub_type: 杂志文章

    doi:10.1007/s11418-011-0514-1

    authors: Hayama T,Tabata K,Uchiyama T,Fujimoto Y,Suzuki T

    更新日期:2011-07-01 00:00:00

  • Selective cytotoxicity of epidithiodiketopiperazine DC1149B, produced by marine-derived Trichoderma lixii on the cancer cells adapted to glucose starvation.

    abstract::The core of solid tumors is characterized by hypoxia and a nutrient-starved microenvironment and has gained much attention as targets of anti-cancer drugs. In the course of search for selective growth inhibitors against the cancer cells adapted to nutrient starvation, epidithiodiketopiperazine DC1149B (1) together wit...

    journal_title:Journal of natural medicines

    pub_type: 杂志文章

    doi:10.1007/s11418-019-01357-w

    authors: Tang R,Kimishima A,Ishida R,Setiawan A,Arai M

    更新日期:2020-01-01 00:00:00

  • Evodiamine ameliorates liver fibrosis in rats via TGF-β1/Smad signaling pathway.

    abstract::Liver fibrosis is considered to be a result of chronic liver pathological changes, and hepatic stellate cells (HSCs) play an important role during this process. Evodiamine, an indole alkaloid derived from Evodia rutaecarpa, exhibits pharmacological activities. This study focused on the effects of evodiamine on carbon ...

    journal_title:Journal of natural medicines

    pub_type: 杂志文章

    doi:10.1007/s11418-017-1122-5

    authors: Yang D,Li L,Qian S,Liu L

    更新日期:2018-01-01 00:00:00

  • Protective effect of Mimosa pudica L. in an L-arginine model of acute necrotising pancreatitis in rats.

    abstract::Mimosa pudica is used in traditional medicine for treating various disorders such as inflammatory conditions, diarrhoea, insomnia, alopecia, urogenital infections and wounds. The present study investigated the effect of M. pudica extract (MPE) on L-arginine-induced acute necrotising pancreatitis in rats. The ethanolic...

    journal_title:Journal of natural medicines

    pub_type: 杂志文章

    doi:10.1007/s11418-016-0991-3

    authors: Kaur J,Sidhu S,Chopra K,Khan MU

    更新日期:2016-07-01 00:00:00

  • Furostanol glycosides from the rhizomes of Helleborus orientalis.

    abstract::Eight new furostanol glycosides (1-8), together with two known ones (9 and 10), have been isolated from a glycoside-enriched fraction prepared from the rhizomes of Helleborus orientalis (Ranunculaceae). The structures of 1-8 were determined on the basis of extensive spectroscopic analysis, including 2D NMR, and the re...

    journal_title:Journal of natural medicines

    pub_type: 杂志文章

    doi:10.1007/s11418-010-0432-7

    authors: Mimaki Y,Matsuo Y,Watanabe K,Sakagami H

    更新日期:2010-10-01 00:00:00

  • Bastadins, cyclic tetramers of brominated-tyrosine derivatives, selectively inhibit the proliferation of endothelial cells.

    abstract::Eight bastadins, tetramers of brominated-tyrosine derivatives, were isolated from the marine sponge Ianthella basta, and their anti-proliferative activities against endothelial cells were examined. A structure-activity relationship study of these compounds revealed that a macrocyclic structure was crucial, and a basta...

    journal_title:Journal of natural medicines

    pub_type: 杂志文章

    doi:10.1007/s11418-006-0045-3

    authors: Aoki S,Cho SH,Hiramatsu A,Kotoku N,Kobayashi M

    更新日期:2006-07-01 00:00:00

  • Antiplasmodial indole alkaloids from Leuconotis griffithii.

    abstract::A new indole alkaloid, leucoridine A N-oxide (1), consisting of two units of a strychnan type of skeleton, was isolated from the leaves of Leuconotis griffithii. Its structure was elucidated by various spectroscopic means such as NMR and MS, and also by chemical means. Antiplasmodial activity against Plasmodium falcip...

    journal_title:Journal of natural medicines

    pub_type: 杂志文章

    doi:10.1007/s11418-011-0574-2

    authors: Nugroho AE,Hirasawa Y,Piow WC,Kaneda T,Hadi AH,Shirota O,Ekasari W,Widyawaruyanti A,Morita H

    更新日期:2012-04-01 00:00:00

  • Methylquercetins stimulate melanin biosynthesis in a three-dimensional skin model.

    abstract::In a previous study, we found that both synthetic 3-O-methylquercetin (3MQ) and 3,4',7-O-trimethylquercetin (34'7TMQ) increased extracellular melanin content. 34'7TMQ increased the activity of melanogenic enzymes by stimulating the p38 pathway and the expression of microphthalmia-associated transcription factor (MITF)...

    journal_title:Journal of natural medicines

    pub_type: 杂志文章

    doi:10.1007/s11418-018-1175-0

    authors: Yamauchi K,Mitsunaga T

    更新日期:2018-03-01 00:00:00

  • Establishment of a methodology for identifying Paeoniae Radix based on metallomic analysis.

    abstract::We aimed to establish a methodology for identifying Paeonia samples based on metallomic analysis. We prepared 66 batches of samples (16 batches of crude drugs and 50 batches of cultivars, comprising 64 batches of Paeonia lactiflora and 2 batches of P. veitchii) collected from Japan and China (Inner Mongolia and elsewh...

    journal_title:Journal of natural medicines

    pub_type: 杂志文章

    doi:10.1007/s11418-013-0795-7

    authors: Shimada K,Nakamura Y,Kawase M,Komatsu K,Saito T,Takahashi K

    更新日期:2014-04-01 00:00:00

  • Adipogenic effects of piperlonguminine in 3T3-L1 cells and plasma concentrations of several amide constituents from Piper chaba extracts after treatment of mice.

    abstract::In our previous study, piperlonguminine from the fruit of Piper chaba was reported to promote adipogenesis in 3T3-L1 cells like the peroxisome proliferator-activated receptor-γ (PPARγ) agonist, troglitazone. In the present study, the mode of action of piperlonguminine in cells was examined. Piperlonguminine increased ...

    journal_title:Journal of natural medicines

    pub_type: 杂志文章

    doi:10.1007/s11418-013-0770-3

    authors: Yamaguchi I,Matsuda H,Zhang H,Hamao M,Yamashita C,Kogami Y,Kon'I H,Murata M,Nakamura S,Yoshikawa M

    更新日期:2014-01-01 00:00:00

  • Attenuating effect of Fufang Xueshuantong Capsule on kidney function in diabetic nephropathy model.

    abstract::Fufang Xueshuantong Capsule (FXST) can reduce urinary albumin and whole blood viscosity in early diabetic nephropathy (DN) patients. This research aimed to investigate the effect of FXST on kidney function in DN rats and to identify the underlying molecular mechanisms. We performed Illumina RatRef-12 Expression BeadCh...

    journal_title:Journal of natural medicines

    pub_type: 杂志文章

    doi:10.1007/s11418-012-0654-y

    authors: Zhang Q,Xiao X,Li M,Li W,Yu M,Zhang H,Sun X,Mao L,Xiang H

    更新日期:2013-01-01 00:00:00

  • A new diterpenoid from the leaves of Clerodendron trichotomum.

    abstract::A new diterpenoid was isolated from the leaves of Clerodendron trichotomumThunb. (Verbenaceae) along with one each of a known diterpenoid, phenylethanoid glycoside, and sterol and two known flavonoids. Their chemical structures were characterized on the basis of spectroscopic data and X-ray analysis. In addition, thei...

    journal_title:Journal of natural medicines

    pub_type: 杂志文章

    doi:10.1007/s11418-012-0690-7

    authors: Ono M,Furusawa C,Matsumura K,Noguchi S,Yasuda S,Okawa M,Kinjo J,Eto M,Yamaguchi K,Yoshimitsu H,Nohara T

    更新日期:2013-04-01 00:00:00

  • Tetrandrine triggers apoptosis and cell cycle arrest in human renal cell carcinoma cells.

    abstract::Tetrandrine is a cytotoxic compound capable of exerting remarkable antitumor activity against many cancer cells in vitro and in vivo. However, little is known about its effect on human renal cell carcinoma (RCC). In the present study, using RCC 786-O, 769-P and ACHN cell lines as the model system, we demonstrated the ...

    journal_title:Journal of natural medicines

    pub_type: 杂志文章

    doi:10.1007/s11418-013-0765-0

    authors: Chen T,Ji B,Chen Y

    更新日期:2014-01-01 00:00:00

  • New phenolic compounds from Camellia sinensis L. fermented leaves.

    abstract::Two new phenolic compounds (1 and 2, named as teasperol and teasperin, respectively) were isolated from fermented tea (Camellia sinensis L.) products, together with known phenolic compounds. Teasperol (1) was isolated from Chinese traditional post-fermented tea leaves (Liu-pao tea) and teasperin (2) was from a Japanes...

    journal_title:Journal of natural medicines

    pub_type: 杂志文章

    doi:10.1007/s11418-012-0704-5

    authors: Kanegae A,Sakamoto A,Nakayama H,Nakazono Y,Yakashiro I,Matsuo Y,Tanaka T,Ishimaru K

    更新日期:2013-07-01 00:00:00